Titanium alloys for fracture fixation implants

Disegi, John A.

doi:10.1016/s0020-1383(00)80017-0

Cited by 116 publications

(59 citation statements)

References 3 publications

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“…In a previous study in which the implants including titanium were also implanted subcutaneously, a biphasic release of TNF-a was demonstrated over time. 40 The major focus of interest for applications with titanium has been calcified tissue, with which titanium integrates well, [41][42][43][44] rendering it a most widely used implant material in dental and other musculoskeletal clinical applications, for example. Attempts have been made to alter the topographical properties to optimize the host response.…”

Section: Discussionmentioning

confidence: 99%

Early inflammatory response in soft tissues induced by thin calcium phosphates

Rydén

Molnár

Esposito

et al. 2013

J Biomedical Materials Res

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The inflammatory response to titanium and hydroxyapatite (HA)-coated titanium in living tissue is controlled by a number of humoral factors, of which monocyte chemoattractant protein-1 (MCP-1) has been specifically linked to the recruitment of monocytes. These cells subsequently mature into tissue-bound macrophages. Macrophages adhering to the proteins adsorbed at the implant surface play a pivotal role in initiating the rejection or integration of the foreign material. Despite this, little is known about the initial inflammatory events that occur in soft tissues following the implantation of titanium and HA-coated titanium implants. In this study, circular discs of commercially pure titanium (c.p. Ti) with either a thin crystalline HA coating or amorphous HA coating or uncoated were implanted subcutaneously into rats. The implants were retrieved after 24 and 72 h. The lactate dehydrogenase (LD) activity, DNA content, expression of MCP-1, interleukin-10 (IL-10), tumor necrosis factor α (TNF-α), as well as monocyte and polymorphonuclear granulocyte counts in the exudate surrounding the implants were analyzed. There were significantly higher DNA and LD levels around the titanium implants at 24 h compared with HA-coated titanium. A rapid decrease in MCP-1 levels was observed for all the implants over the period of observation. No statistically significant differences were found between the two HA-coated implants. Our results suggest a difference in the early soft-tissue response to HA-coated implants when compared with titanium implants, expressed as a downregulation of inflammatory cell recruitment. This suggests that thin HA coatings are promising surfaces for soft tissue applications.

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Section: Discussionmentioning

confidence: 99%

Early inflammatory response in soft tissues induced by thin calcium phosphates

Rydén

Molnár

Esposito

et al. 2013

J Biomedical Materials Res

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“…Recent biomaterials research has been focused on β titanium alloys because processing variables can be controlled to produce selected results. Enhanced properties such as lower modulus of elasticity, increased corrosion resistance, better ductility, and improved notch sensitivity resistance are possible when compared to α + β titanium alloys 3 . Alloys containing elements such as Nb, Zr, Ta, Pt and Ti are being extensively evaluated since these are the only five elements that have been identified as producing no adverse tissue reaction 4 .…”

Section: Introductionmentioning

confidence: 99%

Study of the non-linear stress-strain behavior in Ti-Nb-Zr alloys

Schneider¹,

Silva

Neto

2005

Mat. Res.

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The aim of this work is to study the elastic behavior of some Ti-Nb-Zr alloys ) developed to biomedical applications. These alloys were produced by arc melting under argon atmosphere. Uniaxial tensile tests, carried out in a MST servo-hydraulic machine, were employed in their mechanical characterization. The occurrence of non-linear stress-strain behavior in the conventional elastic region (total strain values up to 0.2%) lead to the Ramberg-Osgood relationship, modified by Hill, in order to analyze that portion of the obtained curves. The present study involves the following properties: initial elastic modulus, tangent modulus, secant modulus, proof stress and the Ramberg-Osgood parameter (n). The results demonstrate that these alloys are not similar with respect to the mechanical behavior. Furthermore, it is shown that the degree of non-linearity in the stress-strain behavior is quantified by the parameter (n).

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“…17 Despite satisfactory clinical experience with these metals, the use of Ti-6Al-4V remains controversial. 1,18,19 Although to date no prospective clinical trial has demonstrated the higher inflammatory potential of Ti alloys compared to cpTi, considerable in vitro laboratory data supports the hypothesis that Ti-6Al-4V and its constituents are capable of causing biological harm.…”

Section: Discussionmentioning

confidence: 99%

Short‐term microvascular response of striated muscle to cp‐Ti, Ti‐6Al‐4V, and Ti‐6Al‐7Nb

Pennekamp

Geßmann

Diedrich

et al. 2006

Journal Orthopaedic Research

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Due to excellent mechanical properties and good corrosion resistance, titaniumaluminium-vanadium (Ti-6Al-4V) and titanium-aluminium-niobium (Ti-6Al-7Nb) are extensively used for orthopedic surgery. Concern has been voiced concerning the implications of the constituent vanadium in Ti-6Al-4V on the surrounding environment. Particularly in osteosynthesis where the alloys stand in direct contact to skeletal muscle, undesirable biologic reactions may have severe consequences. In a comparative study, we assessed in vivo nutritive perfusion and leukocytic response of striated muscle to the metals Ti-6Al-4V, Ti-6Al-7Nb, and commercially pure titanium (cp-Ti), thereby drawing conclusions on their short-term inflammatory potential. In 28 hamsters, utilizing the dorsal skinfold chamber preparation and intravital microscopy, we quantified primary and secondary leukocyte-endothelial cell interaction, leukocyte extravasation, microvascular diameter change, and capillary perfusion in collecting and postcapillary venules of skeletal muscle. A manifest discrepancy between the metals concerning impact on local microvascular parameters was not found. All metals induced an only transient and moderate inflammatory response. Only a slight increase in leukocyte recruitment and a more sluggish recuperation of inflammatory parameters in animals treated with Ti-6Al-4V compared to the other two metals suggested a minor, overall not significant discrepancy in biocompatibility. Gross toxicity of bulk Ti-6Al-4V on surrounding tissue could not be found. Conclusively, the commonly used biomaterials Ti-6Al-4V, Ti-6Al-7Nb, and cp-Ti induce an only transient inflammatory answer of the skeletal muscle microvascular system. Our results indicate that on the microvascular level the tested bulk Ti-alloys and cpTi do not cause adverse biologic reactions in striated muscle. ß

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Titanium alloys for fracture fixation implants

Cited by 116 publications

References 3 publications

Early inflammatory response in soft tissues induced by thin calcium phosphates

Early inflammatory response in soft tissues induced by thin calcium phosphates

Study of the non-linear stress-strain behavior in Ti-Nb-Zr alloys

Short‐term microvascular response of striated muscle to cp‐Ti, Ti‐6Al‐4V, and Ti‐6Al‐7Nb

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