Titanium alloy cannulated screws and biodegrade ceramic nails for treatment of femoral neck fractures: A finite element analysis

Liu, Yang; Ren, Zhiyuan; Shao, Huifeng; Wang, Xueding; Ma, Yongsheng; Song, Wenjie; Wu, Xiaogang; Zhang, Xiangyu; Li, Pengcui; He, Yong; Wei, Xiaochun; Duan, Wei

doi:10.1016/j.injury.2023.110841

Cited by 4 publications

(1 citation statement)

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“…The metabolomics of this study findings indicate that glycerophospholipid and choline metabolism are the most significantly enriched pathways in comparisons between the sclerosis and fracture groups, as well as the necrosis and fracture groups, highlighting their essential roles in bone metabolism and femoral head osteonecrosis. This provides evidence for a potential link between sclerosis around screw paths and FHN, aligning with our prior research 51 . Nevertheless, additional studies are essential to decode the exact mechanisms through which these metabolic pathways impact bone metabolism and femoral head osteonecrosis and to identify viable therapeutic targets.…”

Section: Discussionsupporting

confidence: 89%

Integrated proteomics and metabolomics analysis of sclerosis-related proteins and femoral head necrosis following internal fixation of femoral neck fractures

Liu,

Ma,

Yang

et al. 2024

Sci Rep

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Femoral head necrosis (FHN) is a serious complication after femoral neck fractures (FNF), often linked to sclerosis around screw paths. Our study aimed to uncover the proteomic and metabolomic underpinnings of FHN and sclerosis using integrated proteomics and metabolomics analyses. We identified differentially expressed proteins (DEPs) and metabolites (DEMs) among three groups: patients with FNF (Group A), sclerosis (Group B), and FHN (Group C). Using the Kyoto Encyclopedia of Genes and Genomes and Gene Ontology enrichment analyses, we examined the roles of these proteins and metabolites. Our findings highlight the significant differences across the groups, with 218 DEPs and 44 DEMs identified between the sclerosis and FNF groups, 247 DEPs and 31 DEMs between the FHN and sclerosis groups, and a stark 682 DEPs and 94 DEMs between the FHN and FNF groups. Activities related to carbonate dehydratase and hydrolase were similar in the FHN and sclerosis groups, whereas extracellular region and lysosome were prevalent in the FHN and FNF groups. Our study also emphasized the involvement of the PI3K-Akt pathway in sclerosis and FHN. Moreover, the key metabolic pathways were implicated in glycerophospholipid metabolism and retrograde endocannabinoid signaling. Using western blotting, we confirmed the pivotal role of specific genes/proteins such as ITGB5, TNXB, CA II, and CA III in sclerosis and acid phosphatase 5 and cathepsin K in FHN. This comprehensive analyses elucidates the molecular mechanisms behind sclerosis and FHN and suggests potential biomarkers and therapeutic targets, paving the way for improved treatment strategies. Further validation of the findings is necessary to strengthen the robustness and reliability of the results.

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Section: Discussionsupporting

confidence: 89%