Titania nanostructures: a biomedical perspective

Damodaran, Vinod B.; Bhatnagar, Divya; Leszczak, Victoria; Popat, Ketul C.

doi:10.1039/c5ra04271b

Cited by 55 publications

(37 citation statements)

References 212 publications

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“…The FBR is known to be affected by surface properties such as implant topography and chemistry. Here, the interaction between defense cells and especially structures in the nanoregime has gained increasing interest [5][6][7]. The generation of a surface comprising nanofeatures is, in this case, particularly interesting for an extensively used biomaterial like titanium, as can be derived from the variety of manufacturing methods that are applied for this purpose [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Nanotopographical Coatings Induce an Early Phenotype-Specific Response of Primary Material-Resident M1 and M2 Macrophages

et al. 2020

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Implants elicit an immunological response after implantation that results in the worst case in a complete implant rejection. This biomaterial-induced inflammation is modulated by macrophages and can be influenced by nanotopographical surface structures such as titania nanotubes or fractal titanium nitride (TiN) surfaces. However, their specific impact on a distinct macrophage phenotype has not been identified. By using two different levels of nanostructures and smooth samples as controls, the influence of tubular TiO2 and fractal TiN nanostructures on primary human macrophages with M1 or M2-phenotype was investigated. Therefore, nanotopographical coatings were either, directly generated by physical vapor deposition (PVD) or by electrochemical anodization of titanium PVD coatings. The cellular response of macrophages was quantitatively assessed to demonstrate a difference in biocompatibility of nanotubes in respect to human M1 and M2-macrophages. Depending on the tube diameter of the nanotubular surfaces, low cell numbers and impaired cellular activity, was detected for M2-macrophages, whereas the impact of nanotubes on M1-polarized macrophages was negligible. Importantly, we could confirm this phenotypic response on the fractal TiN surfaces. The results indicate that the investigated topographies specifically impact the macrophage M2-subtype that modulates the formation of the fibrotic capsule and the long-term response to an implant.

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Section: Introductionmentioning

confidence: 99%

Nanotopographical Coatings Induce an Early Phenotype-Specific Response of Primary Material-Resident M1 and M2 Macrophages

et al. 2020

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“…Titanium has been shown to be biocompatible but blood clots readily form on titanium devices, leading to their failure. 27 Superhemophobic surfaces were fabricated by rst modifying the topography and then the chemistry of titanium surfaces. The surface topography was modied by fabricating titania nanotube arrays on titanium surface.…”

Section: Introductionmentioning

confidence: 99%

Superhemophobic titania nanotube array surfaces for blood contacting medical devices

et al. 2017

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“…Titania is an important class of materials that are widely used in many different fields including photocatalysis [35] and biomedical treatment. [36] In addition, immobilization of differente nzymes on titaniumoxide supports has been achieved in variousw ays, and such nanocomposites weret ested in enzymatic assays. [20,23,[37][38][39] For instance, SOD was attached to titania-modifiede lectrodes by physicala dsorption to develop biosensors for detection of the superoxide radical anion.…”

Section: Introductionmentioning

confidence: 99%

Immobilization of Superoxide Dismutase on Polyelectrolyte‐Functionalized Titania Nanosheets

2017

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The superoxide dismutase (SOD) enzyme was successfully immobilized on titania nanosheets (TNS) functionalized with the poly(diallyldimethylammonium chloride) (PDADMAC) polyelectrolyte. The TNS-PDADMAC solid support was prepared by hydrothermal synthesis followed by self-assembled polyelectrolyte layer formation. It was found that SOD strongly adsorbed onto oppositely charged TNS-PDADMAC through electrostatic and hydrophobic interactions. The TNS-PDADMAC-SOD material was characterized by light scattering and microscopy techniques. Colloidal stability studies revealed that the obtained nanocomposites possessed good resistance against salt-induced aggregation in aqueous suspensions. The enzyme kept its functional integrity upon immobilization; therefore, TNS-PDADMAC-SOD showed excellent superoxide radical anion scavenging activity. The developed system is a promising candidate for applications in which suspensions of antioxidant activity are required in the manufacturing processes.

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Titania nanostructures: a biomedical perspective

Abstract: A systematic and comprehensive summary of various TNS-based biomedical research with a special emphasis on drug-delivery, tissue engineering, biosensor, and anti-bacterial applications.

Cited by 55 publications

References 212 publications

Nanotopographical Coatings Induce an Early Phenotype-Specific Response of Primary Material-Resident M1 and M2 Macrophages

Nanotopographical Coatings Induce an Early Phenotype-Specific Response of Primary Material-Resident M1 and M2 Macrophages

Superhemophobic titania nanotube array surfaces for blood contacting medical devices

Immobilization of Superoxide Dismutase on Polyelectrolyte‐Functionalized Titania Nanosheets

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