2015
DOI: 10.23937/2378-3664/1410009
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Titanates and Titanate-Metal Compounds in Biological Contexts

Abstract: Metal ions are notorious environmental contaminants, some causing toxicity at exquisitely low (ppm-level) concentrations. Yet, the redox properties of metal ions make them attractive candidates for bio-therapeutics. Titanates are insoluble particulate compounds of titanium and oxygen with crystalline surfaces that bind metal ions; these compounds offer a means to scavenge metal ions in environmental contexts or deliver them in therapeutic contexts while limiting systemic exposure and toxicity. In either applic… Show more

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Cited by 3 publications
(4 citation statements)
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“…The use of metal ions as medicinal drugs is made possible by their unique and wide variety of redox potentials, geometries, thermodynamic and kinetic properties, and other intrinsic properties as therapeutic agents [1]. Metal ions have been used in medicinal contexts in the treatment of cancers, inflammation, and arthritis, among others [2]. Metal ions have also long been known to contain chemical properties that cause them to successfully inhibit bacterial growth.…”
Section: Introductionmentioning
confidence: 99%
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“…The use of metal ions as medicinal drugs is made possible by their unique and wide variety of redox potentials, geometries, thermodynamic and kinetic properties, and other intrinsic properties as therapeutic agents [1]. Metal ions have been used in medicinal contexts in the treatment of cancers, inflammation, and arthritis, among others [2]. Metal ions have also long been known to contain chemical properties that cause them to successfully inhibit bacterial growth.…”
Section: Introductionmentioning
confidence: 99%
“…Given the growing resistance of microbes to current antimicrobial agents, the need for a new class of antimicrobials has become increasingly apparent, and metal ions may serve as a new treatment modality in this context. Concerns over the potential systemic toxicity of metals to the host have halted their widespread use as therapeutic agents, but if the use of metal ions is localized and controlled, their toxicity to the host could be greatly minimized [2]. This creates a unique niche for the novel approach of using metal-titanate complexes to fight pathogen-causing microbes due to the ability of such complexes to deliver metal ions in a controlled manner.…”
Section: Introductionmentioning
confidence: 99%
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