Tissuegene-C (TG-C) In patients with osteoarthritis: a phase IIb clinical study

Abstract

to treatment (p¼0.001); effect size 0.76. There was a statistically significant increase in HOOS of 12.4 at 52 weeks (p<0.0005); effect size 0.76 when comparing the treatment and control groups. The UCLA activity score showed an increase of 0.66 (p¼0.019); effect size 0.43 in favour of the treatment group at 52 weeks. The EQ5D summary index increased by 0.85 (p¼0.005); effect size 0.76 at 52 weeks when moving from the control group to the treatment group. Hip flexion (increase of 17.9, p<0.0005) and hip extension (increase of 5.7, p¼.004) also showed a marked improvement between the treatment group and the control group. Muscle strength improved more in the intervention group but was not statistically significant. Eighty percent (32 of 40) of the intervention group fully met their self-selected goal compared to 55% (22 of 40) of the control group. Conclusions: A simple tailored exercise programme resulted in marked increases in hip range of motion and self reported function than the previous conventional rehabilitation programme. A change in the emphasis of post-operative rehabilitation could improve outcome for patients after hip resurfacing arthroplasty