Tissue tropism of a Thailand strain of high-pathogenicity avian influenza virus (H5N1) in tissues of naturally infected native chickens (Gallus gallus), Japanese quail (Coturnix coturnix japonica) and ducks (Anasspp.)

Antarasena, Chongmas; Sirimujalin, Rungtiva; Prommuang, Porntip; Blacksell, Stuart D.; Promkuntod, N.; Prommuang, Praison

doi:10.1080/03079450600714510

Cited by 38 publications

(39 citation statements)

References 11 publications

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“…The nasal cavity, brain, heart, and spleen had histologic lesions and immunostaining similar to those previously reported for HPAIV infection in chickens 1,6,7 and were consistent with systemic viral infection.…”

supporting

confidence: 83%

“…In quail, 78% of the oviduct samples were positive for virus staining, but no details were given as to the cell types infected and which section of the reproductive tract was affected. 1 All hens analyzed in this study after 36 hours PI for groups 2 and 3 and after 48 hours PI for group 1 presented variable levels of positive virus staining in several portions of the oviduct.…”

mentioning

confidence: 76%

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High-Pathogenicity Avian Influenza Virus in the Reproductive Tract of Chickens

et al. 2013

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Infection with high-pathogenicity avian influenza virus (HPAIV) has been associated with a wide range of clinical manifestations in poultry, including severe depression in egg production and isolation of HPAIV from eggs laid by infected hens. To evaluate the pathobiology in the reproductive tract of chickens, adult hens were inoculated intranasally with 3 HPAIV strains. All 3 strains induced lesions in the reproductive tract 36 to 72 hours after inoculation. Positive immunostaining was observed in all segments of the reproductive tract, occurring predominantly in stromal cells and superficial germinal epithelium of the ovary, in mucosal epithelial cells and less often glandular epithelium throughout the oviduct, and in vascular endothelium. This study generates important data and explains previously reported virus isolation from yolk, due to ovarian virus replication, and virus recovery from albumin, due to virus replication in epithelial cells in several segments of the oviduct.

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supporting

confidence: 83%

mentioning

confidence: 76%

High-Pathogenicity Avian Influenza Virus in the Reproductive Tract of Chickens

et al. 2013

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“…Although HPAIV have been detected in infected chicken, duck, and quail meat to a very high titer (2,38,39), no evidence for the presence of LPAIV in the meat of infected birds is available (30). On the other hand, LPAIV from respiratory secretions or feces can be a source of carcass surface contamination during the slaughtering process (39).…”

Section: Discussionmentioning

confidence: 99%

Persistence of Avian Influenza Viruses in Lake Sediment, Duck Feces, and Duck Meat

Nazir

Haumacher

Ike

et al. 2011

Appl Environ Microbiol

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The persistence of 3 low-pathogenicity avian influenza viruses (LPAIV) (H4N6, H5N1, and H6N8) and one human influenza virus (H1N1) as well as Newcastle disease virus (NDV) and enteric cytopathogenic bovine orphan (ECBO) virus was investigated in lake sediment, duck feces, and duck meat at 30, 20, 10, and 0°C using a germ carrier technique. Virus-loaded germ carriers were incubated in each substrate, and residual infectivity of the eluted virus was quantified on cell culture after regular intervals for a maximum of 24 weeks. Data were analyzed by a linear regression model to calculate T 90 values (time required for 90% loss of virus infectivity) and estimated persistence of the viruses. In general, the persistence of all of the viruses was highest in lake sediment, followed by feces, and was the lowest in duck meat at all temperatures. For the avian influenza virus subtypes, T 90 values in sediment ranged from 5 to 11, 13 to 18, 43 to 54, and 66 to 394 days at 30, 20, 10, and 0°C, respectively, which were 2 to 5 times higher than the T 90 values of the viruses in the feces and meat. Although the individual viruses vary in tenacity, the survival time of influenza viruses was shorter than that of NDV and ECBO virus in all substrates. The results of this study suggest that lake sediment may act as a long-term source of influenza viruses in the aquatic habitat, while the viruses may remain infectious for extended periods of time in duck feces and meat at low temperatures, allowing persistence of the viruses in the environment over winter.

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“…Such information may form a basis for control measures during AIV outbreaks and/or limit AIV circulation, which is a risk factor in the generation of new reassortant viruses with other AIV strains from other animals such as swine or even humans. Infectious AIV has already been found in different tissues of infected chickens (Serena Beato et al, 2006;Starick & Werner, 2003;Swayne, 2007), ducks (Tumpey et al, 2002), turkeys , swans and geese (Brown et al, 2008), and detected in the muscles of infected chickens (Swayne & Beck, 2005), turkeys (Toffan et al, 2008), ducks and quails (Antarasena et al, 2006). HPAIV has also been detected in commercial frozen duck carcasses of retained slaughter batches (Harder et al, 2009), which has increased concern about the food safety of poultry products by its zoonotic implications.…”

Section: Introductionmentioning

confidence: 99%