Tissue Transglutaminase Can Be Involved in Airway Inflammation of Toluene Diisocyanate-Induced Occupational Asthma

Hur, Gyu Young; Kim, Sung Hoon; Park, Sang Myun; Ye, Young-Min; Kim, Cheol Woo; Jang, An Soo; Park, Choon-Sik; Hong, Chein Soo; Park, Hae‐Sim

doi:10.1007/s10875-009-9314-8

Cited by 27 publications

(21 citation statements)

References 41 publications

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“…A previous report demonstrated that TDI exposure induces ROS generation [19]. We also observed that human serum albumin-conjugated TDI induced ROS generation in A549 cells [20]. Furthermore, in our recent previous report, we found that decreased ferritin expression in association with increased transferrin was noted in the bronchoalveolar lavage fluid and serum of patients with MDI-OA [11].…”

Section: Discussionsupporting

confidence: 64%

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Toluene diisocyanate (TDI) regulates haem oxygenase-1/ferritin expression: implications for toluene diisocyanate-induced asthma

Kim¹,

Choi²,

Ye³

et al. 2010

Clinical and Experimental Immunology

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SummaryDiisocyanate is a leading cause of occupational asthma (OA). Diisocyanateinduced OA is an inflammatory disease of the airways that is associated with airway remodelling. Although the pathogenic mechanisms are unclear, oxidative stress may be related to the pathogenesis of diisocyanate-induced OA. In our previous report, we observed that the expression of ferritin light chain (FTL) was decreased in both of bronchoalveolar lavage fluid and serum of patients with diphenyl-methane diisocyanate (MDI)-induced OA compared to those of asymptomatic exposed controls and unexposed healthy controls. In this study of toluene diisocyanate (TDI)-OA, we found identical findings with increased transferrin and decreased ferritin levels in the serum of patients with TDI-OA. To elucidate whether diisocyanate suppresses FTL synthesis directly, we tested the effect of TDI on the FTL synthesis in A549 cells, a human airway epithelial cell line. We found that haem oxygenase-1 as well as FTL was suppressed by treatment with TDI in dose-and timedependent manners. We also found that the synthesis of other anti-oxidant proteins such as thioredoxin-1, glutathione peroxidase, peroxiredoxin 1 and catalase were suppressed by TDI. Furthermore, TDI suppressed nuclear translocation of Nrf2 through suppressing the phosphorylation of mitogenactivated protein kinases (MAPKs); extracellular-regulated kinase 1/2 (ERK1/ 2); p38; and c-Jun N-terminal kinase (JNK). Peroxisome proliferator-activated receptor-g (PPAR-g) agonists, 15-deoxy-D 12,14 -PGJ2 and rosiglitazone rescued the effect of TDI on HO-1/FTL expression. Collectively, our findings suggest that TDI suppressed HO-1/FTL expression through the MAPK-Nrf2 signalling pathway, which may be involved in the pathogenesis of TDI-induced OA. Therefore, elucidating these observations further should help to develop the therapeutic strategies of diisocyanate-induced OA.

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Section: Discussionsupporting

confidence: 64%

“…3e,f), suggesting that TDI down-regulates the expression of anti-oxidant proteins in airway epithelial cells. Previous reports demonstrated that TDI exposure induces ROS generation [19,20]. Oxidative stress such as ROS has been known to up-regulate anti-oxidant enzymes [18,21].…”

Section: Tdi Down-regulated Ho-1 Expression In A549 Cellsmentioning

confidence: 99%

Toluene diisocyanate (TDI) regulates haem oxygenase-1/ferritin expression: implications for toluene diisocyanate-induced asthma

Kim¹,

Choi²,

Ye³

et al. 2010

Clinical and Experimental Immunology

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“…TGaseII regulates production of reactive oxygen species and secretion of Th2 cytokines and mediates in vitro and in vivo allergic inflammation (11). Tissue transglutaminase mediates airway inflammation of toluene diisocyanate-induced occupational asthma by regulating the production of reactive oxygen species (12). Epithelial TGaseII is a critical inducer of pulmonary inflammation in bleomycin-treated mice (13).…”

mentioning

confidence: 99%

Transglutaminase II/MicroRNA-218/-181a Loop Regulates Positive Feedback Relationship between Allergic Inflammation and Tumor Metastasis

Eom

Kim

et al. 2014

Journal of Biological Chemistry

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Background:The mechanism of transglutaminase II-mediated allergic inflammation-promoted tumor metastasis remains unknown at the molecular level. Results: The transglutaminase II/miR-218/-181a loop regulates allergic inflammation-promoted tumor metastasis. Conclusion: Transglutaminase II mediates a positive feedback between allergic inflammation and tumor metastasis. Significance: Transglutaminase II can be a target for the development of allergy and cancer therapeutics.

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“…41 In airway inflammation observed in toluene diisocyanate (TDI)-induced occupational asthma, TDI increased TGase activity, which was mediated by TDIinduced ROS production. 42 Therefore, a relationship between TGase and ROS in the inflammation response seems plausible. However, increases in the former activity appeared a secondary effect, and subordinate to heightened ROS.…”

Section: Ros On the Life Of Pollenmentioning

confidence: 99%

New insights into an old story

Speranza

Scoccianti

2012

Plant Signaling & Behavior

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ROS is a collective term that includes oxygen radicals (e.g., superoxide, hydroxyle, hydroperoxyle), and certain non radicals (e.g., H 2 O 2 , ozone, singlet oxygen) that are oxidising agents and/or are easily converted into radicals. These agents are continuously produced in plants and other aerobic organisms as a result of partial O 2 reduction during a number of normal metabolic processes, such as respiration, photosynthesis and photorespiration. [1][2][3][4] The ROS pool size depends on the relative rates of ROS generation and destruction, and on the life time of the main ROS species. Plants possess a complex battery of ROS scavenging enzymes (e.g., superoxide dismutase, ascorbate peroxidase, glutathione peroxidase and catalase), and low molecular non-enzymatic antioxidants (e.g., ascorbate and glutathione, but also tocopherol, flavonoids, alkaloids and carotenoids), often confined to particular compartments, that play a key role in ROS cellular control levels. 5,6 Excess ROS is harmful to many plant cell constituents, including lipids, proteins and nucleic acids, and in some case can induce plant cell death. 7,8 Several biochemical and genetic studies have emphasized the key role of ROS as PCD (apoptosis) triggers in plant cell response to specific stimuli.9,10 PCD controlled by ROS occurs during developmental processes, including aleurone cell death and leaf senescence, hypersensitive response, allelopathic plantplant interactions, and various forms of abiotic stress. 6,11,12 External adverse conditions (high light, drought, low and high temperature and mechanical stress) disrupt intracellular ROS Reactive oxygen species (ROS) can exhibit negative and benign traits. In plants, ROS levels increase markedly during periods of environmental stress and defense against pathogen attack. ROS form naturally as a by-product of normal oxygen metabolism, and evenly play an essential role in cell growth. The short ROS lifespan makes them ideal molecules to act in cell signaling, a role they share in both plants and animals. A particular plant organism, the pollen grain, may closely interact with human mucosa and an allergic inflammatory response often results. Pollen grain ROS represent a first, crucial signal which primes and magnifies a cascade of events in the allergic response. New insights into an old storyPollen ROS also play a role in hay fever Keywords: NADPH oxidase, reactive oxygen species, pollen, allergy, oxidative stress, environment pollution homeostasis.6 Interestingly, ROS/redox signaling networks in the chloroplast and mitochondria play essential roles in plant acclimation to abiotic stress via the regulation of important biological pathways, such as gene expression, energy metabolism and protein phosphorylation. 13Until recently, ROS were considered unwelcome by-products of metabolism. However, information continues to emerge on the range of ROS forms, and has demonstrated the molecules serve as important plant development and growth regulators, which operate in strict association with hormonal signal...

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Tissue Transglutaminase Can Be Involved in Airway Inflammation of Toluene Diisocyanate-Induced Occupational Asthma

Cited by 27 publications

References 41 publications

Toluene diisocyanate (TDI) regulates haem oxygenase-1/ferritin expression: implications for toluene diisocyanate-induced asthma

Toluene diisocyanate (TDI) regulates haem oxygenase-1/ferritin expression: implications for toluene diisocyanate-induced asthma

Transglutaminase II/MicroRNA-218/-181a Loop Regulates Positive Feedback Relationship between Allergic Inflammation and Tumor Metastasis

New insights into an old story

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