Tissue specificity at the time of metamorphosis in frog larvae

Schwind, Joseph L.

doi:10.1002/jez.1400660102

Cited by 18 publications

(4 citation statements)

References 4 publications

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“…In contrast, prospective adult organs such as larval eyes and hindlimb buds that have been transplanted to a tail remain even after the tail regresses completely (Schwind ; Holder ). Hindlimb buds grafted onto a tail were found to be connected to the frogs up to 14 days post‐metamorphosis (Schubert ).…”

Section: Discussionmentioning

confidence: 99%

Vitamin A induced homeotic hindlimb formation on dorsal and ventral sides of regenerating tissue of amputated tails of Japanese brown frog tadpoles

Tazawa

Yaoita

2017

Dev Growth Differ

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When anuran tadpoles are treated with vitamin A after tail amputation, hindlimb-like structures can be generated instead of the lost tail part at the amputation site. This homeotic transformation was initially expected to be a key to understanding the body plan of vertebrates. Unfortunately, homeotic limb formation has been reproduced in only some Indian frog species and a European species, but not in experimental anurans such as Xenopus laevis or Rana catesbeiana. Consequently, this fascinating phenomenon has not been well analyzed, especially at the molecular level. In addition, the initial processes of ectopic limb development are also unclear because morphological changes in the early phases have not been analyzed in detail. In this study, we report the induction of homeotic transformation using Japanese brown frogs and present a detailed morphological analysis. Unexpectedly, the ectopic limbs developed not only at the ventral sites, but also at the dorsal sites of the tail regenerates of vitamin A-treated tadpoles. The relationship between position and axial orientation of ectopic limbs suggested the double duplication of positional value order along the rostral-caudal axis and the dorsal-ventral axis of the tail regenerates.

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Section: Discussionmentioning

confidence: 99%

Vitamin A induced homeotic hindlimb formation on dorsal and ventral sides of regenerating tissue of amputated tails of Japanese brown frog tadpoles

Tazawa

Yaoita

2017

Dev Growth Differ

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“…For example, tail explants in organ culture respond to added TH by resorbing their fins (1). Tails transplanted to the lateral body wall of a tadpole resorb at the same time as the tadpole's normal tail (2), whereas eyes transplanted to the tip of the tail undergo their expected changes despite the resorption of the tail to which they are attached. Isolated hind limbs are reported to respond to TH induction (3), and the intestine begins to remodel in culture (4).…”

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confidence: 99%

Multiple thyroid hormone-induced muscle growth and death programs during metamorphosis in Xenopus laevis

Das

Schreiber

Huang

et al. 2002

Proc. Natl. Acad. Sci. U.S.A.

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Xenopus laevis tadpole tails contain fast muscle fibers oriented in chevrons and two pairs of slow muscle ''cords'' along the length of the tail. When tail resorption is inhibited by a number of different treatments, fast muscle but not the slow cord muscle still is lost, demonstrating that the fast tail muscle is a direct target of the thyroid hormone-induced death program. Expression of a dominant negative form of the thyroid hormone receptor (TRDN␣) was restricted to tadpole muscle by means of a muscle-specific promoter. Even though the transgene protects fast tail muscle from thyroid hormone (TH)-induced death, the tail shortens, and the distal muscle chevrons at the tail tip are degraded. This default pathway for muscle death is probably caused by the action of proteolytic enzymes secreted by neighboring fibroblasts. Nonmuscle tissues that are sensitive to TH, such as the fibroblasts, are not protected by the transgene when it is expressed solely in muscle. If allowed to develop to metamorphosis, these transgenic animals die at the climax of metamorphosis before tail resorption has begun. Their limbs have very little muscle even though the rest of limb morphology is normal. Thus, fast tail muscle and limb muscle have their own cell autonomous death and growth programs, respectively, that are independent of the fate of the other neighboring cell types. In contrast, death of the slow muscle is controlled by the other cell types of the tail.

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“…Humm et al (1957) have transplanted melanomas from adult platyfish-swordtail hybrids to embryos of both species and their hybrids. A close correlation has been noted between the time of parturition in mammals (e.g., Freund, 1930), hatching in birds (e.g., Murphy, 1914;Waterman, 1936) or metamorphosis in amphibians (Schwind, 1933(Schwind, , 1937Triplett, 1958) and the development of the ability to react immunologically to implanted or injected foreign materials. This difference in results could be explained in one or both of two ways.…”

Section: Discussionmentioning

confidence: 92%

Tissue Specificity in Embryonic and Adult Cymatogaster Aggregata Studied by Scale Transplantation

Triplett

Barrymore

1960

The Biological Bulletin

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Tissue specificity at the time of metamorphosis in frog larvae

Cited by 18 publications

References 4 publications

Vitamin A induced homeotic hindlimb formation on dorsal and ventral sides of regenerating tissue of amputated tails of Japanese brown frog tadpoles

Vitamin A induced homeotic hindlimb formation on dorsal and ventral sides of regenerating tissue of amputated tails of Japanese brown frog tadpoles

Multiple thyroid hormone-induced muscle growth and death programs during metamorphosis in Xenopus laevis

Tissue Specificity in Embryonic and Adult Cymatogaster Aggregata Studied by Scale Transplantation

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