Tissue-specific RNA-seq defines genes governing male tail tip morphogenesis in C. elegans
Karin C. Kiontke,
R. Antonio Herrera,
D. Adam Mason
et al.
Abstract:Caenorhabditis elegans males undergo sex-specific tail tip morphogenesis (TTM) under the control of the DM-domain transcription factor DMD-3. To find genes regulated by DMD-3, we performed RNA-seq of laser-dissected tail tips. We identified 564 genes differentially expressed (DE) in wild-type males versus dmd-3(-) males and hermaphrodites. The transcription profile of dmd-3(-) tail tips is similar to that in hermaphrodites. For validation, we analyzed transcriptional reporters for 49 genes and found male-speci… Show more
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