Abstract:Eukaryotic gene expression is regulated post-transcriptionally by a universal mechanism called unproductive splicing, in which mRNA is triggered to degradation by the nonsense-mediated decay (NMD) pathway as a result of alternative splicing (AS). Only a few dozen unproductive splicing events (USEs) are documented, and many more remain to be identified. We performed an exhaustive search to catalog experimentally-validated and annotated USEs and monitored them in a panel of RNA-seq experiments from Genotype-Tiss… Show more
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