Tissue specific oxidative stress profile in relation to glycaemic regulation in mice

Abstract

The control of hyperglycaemia improves oxidative stress profile, that is, the ability of cells to cope up with oxidative stress.

Randomised clinical trial of long term glutathione supplementation offers protection from oxidative damage, improves HbA1c in elderly type 2 diabetic patients

“…The copyright holder for this preprint this version posted April 29, 2021. ; https://doi.org/10.1101/2021.04.27.21256157 doi: medRxiv preprint capacity and a poor ability to rectify oxidatively damaged DNA (Tiedge et al,1997, Modak et al,2009Modak et al, 2014). Thus, one potential strategy towards improving glucose-stimulated insulin secretion is to provide antioxidant support to pancreatic β-cells.…”

“…It is crucial to maintain a healthy redox state of pancreatic β-cells as their ability to secrete insulin in response to glucose is dependent on intracellular and membrane thiols (Anjaneyulu et al, 1882). It is well established that β-cells are more vulnerable than other cells to hyperglycemia-mediated ROS due to their low antioxidant capacity and a poor ability to rectify oxidatively damaged DNA (Tiedge et al,1997, Modak et al,2009Modak et al, 2014). Thus, one potential strategy towards improving glucose-stimulated insulin secretion is to provide antioxidant support to pancreatic β-cells.…”

Kapsaisin Uygulanan Diabetik Sıçanların Karaciğer Dokusunda GPX 1’in Real Time-PCR ile Expresyon Profilinin Çıkarılması

“…While low levels of reactive oxygen species play a role in intracellular signaling pathways involving cell differentiation, cell progression, or halt of cell growth and apoptosis, their increasing doses such as those in oxidative stress causes metabolic disorders and damage to biological macromolecules [6] . Former studies have shown that diabetes leads to oxidative stress by lowering the antioxidant potential and increasing free radical formation rate [7] . It has been reported that hyperglycemia particularly induces oxidative stress in the cell [8,9] .…”

“…It has been reported that hyperglycemia particularly induces oxidative stress in the cell [8,9] . Oxidative stress emerges not only in diabetes, but also in certain other pathological conditions such as cardiovascular diseases, aging, cancer, and neurological disorders [7] . In human body, there are plenty of endogenous and exogenous defensive mechanisms collectively called antioxidants to prevent formation of free radicals and neutralize their detrimental effects.…”