Tissue specific opsonins for phagocytic cells and their different affinity for cholesterol‐rich liposomes

Moghimi, S. Moein; Patel, Harish M.

doi:10.1016/0014-5793(88)81372-3

Cited by 137 publications

(39 citation statements)

References 19 publications

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“…34) There are many reports regarding the binding of plasma proteins onto the surface of liposomes or emulsions and influence on their metabolic pathway. [35][36][37][38] Furthermore, the interaction of liposomes with serum components can cause the leakage of materials entrapped in the liposomes. 21,22) A number of studies have indicated that serum components increase the release efficiency of liposomes.…”

Section: Discussionmentioning

confidence: 99%

Alteration in the Temperature-Dependent Content Release Property of Thermosensitive Liposomes in Plasma

et al. 2003

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Liposomes have been proposed as carriers for the delivery of molecules to cells. They have been shown to enhance the efficacy of encapsulated drugs, prolonging the circulation time and reducing side effects. Moreover, the targeting of liposomes to desirable sites has been attempted. 1,2) In addition, a number of attempts have been made to develop functional liposomes, which can regulate the release of drugs responding to various stimuli, such as pH, [3][4][5][6] light 7,8) and temperature. 9-15)The liposomes injected into blood would be opsonized by serum components, and rapidly taken up by the reticuloendothelial system (RES) including the liver and spleen. [16][17][18][19][20] This is a major problem for researchers, because it is a significant disadvantage for the delivery of drugs to non-RES tissues. Moreover, some serum components have a destabilizing effect upon lipid vesicles and thereby cause leakage of liposomal contents. For example, high-density lipoprotein (HDL) is known to cause the disintegration of liposomes. 21,22) Yatvin et al. and Weinstein et al. reported an unique approach to controlling the release of drugs using temperaturesensitive liposomes in conjunction with local hyperthermia.9-11) The barrier efficiency of the membrane abruptly decreases near the gel-to-liquid crystalline phase transition temperature (T m ) of the phospholipid membrane. The temperature-sensitive liposomes have been designed to release a drug in response to local hyperthermia, during which a tumor was heated at temperatures of 41 to 45°C. Other strategies have been used for the production of temperature-sensitive liposomes. One example is the use of polymers, which are attached to the liposome to exhibit temperature-sensitivity and cause release of the internal content above a certain temperature. 14,15) In the development of the liposome, pharmaceutical scientists have been confronted with two difficulties. The first is how to prolong circulation time. Recently, the liposome surface has been modified with GM1 ganglioside 23) and polyoxyethylene derivatives, 24,25) which have some ability to escape the RES. The second is the problem regarding the stability of liposomes in systemic circulation after injection. In general, it is favorable for a drug delivery system (DDS) to have liposomes that are stable in the blood circulation, especially for chemotherapy and gene therapy. In addition, when trying to develop stimulus-sensitive liposomes, one should consider the influence of the serum components on the function of liposomes. Liu and Huang have observed that DOPEbased pH-sensitive liposomes lost their pH-sensitivity in the presence of serum. 26)Anionic lipids are frequently used in preparing liposomes for drug delivery. In the fluid state, negatively charged liposomes composed of phosphatidylglycerol (PG) interacted with serum components and caused an increase in the leakage of the encapsulated drug. 27) Therefore, it is necessary to investigate the effects of serum components on the temperature-dependent release propert...

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Section: Discussionmentioning

confidence: 99%

Alteration in the Temperature-Dependent Content Release Property of Thermosensitive Liposomes in Plasma

et al. 2003

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“…The major lipid components of all formulas were PC and CHO. CHO was used for almost half of the total lipids to provide more stable lipid bilayers to decrease the membrane fluidity as reported elsewhere (27,28). DCP and sodium DC were used as helper lipids to induce a negative surface charge on the liposomes.…”

Section: Chitosan-coated Liposome Preparation and Morphologymentioning

confidence: 99%

Development and Evaluation of Chitosan-Coated Liposomes for Oral DNA Vaccine: The Improvement of Peyer’s Patch Targeting Using a Polyplex-Loaded Liposomes

et al. 2010

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Abstract. The aim of this study was to develop chitosan-coated and polyplex-loaded liposomes (PLLs) containing DNA vaccine for Peyer's patch targeting. Plain liposomes carrying plasmid pRc/CMV-HBs were prepared by the reverse-phase evaporation method. Chitosan coating was carried out by incubation of the liposomal suspensions with chitosan solution. Main lipid components of liposomes were phosphatidylcholine/cholesterol. Sodium deoxycholate and dicetyl phosphate were used as negative charge inducers. The zeta potentials of plain liposomes were strongly affected by the pH of the medium. Coating with chitosan variably increased the surface charges of the liposomes. To increase the zeta potential and stability of the liposome, chitosan was also used as a DNA condensing agent to form a polyplex. The PLLs were coated with chitosan solution. In vivo study of PLLs was carried out in comparison with chitosan-coated liposomes using plasmid encoding green fluorescence protein as a reporter. A single dose of plasmid equal to 100 μg was intragastrically inoculated into BALB/c mice. The expression of green fluorescence protein (GFP) was detected after 24 h using a confocal laser scanning microscope. The signal of GFP was obtained from positively charged chitosan-coated liposomes but found only at the upper part of duodenum. With chitosan-coated PLL540, the signal of GFP was found throughout the intestine. Chitosan-coated PLL demonstrated a higher potential to deliver the DNA to the distal intestine than the chitosan-coated liposomes due to the increase in permanent positive surface charges and the decreased enzymatic degradation.

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“…67 In addition to exposure to the environmental pollutants and 68 pathogens, the lung is also exposed to drug formulations that are 69 administered for the treatment of respiratory disorders. Recent 70 advancements in the technology for drug delivery have spurred a 71 growth in inhalational drug formulations with superior therapeu- 72 tic outcomes [5].…”

mentioning

confidence: 99%

Particle engineering to enhance or lessen particle uptake by alveolar macrophages and to influence the therapeutic outcome

Patel

Gupta

Ahsan

2015

European Journal of Pharmaceutics and Biopharmaceutics

125

104

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Tissue specific opsonins for phagocytic cells and their different affinity for cholesterol‐rich liposomes

Cited by 137 publications

References 19 publications

Alteration in the Temperature-Dependent Content Release Property of Thermosensitive Liposomes in Plasma

Alteration in the Temperature-Dependent Content Release Property of Thermosensitive Liposomes in Plasma

Development and Evaluation of Chitosan-Coated Liposomes for Oral DNA Vaccine: The Improvement of Peyer’s Patch Targeting Using a Polyplex-Loaded Liposomes

Particle engineering to enhance or lessen particle uptake by alveolar macrophages and to influence the therapeutic outcome

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