Tissue-specific expression of glutathione peroxidase gene in guinea pigs

Tissue Distribution, Molecular Cloning, and Gene Expression of Cytosolic Glutathione Peroxidase in Japanese Monkey

“…The expressional pattern of GPX-1 gene in Japanese monkey appeared similar to those of human (Chambers et al ., 1986;Chu, 1993), mouse, and rat (Ho and Howard, 1992;Lei et al ., 1995;Munz et al ., 1997). However, the GPX-1 mRNA level in guinea pig was reported to be low in the liver, kidney, and heart (Himeno et al ., 1993a), showing a distinct species-specificity in expression.…”

(S)-Preferential detoxification of 4-hydroxy-2(E)-nonenal enantiomers by hepatic glutathione S-transferase isoforms in guinea-pigs and rats

“…It is well known that the guinea-pig has no detectable levels of Se-GSH Px in its major tissues, including the liver [23,24]. Oshino et al [51] demonstrated that the homodimeric enzyme gpGSTa, a major hepatic GST re-designated as gpGSTA1-1 in the present study, had extremely high GSH Px activity towards cumene hydroperoxide and linoleic acid hydroperoxide.…”

“…It is well known that guinea-pigs have no detectable level of selenium-containing glutathione peroxidase (Se-GSH Px) in their tissues or organs but that their erythrocytes contain significant levels of this enzyme with activity comparable with that of erythrocyte Se-GSH Px in other mammals [23,24]. Se-GSH Px has potent specific activity towards hydroperoxides of arachidonic and linoleic acids [25], both of which are precursors of racemic HNE [2].…”

Ferroportin inhibition attenuates plasma iron, oxidant stress, and renal injury following red blood cell transfusion in guinea pigs

“…Therefore, translational aspects of RBC physiology that may apply to humans are relevant to the present study. Further, guinea pigs demonstrate tissue enzymatic antioxidant concentrations and activities (unique from other rodents and dogs) that more closely align with humans . The kidney represents an important end organ of interest in guinea pigs following hemolysis and Hb degradation product exposures.…”

“…Further, guinea pigs demonstrate tissue enzymatic antioxidant concentrations and activities (unique from other rodents and dogs) that more closely align with humans. 28,29 The kidney represents an important end organ of interest in guinea pigs following hemolysis and Hb degradation product exposures. Like humans, guinea pigs are susceptible to tissue injury caused by heme proteins during rhabdomyolysis, 30 cardiopulmonary bypass/extracorporeal circulation, 31 and thrombotic microangiopathy with hemolytic uremic syndrome.…”