Tissue specific distribution of Epstein-Barr virus (EBV) BZLF1 gene variants in nasopharyngeal carcinoma (NPC) bearing patients

Nasopharyngeal carcinoma: A review

“…193 Based on genotyping polymorphic markers in EBER1 and 2, LMP1, BHRF1, BZLF1, and EBNA gene loci, different EBV strains have been characterized in tumor tissue from various geographic regions. [194][195][196][197][198][199] Moreover, EBV harbors different genetic variations in different ethnic and geographic poulations. [200][201][202][203][204][205][206][207][208] There is an association between the LMP1 deletion variant Asp 335 and NPC patients (tumor tissue) in Hong Kong.…”

The extent of genetic diversity of Epstein-Barr virus and its geographic and disease patterns: A need for reappraisal

“… (Berger et al, 1999; Chang et al, 2006; Chang et al, 1995; Chen et al, 1996b; Cheung et al, 1998; Cheung et al, 1996; Chiang et al, 1999; Correa et al, 2004; D’Addario and Chauvin, 2000; Dolcetti et al, 1997; Fassone et al, 2002; Guiretti et al, 2007; Gutierrez et al, 2000; Hayashi et al, 1997; Itakura et al, 1996; Jeon et al, 2004; Khanim et al, 1996; Lin et al, 2004; Lindsey et al, 2008; Nguyen-Van et al, 2008; Plaza et al, 2003; Sandvej et al, 1997; Santon and Bellas, 2001; Santon et al, 1995; See et al, 2008; Sung et al, 1998; Tan et al, 2003; Tang et al, 2008; Tao et al, 1998; Tiwawech et al, 2008; Trimeche et al, 2007; Vallat-Decouvelaere et al, 2002; Zhang et al, 2002; Zhou et al, 2001) (Barozzi et al, 1999; Berger et al, 1999; Chang et al, 1995; Cheung et al, 1996; Khanim et al, 1996; Lin et al, 2004; Lin et al, 1995; Lin et al, 2003; Santon and Bellas, 2001; See et al, 2008; Shu and Tu, 2000; Tan et al, 2003; Tang et al, 2008; Zhou et al, 2001) …”

“… (Barozzi et al, 1999; Berger et al, 1999; Chang et al, 1995; Cheung et al, 1996; Khanim et al, 1996; Lin et al, 2004; Lin et al, 1995; Lin et al, 2003; Santon and Bellas, 2001; See et al, 2008; Shu and Tu, 2000; Tan et al, 2003; Tang et al, 2008; Zhou et al, 2001) …”

Epstein–Barr virus in the pathogenesis of NPC

“…47 Several studies have suggested that normal individuals harbor multiple EBV variants and others have shown evidence of distinct compartments of EBV infection. [48][49][50] In an interesting case study, EBV replication was detected in the epithelial cells surrounding an EBV positive T-cell lymphoma within the parotid gland that was latently infected. 51 The unusual lesion, hairy leukoplakia, that may develop in immunocompromized individuals is a completely permissive infection and the lesion regresses with antiviral therapy.…”