Tissue-Specific Control of Tissue-Resident Memory T Cells

Liu, Yong; Ma, Chaoyu; Zhang, Nu

doi:10.1615/critrevimmunol.2018025653

Cited by 30 publications

(30 citation statements)

References 191 publications

(298 reference statements)

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“…The vast majority of influenza virus-specific CD4 T cells had CD69 + CD103phenotype, which is in line with previous findings that the CD4 T RM cells usually express CD11a instead of CD103 marker (Liu et al, 2018) (Fig. 6A).…”

Section: Recombinant Laiv-rsv Viruses Induce Memory T Cells Specific supporting

confidence: 92%

“…CD103, a mucosal lymphocyte surface marker integrin αEβ7, and CD69 have been widely accepted as the common markers of tissue-resident cells in mucosal and some non-mucosal tissues (Liu et al, 2018). Seven days after the second immunization, the levels of effector memory CD4 T cells expressing CD69 early activation marker were not significantly higher in the lungs of immunized mice than in those of the control group (Fig.…”

Section: Recombinant Laiv-rsv Viruses Induce Robust Cd8 T-cell Responmentioning

confidence: 92%

“…This is somewhat surprising because CD103 is usually expressed only by some subsets of CD8 T RM (Mueller and Mackay, 2016). Nevertheless, several studies have identified distinct populations of CD4 T cells that carry typical T RM markers in both mouse and human lungs, with the CD4 T RM cells usually carrying less CD103 or expressing CD11a instead of CD103 (reviewed in (Liu et al, 2018)). In this study, the CD69 + CD103 + CD4 Tem cells were induced only by the recombinant viruses carrying RSV epitopes, and not by LAIV alone, which suggests that the RSV cassette is involved in the formation of CD4 T RM cells after prime-boost immunization.…”

Section: Recombinant Laiv-rsv Viruses Induce Robust Cd8 T-cell Responmentioning

confidence: 99%

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Conserved T-cell epitopes of respiratory syncytial virus (RSV) delivered by recombinant live attenuated influenza vaccine viruses efficiently induce RSV-specific lung-localized memory T cells and augment influenza-specific resident memory T-cell responses

et al. 2020

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Section: Recombinant Laiv-rsv Viruses Induce Memory T Cells Specific supporting

confidence: 92%

Section: Recombinant Laiv-rsv Viruses Induce Robust Cd8 T-cell Responmentioning

confidence: 92%

Section: Recombinant Laiv-rsv Viruses Induce Robust Cd8 T-cell Responmentioning

confidence: 99%

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Conserved T-cell epitopes of respiratory syncytial virus (RSV) delivered by recombinant live attenuated influenza vaccine viruses efficiently induce RSV-specific lung-localized memory T cells and augment influenza-specific resident memory T-cell responses

et al. 2020

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“…In addition to these differences in the structure of the epithelium, there are differences in the complexity and makeup of the microbiota at different mucosal tissue sites, which may also contribute to tissue-specific environmental differences that could affect memory CD8 T cell differentiation and function. In line with these differences between the vagina and mucosal tissues such as the gut, a possible explanation for the observed delay in canonical resident-memory differentiation is that the CVT tissue microenvironment is deficient in signals that are important for resident-memory formation and maintenance (31).…”

Section: Discussionmentioning

confidence: 99%

Cervicovaginal tissue residence imprints a distinct differentiation program upon memory CD8 T cells

Davé¹,

Cardozo-Ojeda

Mair³

et al. 2019

Preprint

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26The memory CD8 T cell compartment in human cervicovaginal tissue (CVT) is phenotypically 27 and functionally distinct compared to other non-lymphoid tissues. To determine if these 28 distinctive features are driven by residence in the tissue itself, rather than a consequence of 29 local antigenic insults, we used a mouse model to assess memory CD8 T cell differentiation in 30 the CVT. Following systemic immunization to elicit a CD8 T cell response to a herpes simplex 31 virus (HSV) epitope, HSV-specific memory CD8 T cells were stably maintained in other tissues 32 but gradually declined in the CVT over 5 months post-immunization, correlating with a delay in 33 viral control upon HSV challenge. While memory cells in the periphery and small intestine 34 maintained a fairly stable phenotype after 30 days, memory CD8 T cells in the CVT gradually 35 acquired a CD103 + , TCF-1 -, granzyme B + phenotype over the 5 month time span. Notably, a 36 sizable and phenotypically similar population of CD8 T cells was also found in human CVT. Our 37 data indicate that the CVT environment itself considerably affects memory CD8 T cell 38 maintenance and differentiation, and call for a reassessment of the prevalent model of memory 39 T cell maintenance which does not currently account for tissue-specific divergence. 40Pathogens that infect mucosal barrier surfaces represent a significant global health 43 burden, yet immune cell function within reproductive mucosal tissues remains understudied. In 44 addition, the phenotypic and functional characteristics of memory T cells in cervicovaginal tissue 45 (CVT) compared to other mucosal and lymphoid organs is poorly understood, despite the 46 potentially broad importance of this cellular population in the context of sexually-transmitted 47 infections. 48We recently reported that memory CD8 T cells in the human CVT displayed unique 49 phenotypical and functional features including the presence of a subset of CD69 -CD103 -50 inflammatory CD8 T cells (1). Importantly, the majority of memory CD8 T cells in the CVT of 51 healthy women typically expressed CD103 and CD69, which are biomarkers associated with 52 tissue-residence (2-4), suggesting that most memory CD8 T cells in the human CVT stably 53 reside there. Tissue-residence itself can affect functional and phenotypical properties of T cells 54 (5)(6)(7)(8)(9)(10)(11)(12)(13), which is thought to be a consequence of exposure to metabolites, cytokines, and other 55 factors present in the tissue environment in steady state conditions(14, 15) (16). However, it is 56 unclear if the distinctive features of memory CD8 T cells in the CVT are a consequence of 57 recurring local infections and antigenic insults or driven by residence in the tissue itself. To 58 address this question, we used a mouse model system to assess memory CD8 T cell 59 differentiation and maintenance in the CVT. Specifically, we used a systemic immunization 60 strategy to induce HSV-specific memory CD8 T cells. We then tracked these antigen-specific T 61 cells across tissu...

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“…The CD44 antigen is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion, and migration [83]. The most well-studied function of CD44 is as a receptor for hyaluronic acid, a component of the extracellular matrix.…”

Section: Cd44mentioning

confidence: 99%

Resident Memory T Cells

Akbaba¹

2020

Cells of the Immune System

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Until recently, T cells were thought to remain in circulation until recruitment of the inflammation and only a small number of T cells remained in the peripheral tissues without inflammation. However, studies have found that a group of T cells settled in the tissues and remained there for a long time. Those cells are named as tissue-resident memory T cells (TRM). TRM cells are transcriptionally, phenotypically, and functionally distinct from other T cells, which recirculate between blood, secondary lymphoid organs, and non-lymphoid tissues. They undergo a distinct proliferation that discriminates them from circulating T cells and their main cell surface markers are CD69, CD103, and CD49a. Upon exposure to the same or similar diseases, TRM cells provide a first line of adaptive cellular defense against infection in peripheral non-lymphoid tissues, such as skin, lungs, digestive, and urogenital tracts. This approach forms the basis of a novel vaccination strategy called "prime and pull", which ensures long-term local immunity. On the other hand, abnormal activated and malignant TRM may contribute to numerous human inflammatory diseases such as psoriasis and vitiligo. Here in this chapter, we aimed to emphasize TRM cell location, migration, phenotypic structure, maintenance, and diseases associated with TRM cells.

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Tissue-Specific Control of Tissue-Resident Memory T Cells

Cited by 30 publications

References 191 publications

Conserved T-cell epitopes of respiratory syncytial virus (RSV) delivered by recombinant live attenuated influenza vaccine viruses efficiently induce RSV-specific lung-localized memory T cells and augment influenza-specific resident memory T-cell responses

Conserved T-cell epitopes of respiratory syncytial virus (RSV) delivered by recombinant live attenuated influenza vaccine viruses efficiently induce RSV-specific lung-localized memory T cells and augment influenza-specific resident memory T-cell responses

Cervicovaginal tissue residence imprints a distinct differentiation program upon memory CD8 T cells

Resident Memory T Cells

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