Tissue-specific bioconcentration of antidepressants in fish exposed to effluent from a municipal sewage treatment plant

Grabicová, Kateřina; Lindberg, Richard H.; Östman, Marcus; Grabic, Roman; Randák, Tomáš; Larsson, D. G. Joakim; Fick, Jerker

doi:10.1016/j.scitotenv.2014.04.052

Cited by 109 publications

(69 citation statements)

References 43 publications

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“…role of liver as the primary site of xenobiotic metabolism, the higher lipid content and the large quantity of blood retained in the liver. The maximum BCF values in the present study were higher than those reported by Grabicova et al (2014), where sertraline concentrations in the liver and brain of fish exposed to undiluted effluent containing 53 ng L À1 sertraline from a municipal sewage treatment plant for 13 d were found to be 85 and 180 times higher than water concentrations, respectively. In another study, Lajeunesse et al (2011) obtained BCF values of 264 in liver, 191 in brain and 109 in muscle after exposing brook trout to 20% effluent containing 1.1 ng L À1 sertraline for 3 months.…”

Section: Tissue Distribution and Bioconcentrationcontrasting

confidence: 88%

Behavioral and biochemical responses in freshwater fish Carassius auratus exposed to sertraline

Xie

et al. 2015

Chemosphere

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Section: Tissue Distribution and Bioconcentrationcontrasting

confidence: 88%

Behavioral and biochemical responses in freshwater fish Carassius auratus exposed to sertraline

Xie

et al. 2015

Chemosphere

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“…[6,14,19] However, uptake of some pharmaceuticals has been shown to be species-, pharmaceutical-and tissue-specific. [20][21][22] For example, uptake in muscle tissue has been reported to be low when compared with the uptake in liver and brain, which may be up to 25-fold higher. [23] Therefore, measuring levels of psychiatric pharmaceuticals in the target organ, i.e.…”

Section: Introductionmentioning

confidence: 99%

“…[23] Therefore, measuring levels of psychiatric pharmaceuticals in the target organ, i.e. the brain, may be more sensitive and informative, [21,24] and the relationship between brain and blood concentrations can be used as an indicator for transportability of the investigated substance to the brain. [22] Presuming a similar mode of action for the pharmaceutical's pharmacological effect, fish blood and brain concentrations can be compared with effect concentrations in these same tissues (blood and brain) from mammalian studies to estimate the probability for environmental effects and critical water concentrations, i.e.…”

Section: Introductionmentioning

confidence: 99%

Tissue-specific uptake of the benzodiazepine oxazepam in adult Eurasian perch (Perca fluviatilis)

et al. 2016

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Environmental context. Although pharmaceuticals are found in wild fish, there is no consensus as to which fish tissue to use when measuring the pharmaceutical concentrations. Using the psychiatric pharmaceutical oxazepam in Eurasian perch as an example, we found that oxazepam was distributed in the perch tissues in the following order of concentration: muscle , liver ¼ brain , blood plasma. These results help to interpret and compare previous studies, and provide guidance for future studies.Abstract. Psychoactive substances are used worldwide and constitute one of the common groups of pharmaceutical contaminants in surface waters. Typically, in field surveys and laboratory studies, muscle or whole-body homogenates are used to quantify pharmaceutical concentrations in biota, although uptake of pharmaceuticals may be tissue-specific. Therefore, the aim of this study was to investigate the tissue-specific (muscle, liver, brain and blood plasma) uptake of the anxiolytic oxazepam in adult Eurasian perch (Perca fluviatilis). In laboratory experiments, perch were exposed to four different concentrations (2, 4, 12 and 20 mgL À1 ) of oxazepam for 6 days, and muscle, liver, brain tissue and blood plasma were sampled to determine tissue-specific bioconcentration. We found that the tissue-specific bioconcentration was independent of oxazepam concentration. However, among tissue types, bioconcentration was significantly different, with the concentration in muscle , liver ¼ brain , blood plasma. Hence, it is important to consider the type of tissue used to quantify pharmaceutical uptake in fish, for predictions of species-specific sensitivity and comparisons across studies. Furthermore, our results indicate a somewhat lower transportability (brain/plasma ratio 0.54) of oxazepam from blood to brain in fish compared with in mammals, which should be kept in mind when employing 'read-across' approaches.

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“…Bioaccumulation of human pharmaceuticals has been observed in aquatic organisms globally [12][13][14][15][16][17]. Physicochemical properties of pharmaceuticals and other contaminants of emerging concern dictate an advancement of historical approaches to define bioaccumulation, hazards, and risks [16].…”

Section: Introductionmentioning

confidence: 99%

Bioaccumulation of human pharmaceuticals in fish across habitats of a tidally influenced urban bayou

Haddad

Luek

et al. 2015

Enviro Toxic and Chemistry

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Though pharmaceuticals and other contaminants of emerging concern are increasingly observed in inland water bodies, the occurrence and bioaccumulation of pharmaceuticals in estuaries and coastal ecosystems are poorly understood. In the present study, bioaccumulation of select pharmaceuticals and other contaminants of emerging concern was examined in fish from Buffalo Bayou, a tidally influenced urban ecosystem that receives effluent from a major (∼200 million gallons per day) municipal wastewater treatment plant in Houston, Texas, USA. Using isotope dilution liquid chromatography-tandem mass spectrometry, various target analytes were observed in effluent, surface water, and multiple fish species. The trophic position of each species was determined using stable isotope analysis. Fish tissue levels of diphenhydramine, which represented the only pharmaceutical detected in all fish species, did not significantly differ between freshwater and marine fish predominantly inhabiting benthic habitats; however, saltwater fish with pelagic habitat preferences significantly accumulated diphenhydramine to the highest levels observed in the present study. Consistent with previous observations from an effluent-dependent freshwater river, diphenhydramine did not display trophic magnification, which suggests site-specific, pH-influenced inhalational uptake to a greater extent than dietary exposure in this tidally influenced urban ecosystem. The findings highlight the importance of understanding differential bioaccumulation and risks of ionizable contaminants of emerging concern in habitats of urbanizing coastal systems.

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Tissue-specific bioconcentration of antidepressants in fish exposed to effluent from a municipal sewage treatment plant

Cited by 109 publications

References 43 publications

Behavioral and biochemical responses in freshwater fish Carassius auratus exposed to sertraline

Behavioral and biochemical responses in freshwater fish Carassius auratus exposed to sertraline

Tissue-specific uptake of the benzodiazepine oxazepam in adult Eurasian perch (Perca fluviatilis)

Bioaccumulation of human pharmaceuticals in fish across habitats of a tidally influenced urban bayou

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