Tissue schistosomiasis in accra ghana: a retrospective histopathologic review at the korle-bu teaching hospital (2004-2011)

Der, Edmund Muonir; Quayson, Solomon; Mensah, James E.; Tettey, Yao

doi:10.7243/2052-7896-3-1

Cited by 7 publications

(9 citation statements)

References 26 publications

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“…This study found Schistosoma haematobium infection in 66 out of the 367 children (representing 18%), indicating that urinary schistosomiasis continues to be a disease of great public health importance, especially in children. S. haematobium infection in children has been observed to cause stunting and wasting, which are commonly unacknowledged morbidity [10, 31–33]. In a study by Botelho et al [32], the proportion of all children and adolescents who had body mass index (BMI) less than 15 kg/m 2 increased from 57.78% to 66.67% in S. haematobium -infected children, who were more stunted and wasted than in noninfected children.…”

Section: Discussionmentioning

confidence: 99%

“…Schistosoma worm and egg-derived estrogen-like molecules and their metabolites have been postulated as the main carcinogenic substances implicated in schistosomiasis-linked cancers [34]. A retrospective study done in Accra associated 20.5% of cancer cases with tissue schistosomiasis, where the urinary bladder was the most commonly (93.6%) affected organ [31]. Their study also found 98.7% of all tissue schistosomiasis to be caused by S. haematobium [31].…”

Section: Discussionmentioning

confidence: 99%

“…A retrospective study done in Accra associated 20.5% of cancer cases with tissue schistosomiasis, where the urinary bladder was the most commonly (93.6%) affected organ [31]. Their study also found 98.7% of all tissue schistosomiasis to be caused by S. haematobium [31]. With the retrospective study in mind, and the findings from the current study, it can be inferred that the possibility of some of the S. haematobium -infected pupils (especially those who had squamous cell metaplasia), having the risk of developing cancer later in life, cannot be overlooked.…”

Section: Discussionmentioning

confidence: 99%

“…While the specimen used for the retrospective study was from clinical cases, seemingly healthy children were used in the current study. Therefore, it is important to note that if this seemingly “benign” Schistosoma infection is left untreated in these children now, there is a probability of some of them having a future (with respect to developing cancer) similar to that of the subjects in the study by Der et al [31].…”

Section: Discussionmentioning

confidence: 99%

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Cytological and Wet Mount Microscopic Observations Made in Urine ofSchistosoma haematobium-Infected Children: Hint of the Implication in Bladder Cancer

Tetteh-Quarcoo

Akuetteh

Owusu

et al. 2019

Canadian Journal of Infectious Diseases and Medical Microbiolog

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Background. Schistosomiasis is the second major human parasitic disease next to malaria, in terms of socioeconomic and public health consequences, especially in sub-Saharan Africa. Schistosoma haematobium (S. haematobium) is a trematode and one of the species of Schistosoma that cause urogenital schistosomiasis (urinary schistosomiasis). Although the knowledge of this disease has improved over the years, there are still endemic areas, with most of the reported cases in Africa, including Ghana. Not much has been done in Ghana to investigate cytological abnormalities in individuals within endemic communities, although there are epidemiologic evidences linking S. haematobium infection with carcinoma of the bladder. Aim. The aim of this study was to identify microscopic and cytological abnormalities in the urine deposits of S. haematobium-infected children. Methodology. Three hundred and sixty-seven (367) urine samples were collected from school children in Zenu and Weija communities. All the samples were examined microscopically for the presence of S. haematobium eggs, after which the infected samples and controls were processed for cytological investigation. Results. S. haematobium ova were present in 66 (18.0%) out of the 367 urine samples. Inflammatory cells (82%, 54/66), hyperkeratosis (47%, 31/66), and squamous cell metaplasia (24%, 16/66) were the main observations made during the cytological examination of the S. haematobium-infected urine samples. Conclusion. Cytological abnormalities in S. haematobium-infected children may play an important role in the severity of the disease, leading to the possible development of bladder cancer in later years, if early attention is not given. Therefore, routine cytological screening for urogenital schistosomiasis patients (especially children) at hospitals in S. haematobium-endemic locations is recommended.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Cytological and Wet Mount Microscopic Observations Made in Urine ofSchistosoma haematobium-Infected Children: Hint of the Implication in Bladder Cancer

Tetteh-Quarcoo

Akuetteh

Owusu

et al. 2019

Canadian Journal of Infectious Diseases and Medical Microbiolog

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“…4 It is primarily a disease of genitourinary and hepato-biliary systems; however the disease can affect other organs/systems in the body. 5 Globally, Schistosomiasis of vermiform appendix is a very rare in developed countries and mostly reported in patients that had recent history of travelling to schistosomiasis endemic regions. [6][7][8] In endemic areas appendicular Schistosomiasis is uncommon.…”

Section: Introductionmentioning

confidence: 99%

Histopathological analysis of schistosomal appendicitis in Kano North-Western Nigeria

Haruna¹,

Bello²

2021

IJPO

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Background: Schistosomiasis is a chronic granulomatous inflammation affecting many organs and systems of the body including the gastrointestinal tract with frequent involvement of the appendix. It presents with clinical diagnostic challenge without biopsy and histopathologic evaluation. The study aims to documents the histopathologic pattern of the appendiceal schistosomiasis in our environment. Material and Methods: A 15-year (2004 to 2018) review of all appendix specimens received in the department of Histopahology, Aminu Kano University Teaching Hospital. Information on age, sex and duration of disease was retrieved from request cards and patient case notes. Cases with histological evidence of Schistosomiasis were selected for the study. Data presented as frequency distribution tables, charts and photomicrographs. Results: Thirty six (36) cases of histopathologically confirmed Schistosomal appendicitis constituting 3.2% of all appendectomy specimen with male to female ratio of 9:1, and peak incidence in the third decade of life. Majority (83.3%) of cases show granuloma formation with either calcified or viable schistosoma ova or both. Only 6 cases show Minimal inflammatory response and calcified schistosoma ova. The most common presentation was recurrent and acute appendicitis. Conclusion: Appendiceal schistosomiasis constitutes 3.2% of appendiceal lesions in our settings, affecting predominantly young male. High index of suspicions is therefore advocated in all cases of acute recurrent abdominal pains to avoid unnecessary surgical trauma.

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Preventing the Spread of Schistosomiasis in Ghana: Possible Outcomes of Integrated Optimal Control Strategies

Zhang

Harvim

Georgescu³

2017

J. Biol. Syst.

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The goal of a future free from schistosomiasis in Ghana can be achieved through integrated strategies, targeting simultaneously several stages of the life cycle of the schistosome parasite. In this paper, the transmission of schistosomiasis is modeled as a multi-scale 12-dimensional system of ODEs that includes vector-host and within-host dynamics of infection. An explicit expression for the basic reproduction number [Formula: see text] is obtained via the next generation method, this expression being interpreted in biological terms, as well as in terms of reproductive numbers for each type of interaction involved. After discussing the stability of the disease-free equilibrium and the existence and uniqueness of the endemic equilibrium, the Center Manifold Theory is used to show that for values of [Formula: see text] larger than 1, but close to 1, the unique endemic equilibrium is locally asymptotically stable. A sensitivity analysis indicates that [Formula: see text] is most sensitive to the natural death rate of the vector population, while numerical simulations of optimal control strategies reveal that the most effective strategy for the control and possible elimination of schistosomiasis should combine sanitary measures (access to safe water, improved sanitation and hygiene education), large-scale treatment of infected population and vector control measures (via the use of molluscicides), for a significant amount of time.

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Tissue schistosomiasis in accra ghana: a retrospective histopathologic review at the korle-bu teaching hospital (2004-2011)

Cited by 7 publications

References 26 publications

Cytological and Wet Mount Microscopic Observations Made in Urine ofSchistosoma haematobium-Infected Children: Hint of the Implication in Bladder Cancer

Cytological and Wet Mount Microscopic Observations Made in Urine ofSchistosoma haematobium-Infected Children: Hint of the Implication in Bladder Cancer

Histopathological analysis of schistosomal appendicitis in Kano North-Western Nigeria

Preventing the Spread of Schistosomiasis in Ghana: Possible Outcomes of Integrated Optimal Control Strategies

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