2010
DOI: 10.1002/wnan.100
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Tissue scaffolds for skin wound healing and dermal reconstruction

Abstract: One of the major applications of tissue-engineered skin substitutes for wound healing is to promote the healing of cutaneous wounds. In this respect, many important clinical milestones have been reached in the past decades. However, currently available skin substitutes for wound healing often suffer from a range of problems including wound contraction, scar formation, and poor integration with host tissue. Engineering skin substitutes by tissue engineering approach has relied upon the creation of three-dimensi… Show more

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Cited by 566 publications
(452 citation statements)
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References 135 publications
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“…To overcome these problems, several acellular matrices, such as Dermagraft ® (Organogenesis Inc.) or Integra ® (Integra Life Sciences), have been bioengineered as off-the-shelf products for the initial coverage of extensive dermal defects (Zhong et al, 2010;Graham et al, 2013;Debels et al, 2015;Singer et al, 2015). As these dermal substitutes degrade over time, their porous structures not only provide mechanical support, but also promote cellular infiltration and vascular ingrowth from the surrounding host tissue, leading to a vascularised wound bed for the final coverage with STSG (Awad et al, 2000) after 3 weeks.…”
Section: Introductionmentioning
confidence: 99%
“…To overcome these problems, several acellular matrices, such as Dermagraft ® (Organogenesis Inc.) or Integra ® (Integra Life Sciences), have been bioengineered as off-the-shelf products for the initial coverage of extensive dermal defects (Zhong et al, 2010;Graham et al, 2013;Debels et al, 2015;Singer et al, 2015). As these dermal substitutes degrade over time, their porous structures not only provide mechanical support, but also promote cellular infiltration and vascular ingrowth from the surrounding host tissue, leading to a vascularised wound bed for the final coverage with STSG (Awad et al, 2000) after 3 weeks.…”
Section: Introductionmentioning
confidence: 99%
“…cultured human skin cells, and a substrate (matrix, scaffold), being an analogue of the extracellular matrix [4].…”
Section: The Structure Of Skin Equivalentsmentioning
confidence: 99%
“…SE are used to restore the structure and, consequently, the barrier function of the skin (the main goal of burn patient treatment), and for the initiation of wound healing (in chronic non-healing wounds). Employment of SE hastens wound healing, reduces a pain syndrome, inflammation, and prevent formation of scars, contracture or pigment defects [4].…”
Section: The Structure Of Skin Equivalentsmentioning
confidence: 99%
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“…Cartilage [1], bone [1,2], blood vessels [3], skin [4], and liver [5] are only some examples of reproduced tissues that have been reported in the past decade. Fabrication of tissue engineering constructs usually begins with producing three-dimensional scaffolds representing a structural support for living cells.…”
Section: Introductionmentioning
confidence: 99%