Tissue responses to implanted materials

Dimarakis, Ioannis; Rehman, Sara; Asimakopoulos, Georgios

doi:10.1533/9780857090553.1.3

Cited by 2 publications

(3 citation statements)

References 74 publications

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“…However, the majority of polymers used in these devices (e.g., polypropylene, polyethylene, poly(vinyl chloride) (PVC), polyurethane (PU), silicone rubbers, and natural rubbers) have much higher elastic moduli (e.g., Young's modulus of 1 MPa to 1 GPa) than that of soft tissues in human body (e.g., Young's modulus of 1 to 100 kPa) . This stark mismatch in mechanical properties, coupled with the lack of biofunctionality, gives rise to numerous issues and complications during their clinical use such as tissue trauma, biofouling, thrombosis, and foreign‐body reaction . To address these shortcomings, it is necessary to modify the device surfaces to better match the properties of biological tissues …”

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confidence: 99%

“…This stark mismatch in mechanical properties, coupled with the lack of biofunctionality, gives rise to numerous issues and complications during their clinical use such as tissue trauma, biofouling, thrombosis, and foreign‐body reaction . To address these shortcomings, it is necessary to modify the device surfaces to better match the properties of biological tissues …”

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confidence: 99%

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Multifunctional “Hydrogel Skins” on Diverse Polymers with Arbitrary Shapes

et al. 2018

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Slippery and hydrophilic surfaces find critical applications in areas as diverse as biomedical devices, microfluidics, antifouling, and underwater robots. Existing methods to achieve such surfaces rely mostly on grafting hydrophilic polymer brushes or coating hydrogel layers, but these methods suffer from several limitations. Grafted polymer brushes are prone to damage and do not provide sufficient mechanical compliance due to their nanometer‐scale thickness. Hydrogel coatings are applicable only for relatively simple geometries, precluding their use for the surfaces with complex geometries and features. Here, a new method is proposed to interpenetrate hydrophilic polymers into the surface of diverse polymers with arbitrary shapes to form naturally integrated “hydrogel skins.” The hydrogel skins exhibit tissue‐like softness (Young's modulus ≈ 30 kPa), have uniform and tunable thickness in the range of 5–25 µm, and can withstand prolonged shearing forces with no measurable damage. The hydrogel skins also provide superior low‐friction, antifouling, and ionically conductive surfaces to the polymer substrates without compromising their original mechanical properties and geometry. Applications of the hydrogel skins on inner and outer surfaces of various practical polymer devices including medical tubing, Foley catheters, cardiac pacemaker leads, and soft robots on massive scales are further demonstrated.

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confidence: 99%

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confidence: 99%

Multifunctional “Hydrogel Skins” on Diverse Polymers with Arbitrary Shapes

et al. 2018

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“…However, during senescence, the cells are in a state of irreversible growth arrest driven by presence of persistent DNA damage, high concentration of reactive oxygen species (ROS), mitochondrial dysfunction, and an overall inflammatory milieu. , Effects of senescent cells and associated inflammation include the recruitment of immune cells for their clearance, which disrupts normal tissue structure and function if left unresolved. Furthermore, implantation of a biomedical device/product in a geriatric patient can induce additional stress over and above the existing senescent microenvironment due to aging. − There is a limited understanding of how biomaterial properties influence the senescence status of the cells. Previously, inherent differences were reported in senescent cell behavior when cultured on soft, porous scaffolds compared to conventional two-dimensional (2D) tissue culture plates .…”

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confidence: 99%

Cellular Senescence Program is Sensitive to Physical Differences in Polymeric Tissue Scaffolds

Yadav,

Shah,

Roy

et al. 2023

ACS Mater. Au

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A typical cellular senescence program involves exposing cells to DNA-damaging agents such as ionization radiation or chemotherapeutic drugs, which cause multipronged changes, including increased cell size and volume, the onset of enhanced oxidative stress, and inflammation. In the present study, we examined if the senescence onset decision is sensitive to the design, porosity, and architecture of the substrate. To address this, we generated a library of polymeric scaffolds widely used in tissue engineering of varied stiffness, architecture, and porosity. Using irradiated A549 lung cancer cells, we examined the differences between cellular responses in these 3D scaffold systems and observed that senescence onset is equally diminished. When compared to the two-dimensional (2D) culture formats, there were profound changes in cell size and senescence induction in three-dimensional (3D) scaffolds. We further establish that these observed differences in the senescence state can be attributed to the altered cell spreading and cellular interactions on these substrates. This study elucidates the role of scaffold architecture in the cellular senescence program.

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Tissue responses to implanted materials

Cited by 2 publications

References 74 publications

Multifunctional “Hydrogel Skins” on Diverse Polymers with Arbitrary Shapes

Multifunctional “Hydrogel Skins” on Diverse Polymers with Arbitrary Shapes

Cellular Senescence Program is Sensitive to Physical Differences in Polymeric Tissue Scaffolds

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