Tissue Response to Titanium Implants in the Rat Maxilla: Ultrastructural and Histochemical Observations of the Bone‐Titanium Interface

Futami, Takayuki; Fujii, Noritaka; Ohnishi, Hideo; Taguchi, Naoyuki; Kusakari, Haruka; Ohshima, Hayato; Maeda, Takeyasu

doi:10.1902/jop.2000.71.2.287

Cited by 113 publications

(150 citation statements)

References 26 publications

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“…Woven bone is reported to be progressively remodeled and substituted by mature bone with a trabecular structure and delimiting marrow spaces later on [50], a process that also removes bone debris and necrotized bone caused by the implant bed preparation [51]. In the present study, the remodeling was initiated by a significant loss in bone volume in the bone-healing-zone that started 10 days after screw implantation in the Control-group.…”

Section: Discussionmentioning

confidence: 49%

Does locally delivered Zoledronate influence peri-implant bone formation? – Spatio-temporal monitoring of bone remodeling in vivo

Kettenberger

Ston

Thein³

et al. 2014

Biomaterials

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a b s t r a c tBisphosphonates are known for their strong inhibitory effect on bone resorption. Their influence on bone formation however is less clear. In this study we investigated the spatio-temporal effect of locally delivered Zoledronate on peri-implant bone formation and resorption in an ovariectomized rat femoral model. A cross-linked hyaluronic acid hydrogel was loaded with the drug and applied bilaterally in predrilled holes before inserting polymer screws. Static and dynamic bone parameters were analyzed based on in vivo microCT scans performed first weekly and then biweekly. The results showed that the locally released Zoledronate boosted bone formation rate up to 100% during the first 17 days after implantation and reduced the bone resorption rate up to 1000% later on. This shift in bone remodeling resulted in an increase in bone volume fraction (BV/TV) by 300% close to the screw and 100% further away. The double effect on bone formation and resorption indicates a great potential of Zoledronateloaded hydrogel for enhancement of peri-implant bone volume which is directly linked to improved implant fixation.

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Section: Discussionmentioning

confidence: 49%

Does locally delivered Zoledronate influence peri-implant bone formation? – Spatio-temporal monitoring of bone remodeling in vivo

Kettenberger

Ston

Thein³

et al. 2014

Biomaterials

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“…Titanium implants were placed in the upper molar socket after one month and the mechanism of osseointegration was investigated. 25) The ultrastructure of the peri-implant epithelium-titanium implant interface was also clarified by using rat maxilla implantation.…”

Section: Introductionmentioning

confidence: 99%

Promotion of Bone Formation around Alendronate-immobilized Screw-Type Titanium Implants after Implantation into Rat Molar Tooth Sockets

Raita

Komatsu

Nifuji

et al. 2014

J. Hard Tissue Biology.

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The aim of this study was to evaluate the effects of alendronate immobilization on bone formation following the implantation of apatite-coated titanium implants in rats. Thin carbonate-containing apatite coatings were deposited onto titanium implants (Ti implants) using a molecular precursor method. Alendronate was then immobilized on apatite-coated titanium implants (HA implants) by immersing the HA implants in alendronate solution (Ald implants). The rat molars were extracted, and the implants were immediately placed in the tooth sockets. Bone labeling was performed 14 and 7 days before sacrifice. At 3 and 9 weeks after implantation, undecalcified sections were prepared and bone histomorphometry was performed. Greater bone mass was found around the Ald implants than around either the Ti or HA implants at both 3 weeks and 9 weeks. At 3 weeks, fluorochrome bone labeling was greater around the Ald implants than around the Ti implants, and the values of bone to implant contact (BIC) and bone mass (BM) were significantly greater around the Ald implants than around the HA and Ti implants. At 9 weeks, bone labeling decreased and the values of BIC and BM increased compared with those at 3 weeks for all types of implant. In conclusion, we found that immobilized alendronate triggered pronounced bone formation around the implants at an early stage of bone healing. These results suggest that alendronate immobilization accelerates implant fixation early in the healing phase.

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“…22,23 In contrast, osseointegration in human bone is achieved 3-4 months after implantation and remodeling takes place over a 1-year period under functional conditions. 1,24 Various implant designs have been used previously to study osseointegration in different experimental in vivo models.…”

mentioning

confidence: 99%

Nanostructured model implants for in vivo studies: influence of well-defined nanotopography on de novo bone formation on titanium implants

Ballo

Agheli²,

Lausmaa³

et al. 2011

IJN

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An implantable model system was developed to investigate the effects of nanoscale surface properties on the osseointegration of titanium implants in rat tibia. Topographical nanostructures with a well-defined shape (semispherical protrusions) and variable size (60 nm, 120 nm and 220 nm) were produced by colloidal lithography on the machined implants. Furthermore, the implants were sputter-coated with titanium to ensure a uniform surface chemical composition. The histological evaluation of bone around the implants at 7 days and 28 days after implantation was performed on the ground sections using optical and scanning electron microscopy. Differences between groups were found mainly in the new bone formation process in the endosteal and marrow bone compartments after 28 days of implantation. Implant surfaces with 60 nm features demonstrated significantly higher bone-implant contact (BIC, 76%) compared with the 120 nm (45%) and control (57%) surfaces. This effect was correlated to the higher density and curvature of the 60 nm protrusions. Within the developed model system, nanoscale protrusions could be applied and systematically varied in size in the presence of microscale background roughness on complex screw-shaped implants. Moreover, the model can be adapted for the systematic variation of surface nanofeature density and chemistry, which opens up new possibilities for in vivo studies of various nanoscale surface-bone interactions.

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Tissue Response to Titanium Implants in the Rat Maxilla: Ultrastructural and Histochemical Observations of the Bone‐Titanium Interface

Abstract: These findings indicate that ossification proceeds at different modes around the titanium implant in rat maxilla, depending on the nature of the recipient bones and the dimension of the gap between the implant and osteotomy margin.

Cited by 113 publications

References 26 publications

Does locally delivered Zoledronate influence peri-implant bone formation? – Spatio-temporal monitoring of bone remodeling in vivo

Does locally delivered Zoledronate influence peri-implant bone formation? – Spatio-temporal monitoring of bone remodeling in vivo

Promotion of Bone Formation around Alendronate-immobilized Screw-Type Titanium Implants after Implantation into Rat Molar Tooth Sockets

Nanostructured model implants for in vivo studies: influence of well-defined nanotopography on de novo bone formation on titanium implants

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