Tissue response to poly‐<scp>L</scp>‐lactide acid‐polyglycolic acid absorbable screws in autogenous bone grafts: a histologic morphological analysis

Matsumoto, Mariza Akemi; Filho, Hugo Nary; Padovan, Luís Eduardo Marques; Kawakami, Roberto Yoshio; Taveira, Luís Antônio de Assis

doi:10.1111/j.1600-0501.2004.01078.x

Cited by 6 publications

(3 citation statements)

References 46 publications

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“…at that time point collagen evoked major irritation in New Zealand White rabbits. Earlier studies have described encapsulated material around PLGA implants as a result of tissue reactions to polymers in bone as well as in subcutaneous pockets [24][25][26] and in rabbit eyes. 27,28 In our study, all the implanted materials had undergone thin capsule formation after 2 weeks.…”

Section: Discussionmentioning

confidence: 99%

Histopathology of the three implanted degradable biopolymers in rabbit eye

Rönkkö

Rekonen

Sihvola

et al. 2008

J Biomedical Materials Res

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New straightforward applications of new biopolymers are needed in glaucoma surgery. The aim of this study was to compare biocompatibility of three biomaterials in rabbit eyes after deep sclerectomy; a collagen implant (AquaFlow) represented the "gold standard". A blend of 85:15 poly(L-lactide-co-glycolide) and 70:30 poly(L-lactide-co-1,3-trimethylene carbonate) copolymers in a molar ratio of 70:30 (Bio-1 = Inion GTR membrane) and poly(DL-lactide-co-glycolide with molar compositions of 50:50 (Bio-2) and 85:15 (Bio-3) were inserted into rabbits eyes. Bio-1, Bio-2 or Bio-3 caused very mild eye irritation or tissue response which was comparable to that of the collagen implant. The biodegradation time of Bio-1, Bio-2, and Bio-3 implants was over one year, 3 months and 6 months, respectively. Implant mapping by Fourier transform infrared (FTIR) microscopy revealed a heterogeneous distribution of degradation products throughout Bio-1, Bio-2, and Bio-3. All implants were surrounded by a very fine tissue capsule which was not visible after total degradation of the implants. The FTIR spectrum of tissue capsule around Bio-1 was almost identical to that around Bio-2 whereas significant differences were observed in the spectrum of the tissue capsule around Bio-3. Despite some differences in tissue response, all tested implants represent biologically acceptable materials for drainage devices in glaucoma surgery.

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Section: Discussionmentioning

confidence: 99%

Histopathology of the three implanted degradable biopolymers in rabbit eye

Rönkkö

Rekonen

Sihvola

et al. 2008

J Biomedical Materials Res

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“…[6][7][8] While some studies did observe an increased inflammatory response and osteoclastic activity, only the full impact of these events on tissue formation may be determined by monitoring complete scaffold degradation. Since bone resorption was observed adjacent to PLAGA absorbable screws at 4 months [9] and PLAGA constructs used in segmental bone defects are likely to contain a greater volume of polymer, long-term polymeric degradation studies are imperative.…”

Section: Introductionmentioning

confidence: 99%

The Implications of Polymer Selection in Regenerative Medicine: A Comparison of Amorphous and Semi‐Crystalline Polymer for Tissue Regeneration

Kofron

Griswold

Kumbar

et al. 2009

Adv Funct Materials

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Biodegradable polymeric scaffolds are being investigated as scaffolding materials for use in regenerative medicine. While the in vivo evaluation of various three‐dimensional (3D), porous, biodegradable polymeric scaffolds has been reported, most studies are ≤3 months in duration, which is typically prior to bulk polymer degradation, a critical event that may initiate an inflammatory response and inhibit tissue formation. Here, a 6 month in vitro degradation and corresponding in vivo studies that characterized scaffold changes during complete degradation of an amorphous, 3D poly(lactide‐co‐glycolide)(3D‐PLAGA) scaffold and near‐complete degradation of a semi‐crystalline3D‐PLAGA scaffold are reported. Using sintered microsphere matrix technology, constructs were fabricated in a tubular shape, with the longitudinal axis void and a median pore size that mimicked the architecture of native bone. Long‐term quantitative measurements of molecular weight, mechanical properties, and porosity provided a basis for theorization of the scaffold degradation process. Following implantation in a critical size ulnar defect model, histological analysis and quantitative microCT indicated early solubilization of the semi‐crystalline polymer created an acidic microenvironment that inhibited mineralized tissue formation. Thus, the use of amorphous over semi‐crystalline PLAGA materials is advocated for applications in regenerative medicine.

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“…These materials arise from two basic sources. Medical devices such as sutures, screws, hemostatic agents, and prosthetic implants can be present in a patient from documented medical procedures (1). Others such as drugs, excipients, and related materials are unexpected (2), and usually require a detailed clinical history to provide insight into potential sources.…”

mentioning

confidence: 99%

Forensic visualization of foreign matter in human tissue by near‐infrared spectral imaging: Methodology and data mining strategies

et al. 2006

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Background:Rapidity of data acquisition, high image fidelity and large field of view are of tremendous value when looking for chemical contaminants or for the proverbial “needle in the haystack” – in this case foreign inclusions in histologic sections of biopsy or autopsy tissues. Near infrared chemical imaging is one of three chemical imaging techniques (NIR, MIR and Raman) based on vibrational spectroscopy, and provides distinct technical advantages for this application.Methods:We have chosen to utilize and evaluate near infrared (NIR) imaging for studies of foreign materials in tissue because the experimental configuration is relatively simple, data collection is rapid, and large sample areas can be screened with high image fidelity and spatial resolution.Results:We have shown that NIR imaging can readily find and identify silicone gel inclusions in biological tissue samples. Additionally, preliminary results indicate that spectral signatures in the data set are also potentially sensitive to structural changes in the surrounding tissue that may be induced by the foreign body.Conclusions:NIR chemical imaging is a powerful, non‐destructive tool for localization and identifying foreign contaminants in biological tissue. Preliminary results indicate that NIR imaging is also sensitive enough to differentiate tissue types (perhaps based on collagen structural differences), and provide data on the spatial localization of these components. © 2006 International Society for Analytical Cytology

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Tissue response to poly‐L‐lactide acid‐polyglycolic acid absorbable screws in autogenous bone grafts: a histologic morphological analysis

Abstract: There are no contraindications of both materials for use as fixation devices in autogenous bone grafts. However, care must be taken when using absorbable screws in a period of 4 months, which can interfere with the sequence of the treatment with endosseous dental implants.

Cited by 6 publications

References 46 publications

Histopathology of the three implanted degradable biopolymers in rabbit eye

Histopathology of the three implanted degradable biopolymers in rabbit eye

The Implications of Polymer Selection in Regenerative Medicine: A Comparison of Amorphous and Semi‐Crystalline Polymer for Tissue Regeneration

Forensic visualization of foreign matter in human tissue by near‐infrared spectral imaging: Methodology and data mining strategies

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