2017
DOI: 10.1002/jbm.b.33835
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Tissue response to five commercially available peritoneal adhesion barriers—A systematic histological evaluation

Abstract: Separating wounded serosa by physical barriers is the only clinically approved adjunct for postoperative adhesion prevention. Since the optimal adhesion barrier has not been found, it is essential to improve our pathogenic understanding of adhesion formation and to compare the effects of different barrier materials on tissue and cells. Wistar rats underwent standardized peritoneal damage and were treated either with Seprafilm, Adept, Intercoat, Spraygel, SupraSeal or remained untreated as a control. 14 days po… Show more

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Cited by 9 publications
(7 citation statements)
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“…Most recently several sprayable/liquid adhesion barriers have been developed. Such sprays are easier to apply, they are adhering and conforming to irregular and complex surfaces [ 10 , 11 ]. An ideal adhesion barrier would be biocompatible, nonimmunogenic, anti-inflammatory, biodegradable, with a degradation rate synchronized with tissue healing, and biomechanically strong for ease of application.…”
Section: Introductionmentioning
confidence: 99%
“…Most recently several sprayable/liquid adhesion barriers have been developed. Such sprays are easier to apply, they are adhering and conforming to irregular and complex surfaces [ 10 , 11 ]. An ideal adhesion barrier would be biocompatible, nonimmunogenic, anti-inflammatory, biodegradable, with a degradation rate synchronized with tissue healing, and biomechanically strong for ease of application.…”
Section: Introductionmentioning
confidence: 99%
“…Although this study tried to compare the five commercially available materials fairly, the limitations of these results are the dose‐dependency and extrapolation to humans from rats. [ 315 ] Further analysis of the biocompatibility of antiadhesion barriers will be expected.…”
Section: Discussionmentioning
confidence: 99%
“…Indeed, our results suggest that the process of cell proliferation and remodeling is not inhibited by the fibrin coating as there was no significant difference in neo-endothelialization. Previous biocompatibility studies have investigated the time course and the spatial distribution of the different cell types within the healing process [ 31 ]. Similar studies are needed for fibrin-based coated stents in order to confirm or disprove our hypothesis.…”
Section: Discussionmentioning
confidence: 99%