Tissue response to five commercially available peritoneal adhesion barriers—A systematic histological evaluation

Schmitt, Volker H.; Mamilos, Andreas; Schmitt, Christine; Neitzer‐Planck, Constanze N. E.; Rajab, Taufiek Konrad; Hollemann, David; Wagner, Willi L.; Krämer, B.; Hierlemann, Helmut; Kirkpatrick, Charles James; Brochhausen, Christoph

doi:10.1002/jbm.b.33835

Cited by 9 publications

(7 citation statements)

References 39 publications

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“…Most recently several sprayable/liquid adhesion barriers have been developed. Such sprays are easier to apply, they are adhering and conforming to irregular and complex surfaces [ 10 , 11 ]. An ideal adhesion barrier would be biocompatible, nonimmunogenic, anti-inflammatory, biodegradable, with a degradation rate synchronized with tissue healing, and biomechanically strong for ease of application.…”

Section: Introductionmentioning

confidence: 99%

Viable cryopreserved umbilical tissue (vCUT) reduces post-operative adhesions in a rabbit abdominal adhesion model

Dhall

Coksaygan

Hoffman

et al. 2019

Bioactive Materials

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Post-operative adhesions, a common complication of surgery, cause pain, impair organ functionality, and often require additional surgical interventions. Control of inflammation, protection of injured tissue, and rapid tissue repair are critical for adhesion prevention. Adhesion barriers are biomaterials used to prevent adhesions by physical separation of opposing injured tissues. Current adhesion barriers have poor anti-inflammatory and tissue regenerative properties. Umbilical cord tissue (UT), a part of the placenta, is inherently soft, conforming, biocompatible, and biodegradable, with antimicrobial, anti-inflammatory, and antifibrotic properties, making it an attractive alternative to currently available adhesion barriers. While use of fresh tissue is preferable, availability and short storage time limit its clinical use. A viable cryopreserved UT (vCUT) “point of care” allograft has recently become available. vCUT retains the extracellular matrix, growth factors, and native viable cells with the added advantage of a long shelf life at −80 °C. In this study, vCUT's anti-adhesion property was evaluated in a rabbit abdominal adhesion model. The cecum was abraded on two opposing sides, and vCUT was sutured to the abdominal wall on the treatment side; whereas the contralateral side of the abdomen served as an internal untreated control. Gross and histological evaluation was performed at 7, 28, and 67 days post-surgery. No adhesions were detectable on the vCUT treated side at all time points. Histological scores for adhesion, inflammation, and fibrosis were lower on the vCUT treated side as compared to the control side. In conclusion, the data supports the use of vCUT as an adhesion barrier in surgical procedures.

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Section: Introductionmentioning

confidence: 99%

Viable cryopreserved umbilical tissue (vCUT) reduces post-operative adhesions in a rabbit abdominal adhesion model

Dhall

Coksaygan

Hoffman

et al. 2019

Bioactive Materials

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“…Although this study tried to compare the five commercially available materials fairly, the limitations of these results are the dose‐dependency and extrapolation to humans from rats. [ 315 ] Further analysis of the biocompatibility of antiadhesion barriers will be expected.…”

Section: Discussionmentioning

confidence: 99%

Advancement of Biomaterial‐Based Postoperative Adhesion Barriers

Chandel

Shimizu

Hasegawa

et al. 2021

Macromolecular Bioscience

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Postoperative peritoneal adhesion (PPA) is a prevalent incidence that generally happens during the healing process of traumatized tissues. It causes multiple severe complications such as intestinal obstruction, chronic abdominal pain, and female infertility. To prevent PPA, several antiadhesion materials and drug delivery systems composed of biomaterials are used clinically, and clinical antiadhesive is one of the important applications nowadays. In addition to several commercially available materials, like film, spray, injectable hydrogel, powder, or solution type have been energetically studied based on natural and synthetic biomaterials such as alginate, hyaluronan, cellulose, starch, chondroitin sulfate, polyethylene glycol, polylactic acid, etc. Moreover, many kinds of animal adhesion models, such as cecum abrasion models and unitary horn models, are developed to evaluate new materials’ efficacy. A new animal adhesion model based on hepatectomy and conventional animal adhesion models is recently developed and a new adhesion barrier by this new model is also developed. In summary, many kinds of materials and animal models are studied; thus, it is quite important to overview this field's current progress. Here, PPA is reviewed in terms of the species of biomaterials and animal models and several problems to be solved to develop better antiadhesion materials in the future are discussed.

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“…Indeed, our results suggest that the process of cell proliferation and remodeling is not inhibited by the fibrin coating as there was no significant difference in neo-endothelialization. Previous biocompatibility studies have investigated the time course and the spatial distribution of the different cell types within the healing process [ 31 ]. Similar studies are needed for fibrin-based coated stents in order to confirm or disprove our hypothesis.…”

Section: Discussionmentioning

confidence: 99%

Vascular Response on a Novel Fibrin-Based Coated Flow Diverter

Mühl-Benninghaus

Fries

Kießling

et al. 2021

Cardiovasc Intervent Radiol

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Purpose Due to thromboembolic complications and in-stent-stenosis after flow diverter (FD) treatment, the long-term use of dual antiplatelet treatment (DAPT) is mandatory. The tested nano-coating has been shown to reduce material thrombogenicity and promote endothelial cell proliferation in vitro. We compared the biocompatibility of coated (Derivo Heal) and non-coated (Derivo bare) FDs with DAPT in an animal model. Methods Derivo® bare (n = 10) and Derivo® Heal (n = 10) FD were implanted in the common carotid arteries (CCAs) of New Zealand white rabbits. One additional FD, alternately a Derivo bare (n = 5) or Derivo Heal (n = 5), was implanted in the abdominal aorta (AA) for assessment of the patency of branch arteries. Histopathological examinations were performed after 28 days. Angiography was performed before and after FD implantation and at follow-up. Results Statistical analysis of the included specimens showed complete endothelialization of all FDs with no significant differences in neointima thickness between Derivo® bare and Derivo® Heal (CCA: p = 0.91; AA: p = 0.59). A significantly reduced number of macrophages in the vessel wall of the Derivo Heal was observed for the CCA (p = 0.02), and significantly reduced fibrin and platelet deposition on the surface of the Derivo Heal was observed for the AA. All branch arteries of the stented aorta remained patent. Conclusion In this animal model, the novel fibrin-based coated FD showed a similar blood and tissue compatibility as the non-coated FD.

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Tissue response to five commercially available peritoneal adhesion barriers—A systematic histological evaluation

Cited by 9 publications

References 39 publications

Viable cryopreserved umbilical tissue (vCUT) reduces post-operative adhesions in a rabbit abdominal adhesion model

Viable cryopreserved umbilical tissue (vCUT) reduces post-operative adhesions in a rabbit abdominal adhesion model

Advancement of Biomaterial‐Based Postoperative Adhesion Barriers

Vascular Response on a Novel Fibrin-Based Coated Flow Diverter

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