Tissue response to commercial silicone and polyurethane elastomers after different sterilization procedures

Zhang, Y Z; Bjursten, Lars Magnus; Freij-Larsson, Christina; Kober, Maria; Wesslén, Bengt

doi:10.1016/0142-9612(96)00055-5

Cited by 70 publications

(39 citation statements)

References 11 publications

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“…This is in accordance with previous studies showing that when both material and surface texture are varied, the surface texture appear to be the predominant factor relative to the induced tissue response [30], [31]. There are several reports indicating that structured and/or porous implant surfaces are favorable as compared with planar ones [29], [34], [40], [44]- [49]. It is conceivable that the different surface structures of the implants elicit different macrophage responses, which in turn may induce different tissue reactions by producing different secretion products such as: chemotactic agents for other cells, growth factors which stimulate the collagen production by the fibroblasts and neutral proteases which may affect the implant surface [50], [51] leading to different foreign-body formation including the thickness of the reactive capsule.…”

Section: A Discussionsupporting

confidence: 91%

Tissue reactions evoked by porous and plane surfaces made out of silicon and titanium

Rosengren

Wallman

Danielsen

et al. 2002

IEEE Trans. Biomed. Eng.

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Tissue reactions evoked by porous and plane surfaces made out of silicon and titanium.Rosengren, Agneta; Wallman, Lars; Danielsen, Nils; Laurell, Thomas; Bjursten, Lars Magnus General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.• Users may download and print one copy of any publication from the public portal for the purpose of private study or research.• You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal Abstract-Square-shaped silicon or titanium implants with plane or porous surfaces surrounded by a rim of silicone were implanted in the rat abdominal wall for evaluation of the tissue response after one, six, or 12 weeks. Cell damage was identified as increased membrane permeability using fluorescence microscopy by injection of propidium iodide prior to the killing of the rats. Capsule thickness and immunohistochemical quantification of macrophages were used as a further measure of the foreign-body reaction. There were no significant differences in capsular cell densities for macrophages, total cells (macrophages, fibroblasts, and other cells), or necrotic cells at the different time points for the four surfaces studied. However, significant differences in the kinetics of the response were found between plane surfaces compared with porous ones. Both types of plane surfaces developed a significant increase in capsule thickness over time in contrast to the porous implants. Porous silicon displayed a significant decrease in total cells in the reactive capsule over time. Furthermore, porous silicon and titanium surfaces displayed a significant decrease in total cell numbers at the implant interface between six and 12 weeks. The present study demonstrated that implanted silicon elicited soft-tissue reactions comparable to that of titanium.

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Section: A Discussionsupporting

confidence: 91%

Tissue reactions evoked by porous and plane surfaces made out of silicon and titanium

Rosengren

Wallman

Danielsen

et al. 2002

IEEE Trans. Biomed. Eng.

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“…Low CD14 secretion was observed on the more moderately hydrophilic siloxane surface. These observations confirm the major effect of the surface chemistry on the inflammatory response of the THP-1 cells [44][45].…”

Section: Thp-1 Cell Adhesion and Inflammatory Responsesupporting

confidence: 81%

A Versatile Gradient of Biomolecules for Regulating Cell Behaviour

2011

Surface and Interfacial Aspects of Cell Adhesion

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“…34 Circular disk specimens (diameter 5 mm, thickness 1 mm) were cut from the polymer films and used as implants. 35 Before insertion the implants were cleaned and sterilized in ethanol, rinsed, and kept in sterile saline until surgery.…”

Section: Implantsmentioning

confidence: 99%

Reactive capsule formation around soft-tissue implants is related to cell necrosis

Rosengren

Danielsen

Bjursten

1999

J. Biomed. Mater. Res.

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Low-density polethylene disks with smooth or course surfaces were implanted in the abdominal wall of rats, and the tissue response was evaluated after 1, 6, or 12 weeks. Cell damage was detected by two different methods. Cells with increased membrane permeability could be identified using fluorescence microscopy by injection of propidium iodide prior to the killing of the rats. Second, cell death was verified by detection of DNA fragmentation. At 1 week a considerable number of the interfacial cells was stained with propidium iodide. Propidium-iodide-positive cells also were enriched at the edges of the disks irrespective of surface texture. The numbers of positive interfacial cells decreased markedly over time. Cells with DNA fragmentation initially displayed a scattered distribution; at later time points they appeared mainly in the outer portion of the enveloping capsule. The reactive capsule was thicker for the smooth surface, and there was a positive correlation between capsule thickness and propidium-iodide-positive cells at earlier implantation periods. The results suggest that the thickness of the reactive capsule is related to the extent of cell necrosis. It is suggested that the major initiator for this cell necrosis is mechanical shear since cell necrosis was found mainly in areas where mechanical shear could be expected.

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Tissue response to commercial silicone and polyurethane elastomers after different sterilization procedures

Cited by 70 publications

References 11 publications

Tissue reactions evoked by porous and plane surfaces made out of silicon and titanium

Tissue reactions evoked by porous and plane surfaces made out of silicon and titanium

A Versatile Gradient of Biomolecules for Regulating Cell Behaviour

Reactive capsule formation around soft-tissue implants is related to cell necrosis

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