Tissue residues due to ronidazole: bioavailability of residues in swine muscle on ingestion by the rat

Wolf, Frank J.; Alvaro, Raul; Steffens, James J.; Wolf, Donald E.; Koniuszy, Frank R.; Green, Marilyn L.; Jacob, Theodore A.

doi:10.1021/jf00124a004

Cited by 8 publications

(1 citation statement)

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“…It should be noted that anaerobic microorganisms of the gut produce metabolites with reduced nitro groups (Koch et al, 1979). However, as these metabolites extensively bind to the solid particles of the gut contents by covalent bonds (Wolf et al, 1984a), their bioavailability is considered to be poor (Wolf et al, 1984b).…”

Section: Pharmacological Mode Of Actionmentioning

confidence: 99%

Pharmaco‐Toxicological Mode of Action of Antimicrobial5‐Nitroimidazole Derivatives

Schmid¹,

Schmid²

1999

Journal of Veterinary Medicine Series A

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5-Nitroimidazole derivatives are used as therapeutic agents against anaerobic microorganisms which are pathogenic to man and animals.The antimicrobial mode of action of these compounds is due to the metabolic reduction of the nitro group by microbial metabolism.By analogy, a reduction of the 5-nitro group in the aerobic animal metabolism is commonly assumed. This assumption is doubtful in its general form, and a more differentiated view is presented.

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Section: Pharmacological Mode Of Actionmentioning

confidence: 99%

Pharmaco‐Toxicological Mode of Action of Antimicrobial5‐Nitroimidazole Derivatives

Schmid¹,

Schmid²

1999

Journal of Veterinary Medicine Series A

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The target animal species in drug toxicity studies: an evaluation of its usefulness and limitations

Roij¹

1986

Comparative Veterinary Pharmacology, Toxicology and Theraphy

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Preliminary studies on the bioavailability and disposition of bioincurred carrot residues of [¹⁴C] linuron and [¹⁴C]3,4‐dichloroaniline in rats

Worobey

Shields

1991

Food Additives and Contaminants

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Carrots grown from seed in soils spiked with [14C = O]linuron or [14C-ring]3,4-dichloroaniline (DCA), were found to contain radioactivity equivalent to 0.73 ppm linuron or 0.60 ppm DCA. After exhaustive extraction with methanol these tubers still retained 35% and 67% of the original 14C-bioincurred residues, for linuron and DCA respectively. To examine the bioavailability of these residues, rats were dosed by gavage (water vehicle) with unextracted tubers and extracted tubers. For comparison purposes 14C-spiked carrot tubers and [14C] standards were also administered. Animals were maintained for 3 days in metabolism cages; urine, faeces, expired gases and several tissues were collected for radioassay. The following relative amounts of radioactivity (expressed as a percentage of the applied dose) were excreted (faeces/urine) for linuron or DCA dosing respectively: unextracted carrots, 28/31, 51/10; extracted carrots, 51/0, 73/3; spiked carrots, 11/43, 63/20; and linuron and DCA standards, 11/46, 26/81. The data demonstrated that approximately 31% and 10% of bioincurred 14C-residues (from linuron and DCA respectively) in unextracted carrot tubers were bioavailable to rats. 14C-Bound residues (extracted tubers) were much less bioavailable (0% and 3% respectively). The disposition of radioactivity in tissues, blood and expired gases was very low (less than or equal to 1.3% per sample) for any dose studied.

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Tissue residues due to ronidazole: bioavailability of residues in swine muscle on ingestion by the rat

Cited by 8 publications

References 0 publications

Pharmaco‐Toxicological Mode of Action of Antimicrobial5‐Nitroimidazole Derivatives

Pharmaco‐Toxicological Mode of Action of Antimicrobial5‐Nitroimidazole Derivatives

The target animal species in drug toxicity studies: an evaluation of its usefulness and limitations

Preliminary studies on the bioavailability and disposition of bioincurred carrot residues of [¹⁴C] linuron and [¹⁴C]3,4‐dichloroaniline in rats

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Tissue residues due to ronidazole: bioavailability of residues in swine muscle on ingestion by the rat

Cited by 8 publications

References 0 publications

Pharmaco‐Toxicological Mode of Action of Antimicrobial5‐Nitroimidazole Derivatives

Pharmaco‐Toxicological Mode of Action of Antimicrobial5‐Nitroimidazole Derivatives

The target animal species in drug toxicity studies: an evaluation of its usefulness and limitations

Preliminary studies on the bioavailability and disposition of bioincurred carrot residues of [14C] linuron and [14C]3,4‐dichloroaniline in rats

Contact Info

Product

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About

Preliminary studies on the bioavailability and disposition of bioincurred carrot residues of [¹⁴C] linuron and [¹⁴C]3,4‐dichloroaniline in rats