Tissue residue studies with ronidazole. Effect of label site on total radioactivity content of rat tissues

Wolf, Frank J.; Alvaro, Raul; Chapin, L. R.; Green, Marilyn L.; Wolf, Donald E.; Koniuszy, Frank R.; Koniuszy, James J.; Jacob, Theodore A.

doi:10.1021/jf00124a003

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Pharmacological Mode Of Action1

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1984

1999

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Cited by 5 publications

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“…It should be noted that anaerobic microorganisms of the gut produce metabolites with reduced nitro groups (Koch et al, 1979). However, as these metabolites extensively bind to the solid particles of the gut contents by covalent bonds (Wolf et al, 1984a), their bioavailability is considered to be poor (Wolf et al, 1984b).…”

Section: Pharmacological Mode Of Actionmentioning

confidence: 99%

Pharmaco‐Toxicological Mode of Action of Antimicrobial5‐Nitroimidazole Derivatives

Schmid¹,

Schmid²

1999

Journal of Veterinary Medicine Series A

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5-Nitroimidazole derivatives are used as therapeutic agents against anaerobic microorganisms which are pathogenic to man and animals.The antimicrobial mode of action of these compounds is due to the metabolic reduction of the nitro group by microbial metabolism.By analogy, a reduction of the 5-nitro group in the aerobic animal metabolism is commonly assumed. This assumption is doubtful in its general form, and a more differentiated view is presented.

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Section: Pharmacological Mode Of Actionmentioning

confidence: 99%