Tissue resident memory T cells in the human conjunctiva and immune signatures in human dry eye disease

Bose, Tanima; Lee, Ryan; Hou, Aihua; Tong, Louis; Chandy, K. George

doi:10.1038/srep45312

Cited by 37 publications

(30 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similar to our previous observation with the homogeneous presence of immune cell types in barrier tissues with a resident memory cell function, our current meta-analysis also attempts to find the quantitative traits of dendritic cells, especially LCs, in the mucosa of the ocular surface, like other mucosal organs (skin, lung, intestine, cervix, gastric mucosa) [6]. The ocular surface immune system has been investigated to have different immune cell components, both in the innate and adaptive branches and the phenotype, though the functions of those components are still under-investigated.…”

Section: Introductionsupporting

confidence: 57%

“…Among the several cells and inflammatory mediators that are important for the ocular surface diseases, we found the number of research papers following this decreasing order: dendritic cells (19) > IL6 (15) > IL17 (8) > CD4 + and CD8 + T cells together (7). The eight diseases that matched the inclusion criteria of the study mentioned in the method section are: contact lens wear [15][16][17][18][19][20], corneal graft rejection [21][22][23], dry eye [6,[24][25][26][27][28][29][30][31][32][33][34], glaucoma [35][36][37][38][39][40][41][42], Graft-vs-host (GvHD) [43,44], keratitis [45][46][47], scleritis [48][49][50], and Sjögren's syndrome [28,29,[32][33][34][51][52][53]. This is a combination of different ocular surface disorders, the range of w...…”

Section: Dendritic Cells Are the Major Immune Cells Responsible For Omentioning

confidence: 97%

“…In addition, societal costs encompassing the loss of productivity are estimated at $11,302 per year, with the overall cost calculated to reach $55.4 billion per year [3]. Since there are only very limited numbers of effective and generalized treatments for this group of diseases, more investigation into its etiology and underlying mechanisms is crucial [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The Innate Immune Cell Profile of the Cornea Predicts the Onset of Ocular Surface Inflammatory Disorders

Palomar

Montolío

Cegoñino

et al. 2019

JCM

Self Cite

View full text Add to dashboard Cite

Ocular surface inflammatory disorder (OSID) is a spectrum of disorders that have features of several etiologies whilst displaying similar phenotypic signs of ocular inflammation. They are complicated disorders with underlying mechanisms related to several autoimmune disorders, such as rheumatoid arthritis (RA), Sjögren’s syndrome, and systemic lupus erythematosus (SLE). Current literature shows the involvement of both innate and adaptive arms of the immune system in ocular surface inflammation. The ocular surface contains distinct components of the immune system in the conjunctiva and the cornea. The normal conjunctiva epithelium and sub-epithelial stroma contains resident immune cells, such as T cells, B cells (adaptive), dendritic cells, and macrophages (innate). The relative sterile environment of the cornea is achieved by the tolerogenic properties of dendritic cells in the conjunctiva, the presence of regulatory lymphocytes, and the existence of soluble immunosuppressive factors, such as the transforming growth factor (TGF)-β and macrophage migration inhibitory factors. With the presence of both innate and adaptive immune system components, it is intriguing to investigate the most important leukocyte population in the ocular surface, which is involved in immune surveillance. Our meta-analysis investigates into this with a focus on both infectious (contact lens wear, corneal graft rejection, Cytomegalovirus, keratitis, scleritis, ocular surgery) and non-infectious (dry eye disease, glaucoma, graft-vs-host disease, Sjögren’s syndrome) situations. We have found the predominance of dendritic cells in ocular surface diseases, along with the Th-related cytokines. Our goal is to improve the knowledge of immune cells in OSID and to open new dimensions in the field. The purpose of this study is not to limit ourselves in the ocular system, but to investigate the importance of dendritic cells in the disorders of other mucosal organs (e.g., lungs, gut, uterus). Holistically, we want to investigate if this is a common trend in the initiation of any disease related to the mucosal organs and find a unified therapeutic approach. In addition, we want to show the power of computational approaches to foster a collaboration between computational and biological science.

show abstract

Section: Introductionsupporting

confidence: 57%

Section: Dendritic Cells Are the Major Immune Cells Responsible For Omentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The Innate Immune Cell Profile of the Cornea Predicts the Onset of Ocular Surface Inflammatory Disorders

Palomar

Montolío

Cegoñino

et al. 2019

JCM

Self Cite

View full text Add to dashboard Cite

show abstract

“…The percentage of the population is marked as red below the name of each of the populations. The total percentage of the population is 98%, because CD4 + T EMRA population was not included in the mentioned scatterplot (modified from Bose et al 21 ). Please click here to view a larger version of this figure.…”

Section: Representative Resultsmentioning

confidence: 99%

A Non-invasive Way to Isolate and Phenotype Cells from the Conjunctiva

Bose

Hou

Lee

et al. 2017

JoVE

Self Cite

View full text Add to dashboard Cite

Traditionally, ocular surface cytology is studied with techniques such as spatula technology and brush technology. The problem with these techniques is that they may induce traumatic lesions on the surface of the eye, which can progress to scarring, eyelid deformity, limbal stem cell deficiency and in some cases, cause great discomfort to the subject. To avoid these clinical problems, impression cytology (IC) was developed to diagnose dry eye disease and later neoplasia, atopic disease, vernal keratoconjunctivitis and keratoconjunctivitis sicca. Typically, clinicians manually cut filter papers into required shapes and apply these to the ocular surface. Here, we describe how to perform IC using a commercially available medical device. This technique is explained here followed by immunophenotyping by flow cytometry. This technique requires less manual handling and causes less injury to the ocular surface.

show abstract

“…The involvement of both innate and adaptive immune system pathways in DED is well documented ( 6 , 7 ). Several cytokine molecules are identified to regulate or to trigger these pathways.…”

Section: Introductionmentioning

confidence: 99%

Cluster Analysis of Dry Eye Disease Models Based on Immune Cell Parameters – New Insight Into Therapeutic Perspective

2020

Self Cite

View full text Add to dashboard Cite

Dry eye disease (DED) can be represented as a display of disease in the mucosal part of the eye. It is quite distinct from the retinal side of the eye which connects with the neurons and thus represents the neuroimmunological disease. DED can occur either by the internal damage of the T cells inside the body or by microbial infections. Here we summarize the most common animal model systems used for DED relating to immune factors. We aimed to identify the most important immune cell/cytokine among the animal models of the disease. We also show the essential immune factors which are being tested for DED treatment. In our results, both the mechanism and the treatment of its animal models indicate the involvement of Th1 cells and the pro-inflammatory cytokine (IL-1β and TNF-α) related to the Th1-cells. The study is intended to increase the knowledge of the animal models in the field of the ocular surface along with the opening of a dimension of thoughts while designing a new animal model or treatment paradigm for ocular surface inflammatory disorders.

show abstract

Tissue resident memory T cells in the human conjunctiva and immune signatures in human dry eye disease

Cited by 37 publications

References 51 publications

The Innate Immune Cell Profile of the Cornea Predicts the Onset of Ocular Surface Inflammatory Disorders

The Innate Immune Cell Profile of the Cornea Predicts the Onset of Ocular Surface Inflammatory Disorders

A Non-invasive Way to Isolate and Phenotype Cells from the Conjunctiva

Cluster Analysis of Dry Eye Disease Models Based on Immune Cell Parameters – New Insight Into Therapeutic Perspective

Contact Info

Product

Resources

About