Tissue repair in presence of locally applied inhibitors of fibrinolysis

Fibrin degradation and angiogenesis: Quantitative analysis of the angiogenic response in the chick chorioallantoic membrane

“…It is also of interest to note that during advanced organization of blood clot, the fibrinolytic activity present is largely associated with growing capillary endothelium, which also secretes plasminogen activator, rather than inflammatory cells. 23 No truly quantitative method for assessing the stimulation of in vivo angiogenesis has been described. Using the CAM, simple scoring methods have generally been employed, and using the rabbit eye model the rate of growth of vessels from the edge of the cornea towards a central stimulus has been measured,28 but these and other methods are regarded as at best ~emiquantitative.~~ Vascular proliferation is accompanied by cell division2 and this was the rationale for development of the new assay system.…”

Plasminogen activator in the normal gingiva of the dog

“…The roie of fibrinolysis in regulating connective tissue repair has been studied by implanting homologous fibrin clots in rat tissue, Histochemical methods showed fibrinolytic activity continuing for weeks around these implants (Kwaan & Astrup 1964), More recently, these same authors studied the effect of locally applied inhibitors of fibrinolysis in tissue repair. They demonstrated that inhibitors of fibrinol}'sis causes the fibrin matrix to be retained for prolonged periods of time leading to early fibroblastic proliferation and extensive fibrosis (Kwaan & Astrup 1969),…”

The Role of Fibrinolysis in Disease Processes

“…In the experimental study in which the fibrino lytic activity in the wound was inhibited by incor poration of epsilon-aminocaproic acid (EACA) or by a protease inhibitor, it was found that the delay in fibrin removal from the wound resulted in an enhanced formation of connective tissue with an in crease in collagen and tensile strength of the wound tissue. 58 Increased fibrosis of lung, characteristic of bovine high mountain disease (brisket disease), is attributed to the presence of excessive protease inhibitors in bovine lung tissues caused by low atmospheric pressure. 9 Astrup and Brakman 8 hypo thesized that impaired fibrinolysis was responsible for the fibrosis of hemarthrotic joints in hemo philia, the physiologic obliteration of the ductus arteriosus after birth, 31 the poor healing of cutane ous lesions in cutaneous and systemic vasculitis, 91 and other skin injuries.…”