Tissue remodelling and increased DNA damage in patients with incompetent valves in chronic venous insufficiency

Ortega, Miguel Á.; Fraile-Martínez, Óscar; García-Montero, Cielo; Pekarek, Leonel; Álvarez-Mon, Miguel Ángel; Guijarro, Luis G.; Boyano, Maria Del Carmen; Sáinz, Felipe; Álvarez‐Mon, Melchor; Buján, Julia; García‐Honduvilla, Natalio; Asúnsolo, Ángel

doi:10.1111/jcmm.16711

Cited by 5 publications

(5 citation statements)

References 62 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Besides, there are some differences in younger patients (<50 years old) with venous reflux in comparison to those without venous reflux and elder patients with and without venous reflux. Our results are in agreement with previous studies in which young patients with venous reflux exhibited different molecular and tissue markers in comparison to older patients and those without venous reflux [13,15,[21][22][23].…”

Section: Discussionsupporting

confidence: 93%

“…More interestingly, when we compare the total number of fibers in the venous wall according to the age, we observe that young patients with reflux show a significant increase in the elastic fibers and its diameter. These differences are in agreement to previous results observing that young patients with venous reflux exhibit an enhanced tissue remodeling, with a distinct pattern of matrix metalloproteases (MMP) activity and their endogenous tissue inhibitors of MMP (TIMPs) [13]. The enhanced elastic content in the vascular wall of young patients with reflux could indicate the need for greater dynamism in the environment of these areas of the venous wall.…”

Section: Discussionsupporting

confidence: 91%

“…The exam included the great saphenous axis from the inguinal region to the femoral ankle and vein. The saphenous vein and popliteal vein were also evaluated in the standing position, with the patient facing away from the examiner and with the leg unloaded, as described by Ortega et al [13]. All patients were classified as CEAP C1 or higher (Table 1).…”

Section: Diagnosismentioning

confidence: 99%

See 2 more Smart Citations

Contribution of the Elastic Component and Venous Wall Arterialization in Patients with Venous Reflux

Ortega

Fraile-Martínez

García-Montero

et al. 2022

JPM

Self Cite

View full text Add to dashboard Cite

Chronic venous disease (CVeD) is defined as a set of disorders affecting the venous system mainly manifested in the form of varicose veins. CVeD is characterized by a sustained venous hypertension, leading to a plethora of functional and structural changes in the vein that may cause valve incompetence and pathologic reflux. In turn, venous reflux aggravates the venous hypertension and enhances the progression of CVeD into the most advanced stages. Previous studies have proposed that there are several alterations in the venous wall preceding the valve dysfunction and venous reflux. Besides, it has also been identified that young patients with CVeD present premature aging and changes in the venous wall composition that may be related to the presence of venous reflux. In this context, the aim of the present study is to examine the possible pathophysiological role of elastic fibers and their precursors in the venous wall of patients with reflux in comparison to those without reflux, considering the variable age in both groups (<50 years and ≥50 years). We performed immunohistochemical and quantitative polymerase chain reaction (PCR) in order to assess the protein and gene expression of tropoelastin, fibrillin-1, fibulins 4 and 5, lysyl oxidase and lysyl oxidase like 1, respectively. In parallel, we assessed the elastin content through histological techniques (orcein stain) in this group of patients. Our results show significant changes in elastic fibers and their precursors in young patients with pathologic reflux when compared with elder patients with reflux and young patients without reflux. These variations suggest that the venous system of young patients with venous reflux appears to present an enhanced dynamism and arterialization of the venous wall, which may be associated with a premature aging and pathological environment of the tissue.

show abstract

Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 91%

Section: Diagnosismentioning

confidence: 99%

See 1 more Smart Citation

Contribution of the Elastic Component and Venous Wall Arterialization in Patients with Venous Reflux

Ortega

Fraile-Martínez

García-Montero

et al. 2022

JPM

Self Cite

View full text Add to dashboard Cite

show abstract

“…Several studies have shown how proteins that are related to the MAPK pathway are expressed in vascular structures in the adventitial tunica, which could be explained by the damage that is caused by factors such as mechanical pressure. 30,37,40,41…”

Section: Discussionmentioning

confidence: 99%

Chronic venous disease patients show increased IRS-4 expression in the great saphenous vein wall

et al. 2021

Self Cite

View full text Add to dashboard Cite

Objectives Chronic venous disease (CVeD) is a multifactorial and debilitating condition that has a high prevalence in Western countries and an important associated socioeconomic burden. Varicose veins (VVs) are the most common manifestations of CVeD. Pathologically, many morphological and functional changes have been described in VVs, which most notably affect venous wall integrity. Previous studies have found several molecular alterations that negatively affect normal cell signaling pathways. Insulin receptor substrate (IRS)-4 is a central adaptor protein that is closely related to insulin/insulin-like growth factor-1 signaling upstream, phosphatidylinositol 3-kinase/Akt or mitogen-activated protein kinases downstream, and other proteins. These molecular pathways have been implicated in CVeD pathogenesis. Thus, the aim of our study was to identify the role of IRS-4 in VV tissue. Methods We conducted a histopathological study to analyze IRS-4 protein expression in CVeD patients compared with healthy controls. Results Our results demonstrate a significant increase in IRS-4 expression in VV tissue. Conclusions IRS-4 may be implicated in CVeD development and progression. Therefore, IRS-4 could be a potential diagnostic or therapeutic target for patients with this condition.

show abstract

“…Compression stockings, foam sclerotherapy, radiofrequency ablation, and endovenous laser therapy are available for managing VV [3][4][5][6][7][8][9][10]. However, the gold standard treatment of VV still is surgical flush ligation of the great saphenous vein and stripping incompetent veins with perforator ligation [11,12].…”

Section: Introductionmentioning

confidence: 99%

Effect of Trendelenburg’s Operation With Subfascial Ligation of Perforators in Clinical Improvement and Quality of Life Among Patients With Varicose Veins

Vemulakonda¹,

Kumbhar²,

Prakash³

et al. 2023

Cureus

View full text Add to dashboard Cite

BackgroundAssessing patients' quality of life has received increasing attention, mainly because questions have been raised regarding the direct benefits of the treatment provided. Hence, clinical outcomes and quality of life must be measured after chronic venous disease treatment. The primary objective of the study was to assess the improvement in clinical outcome and improvement in quality of life using the revised venous clinical severity score and chronic venous insufficiency questionnaire-14, respectively, in patients with varicose veins undergoing Trendelenburg's surgery and subfascial ligation of perforators. The secondary objective was to identify the relationship between the revised venous clinical severity score and the chronic venous insufficiency questionnaire-14 score. MethodThe present study is a single-center, prospective cohort study to assess the clinical improvement and quality of life in patients with varicose veins undergoing Trendelenburg surgery and subfascial ligation of perforators. All the study participants were evaluated preoperatively with the clinical, etiological, anatomical, and pathophysiological stage of the disease, revised venous clinical severity score for the clinical severity, and the chronic venous insufficiency questionnaire-14 questionnaire for the quality of life. The study participants were reviewed 90 days after surgery and reassessed for clinical severity and quality of life, both scores.

show abstract

Tissue remodelling and increased DNA damage in patients with incompetent valves in chronic venous insufficiency

Cited by 5 publications

References 62 publications

Contribution of the Elastic Component and Venous Wall Arterialization in Patients with Venous Reflux

Contribution of the Elastic Component and Venous Wall Arterialization in Patients with Venous Reflux

Chronic venous disease patients show increased IRS-4 expression in the great saphenous vein wall

Effect of Trendelenburg’s Operation With Subfascial Ligation of Perforators in Clinical Improvement and Quality of Life Among Patients With Varicose Veins

Contact Info

Product

Resources

About