Tissue Reactions of 5 Sling Materials and Tissue Material Detachment Strength of 4 Synthetic Mesh Materials in a Rabbit Model

Yıldırım, Asıf; Başok, Erem Kaan; Gulpinar, T.; Gürbüz, Cenk; Zemherı, Ebru; Tokuç, Reşit

doi:10.1097/01.ju.0000176478.17749.07

Cited by 42 publications

(31 citation statements)

References 11 publications

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“…Yildirim et al . also observed marked inflammation on the early days after implantation and predominant fibrotic reaction on days 15 and 3023. Similarly, another study reported an early increase in IL-1 with peak during first week and reduced after 15 days with a sharp increase in MMP-2 around day 7 and declines thereafter24.…”

Section: Discussionmentioning

confidence: 62%

The immunohistochemical and urodynamic evaluation towards the collagen-coated and non-coated polypropylene meshes implanted in the pelvic wall of the rats

Lin

Yusoff

et al. 2016

Sci Rep

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Our aim is to study the inflammatory response towards the collagen-coated and non-coated polypropylene meshes in rats and the urodynamic investigation post-operatively. Forty-two female Sprague Dawley were divided into 7 groups of 6 rats; Control, Day 7 and 30 for Sham, Avaulta Plus (MPC), Perigee (MP). UDS were taken at days 7 and 30. Mesh with the vagina and bladder wall was removed and sent for immunohistochemical examination. Results showed intense inflammatory reaction on day 7 in the study groups which decreased on day 30. IL-1, TNF-α, MMP-2 and CD31 were observed to decrease from day 7 to day 30. NGF was almost normal on day 30 in all groups. UDS showed no difference in voiding pressure. Both Study and Sham groups had shorter voiding interval (VI) on day 7 but significantly lower in MPC. VI had significantly increased on day 30 in all groups. Voided volume was significantly lower in the mesh groups even when an increase was seen on day 30. In conclusion, the higher levels of IL-1, TNF-α and MMP-2 in collagen-coated polypropylene mesh imply greater inflammation than the non-coated polypropylene mesh. Mesh implantation can lead to shorter voiding interval and smaller bladder capacity.

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Section: Discussionmentioning

confidence: 62%

The immunohistochemical and urodynamic evaluation towards the collagen-coated and non-coated polypropylene meshes implanted in the pelvic wall of the rats

Lin

Yusoff

et al. 2016

Sci Rep

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“…Tissue reactions to different types of synthetic materials used to repair the defects of the pelvic floor are almost established and have not been dealt with in this study (22)(23)(24)(25). It is known that, apart from the mechanical properties of the implanted material, local factors such as tissue tropism, infections and the surgical technique are directly related to the rates of extrusion (26,27).…”

Section: Discussionmentioning

confidence: 99%

Primary fixation of mini slings: a comparative biomechanical study in vivo

Palma

Siniscalchi²,

Maciel³

et al. 2012

Int. braz j urol.

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“…The recently published data indicate that the composition of the fibers, type of weave, pore size, tensile strength, flexibility of the material, and tissue response of sling materials may play a role in surgical success [23][24][25] . In an earlier animal study performed at our center, the mesh-to-tissue attachment strength of the IVS was found to be the least among different types of sling mesh materials [26] .…”

Section: Discussionmentioning

confidence: 99%

Cadaveric Fascia Lata versus Intravaginal Slingplasty for the Pubovaginal Sling: Surgical Outcome, Overall Success and Patient Satisfaction Rates

Başok

Yıldırım²,

Atsu³

et al. 2008

Urol Int

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Background: A wide variety of surgical procedures has been used to treat female stress urinary incontinence (SUI). The purpose of this study was to compare cadaveric fascia lata (CFL) sling with intravaginal slingplasty (IVS) in the surgical treatment of SUI. Methods: One hundred and thirty-nine women with SUI were randomly assigned to either CFL sling (n = 67) or IVS (n = 72). Concomitant urinary urge incontinence was present in 49 patients (73%) in the CFL sling and 44 patients (61%) in the IVS group. Daily mean pad usage was 4.1 ± 3.5 in the CFL sling and 2.9 ± 1.7 in the IVS group. The objective cure rate was evaluated by the pad test, and patient satisfaction rate was assessed by a subjective questionnaire. Results: The surgical results of both procedures with a follow-up 12 months were documented. The overall success rate was 79% in the CFL sling and 70.8% in the IVS (p = 0.261). In contrast patient satisfaction rates were 82 and 87.5%, respectively (p = 0.210). Comparison of the CFL sling with IVS showed persistent urinary urge incontinence in 67 and 25% (p = 0.0001) and de novo urinary urge incontinence in 22 and 6.9%, respectively (p = 0.009). The groups did not differ significantly with respect to intraoperative and postoperative complications. Conclusions: There is no statistical difference in the overall success, satisfaction and complication rates in either group. In our series, both procedures were found to be effective, durable and significantly improved quality of life in patients with SUI but long-term results are awaited.

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Tissue Reactions of 5 Sling Materials and Tissue Material Detachment Strength of 4 Synthetic Mesh Materials in a Rabbit Model

Cited by 42 publications

References 11 publications

The immunohistochemical and urodynamic evaluation towards the collagen-coated and non-coated polypropylene meshes implanted in the pelvic wall of the rats

The immunohistochemical and urodynamic evaluation towards the collagen-coated and non-coated polypropylene meshes implanted in the pelvic wall of the rats

Primary fixation of mini slings: a comparative biomechanical study in vivo

Cadaveric Fascia Lata versus Intravaginal Slingplasty for the Pubovaginal Sling: Surgical Outcome, Overall Success and Patient Satisfaction Rates

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