Tissue reactions after subcutaneous and intraosseous implantation of iRoot SP, MTA and AH Plus

Zhang, Wei; Peng, Bin

doi:10.4012/dmj.2014-271

Cited by 52 publications

(66 citation statements)

References 28 publications

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“…Therefore, the reaction of bone to a biomaterial allows one to evaluate its biocompatibility. Thus, we have preferred to test the osseous reaction to our materials using the tibias of Wistar rats in a similar manner as reported in the endodontic literature [ 3 , 7 , 13 , 22 , 23 ]. Also in these studies, one can see that the study periods vary from author to author and there are no standart time points.…”

Section: Discussionmentioning

confidence: 99%

“…Periapical surgery is commonly comprised of root-end resection, apical cavitation, and root-end filling to seal the communication between the periapical tissues and the root canal system [ 1 ]. An “ideal” root-end filling material should have properties like; easy handling, good biocompatibility and apical sealability at the root apex to prevent the egress of bacteria, and bacterial byproducts [ 2 , 3 ]. It should also be insoluble in body fluids such as blood, saliva, and tissue fluid [ 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

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Effect of the plant-based hemostatic agent Ankaferd Blood Stopper® on the biocompatibility of mineral trioxide aggregate

et al. 2016

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BackgroundDue to the detrimental effect of blood contamination on the physico-chemical properties of mineral trioxide aggregate (MTA), obtaining an effective hemostasis in the surgical crypt during apical surgery is of paramount importance. The purpose of this in vivo study was to analyze the effect of Ankaferd Blood Stopper® (ABS) contamination on the biocompatibility of MTA.MethodsForty of 56 Wistar–Albino rats were divided randomly and equally into two groups (MTA and MTA-ABS) according to whether or not a hemostatic agent was used. The remaining 16 rats were designated as the control group. Rats in the experimental groups received freshly mixed MTA-Angelus in polyethylene tubes, which were inserted into monocortical bore holes created in their tibias. In the MTA-ABS group only, 0.5 mL of ABS solution was administered topically on the defect sites followed by implantation of MTA tubes. Inflammation, foreign-body reaction (FBR), necrosis, fibrosis, and new bone formation (NBF) were studied 7, 30, 60, and 90 days after implantation.ResultsOn day7, statistically significant differences were found in tissue reactions with regard to NBF and necrosis (p = 0.044 and p = 0.024, respectively), the latter being observed in 40 % of the samples only in the MTA-ABS group. Slight inflammation in all groups was confined to day-7 only. Mild necrosis was present in the MTA-ABS group only on day-7. Severity of the foreign body reaction and fibrosis was limited. New bone formation increased gradually over time in all groups, reaching a maximum on day-90.ConclusionsMTA and ABS-contaminated MTA are equally biocompatible. ABS does not impair the properties of MTA.Electronic supplementary materialThe online version of this article (doi:10.1186/s12903-016-0302-0) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of the plant-based hemostatic agent Ankaferd Blood Stopper® on the biocompatibility of mineral trioxide aggregate

et al. 2016

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“…BC Sealer has moderate cytotoxic effects on osteoblasts at five weeks [119] but another study showed that iRoot SP and MTA induced differentiation of dental papilla stem cells to odontoblast-like cells and induced biomineralziation [122]. No difference in inflammatory response to intraosseous and subcutaneous placement of iRoot SP and MTA was noted in rats and both of these materials showed biocompatibility [123].…”

Section: Bc Sealer and Iroot Spmentioning

confidence: 99%

A Review of Endodontic Bioceramics

Assadian¹,

Moghaddam²,

Amini³

et al. 2016

J Islam Dent Assoc Iran

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Background and Aim: The use of ceramics has a long history. A new category of these materials was used in medicine in 1960 introduced as bioceramics. Biocompatibility, osteoinductivity and sealing ability are among the most favorable characteristics of endodontic bioceramics. Introduction of mineral trioxide aggregate (MTA) revolutionized endodontics and this new era is progressively growing. Materials and Methods: This article reviews endodontic bioceramic materials in the Iranian market such as different types of MTA (ProRoot, Angelus, Root MTA), calcium enriched mixture (CEM) cement, Endo Sequence, iRoot products and MTA Fill apex sealer. Electronic search was carried out for the existing literature in PubMed, Medline and Google Scholar from July 1995 to January 2016 and more clinically applicable data were collected. Conclusion: Favorable characteristics and promising results of bioceramics make them suitable for use in endodontics and new products of this generation are increasingly introduced to the dental market.

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“…TotalFill BC (FKG, Dentaire, La Chaux-de-Fonds, Switzerland; marketed as EndoSequence BC from Brasseler USA in North America) is a newer calcium silicate-based cement that was developed to overcome the disadvantages of MTA. It is a biocompatible [19] premixed cement that sets in the presence of water and has shorter setting time than MTA [16]. It is also reported that BC is a bioactive cement [20] with similar compressive strength to MTA [21].…”

Section: Introductionmentioning

confidence: 99%

The effect of intracanal medicaments used in Endodontics on the dislocation resistance of two calcium silicate-based filling materials

Alsubait

Alsaad²,

Alahmari

et al. 2020

BMC Oral Health

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Background: Intracanal medicaments can be used in various endodontic conditions including multiple visit endodontics after trauma or in regenerative endodontics. These medicaments should be removed from the root canal before the placement of the filling or repair material. The aim of the present study was to evaluate the effect of prior calcium hydroxide (Ca(OH) 2 ) and modified triple antibiotic paste (mTAP) placement on the push-out bond strength of TotalFill BC fast set putty (BC fast set putty) to root dentin when compared to mineral trioxide aggregate (MTA). Methods: The root canals of 45 extracted mandibular premolars were prepared to a standardized internal diameter (1.5 mm). The specimens were randomly assigned to 3 groups according to the intracanal medicament used: mTAP (a mixture of metronidazole, ciprofloxacin, and cefaclor), Ca(OH) 2 , and no intracanal medicament. After 1 week, the medicaments were removed, and the middle third of the roots were cut into two transverse sections (2.0 ± 0.05) (n = 90 slices). Thereafter, the specimens were divided into two subgroups (n = 45 each): MTA or BC putty. After 1 week, the push-out test was performed and failure mode was evaluated. The data were statistically analyzed using two-way ANOVA and Tukey's post hoc. Results: The application of the intracanal medicament did not significantly affect the bond strength of BC putty (p > .05). For MTA, the prior application of Ca(OH) 2 or mTAP significantly decreased the dislocation resistance (p < .05). Specimens in the MTA subgroups showed an almost equal number of cohesive and mixed types of failure while the majority of the specimens in the BC putty subgroups revealed the cohesive type. Conclusions: Ca(OH) 2 and mTAP promoted lower bond strength of MTA to root dentin compared to the control group. However, the BC fast set putty bond strength to dentin was not affected by prior medication with Ca(OH) 2 or mTAP.

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Tissue reactions after subcutaneous and intraosseous implantation of iRoot SP, MTA and AH Plus

Cited by 52 publications

References 28 publications

Effect of the plant-based hemostatic agent Ankaferd Blood Stopper® on the biocompatibility of mineral trioxide aggregate

Effect of the plant-based hemostatic agent Ankaferd Blood Stopper® on the biocompatibility of mineral trioxide aggregate

A Review of Endodontic Bioceramics

The effect of intracanal medicaments used in Endodontics on the dislocation resistance of two calcium silicate-based filling materials

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