Tissue reactions after homoplastic and heteroplastic transplantation of eyes in the anuran amphibla

Schwind, Joseph L.

doi:10.1002/jez.1400770105

Cited by 10 publications

(4 citation statements)

References 23 publications

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“…2,[11][12][13][14][15][16][17][18][19][20][21][22][23] The remaining 19 utilized cold-blooded species. [3][4][5][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39] After data extraction, a total of 1998 eyes were included, 1831 of which belonged to nonmammalian organisms and 167 to mammals, including 13 human cadavers and two living humans.…”

Section: Resultsmentioning

confidence: 99%

“…2,11–23 The remaining 19 utilized cold-blooded species. 3–5,24–39 After data extraction, a total of 1998 eyes were included, 1831 of which belonged to nonmammalian organisms and 167 to mammals, including 13 human cadavers and two living humans.…”

Section: Resultsmentioning

confidence: 99%

“…46 In cold-blooded species, the RGCs and ON have innate regenerative properties owing to their strong growth-stimulating capacities and intrinsic retinal astrocyte growth-inducing factors. 47 In these species, researchers opted to merely approximate donor and recipient ONs, [2][3][4][26][27][28][29][30][31][32][33][34][35][36] and vision restoration was found in over 50% of transplanted organisms. 2,27,28,[37][38][39][40] This is in stark contrast with mammalian models, which have yet to report vision perception after WET, even when a retinal response to light was detected and eye perfusion was maintained.…”

Section: Ocular Functionality and The Nervous Systemmentioning

confidence: 99%

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Technical Feasibility of Whole-eye Vascular Composite Allotransplantation: A Systematic Review

Laspro

Chaya

Brydges

et al. 2023

Plastic and Reconstructive Surgery - Global Open

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Background: There are over 43 million individuals in the world who are blind. As retinal ganglion cells are incapable of regeneration, treatment modalities for this condition are limited. Since first incepted in 1885, whole-eye transplantation (WET) has been proposed as the ultimate cure for blindness. As the field evolves, different aspects of the surgery have been individually explored, including allograft viability, retinal survival, and optic nerve regeneration. Due to the paucity in the WET literature, we aimed to systematically review proposed WET surgical techniques to assess surgical feasibility. Additionally, we hope to identify barriers to future clinical application and potential ethical concerns that could be raised with surgery. Methods: We conducted a systematic review of PubMed, Embase, Cochrane Library, and Scopus from inception to June 10, 2022, to identify articles pertaining to WET. Data collection included model organisms studied, surgical techniques utilized, and postoperative functional outcomes. Results: Our results yielded 33 articles, including 14 mammalian and 19 cold-blooded models. In studies performing microvascular anastomosis in mammals, 96% of allografts survived after surgery. With nervous coaptation, 82.9% of retinas had positive electroretinogram signals after surgery, indicating functional retinal cells after transplantation. Results on optic nerve function were inconclusive. Ocular-motor functionality was rarely addressed. Conclusions: Regarding allograft survival, WET appears feasible with no complications to the recipient recorded in previous literature. Functional restoration is potentially achievable with a demonstrated positive retinal survival in live models. Nevertheless, the potential of optic nerve regeneration remains undetermined.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Ocular Functionality and The Nervous Systemmentioning

confidence: 99%

See 1 more Smart Citation

Technical Feasibility of Whole-eye Vascular Composite Allotransplantation: A Systematic Review

Laspro

Chaya

Brydges

et al. 2023

Plastic and Reconstructive Surgery - Global Open

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show abstract

“…Humm et al (1957) have transplanted melanomas from adult platyfish-swordtail hybrids to embryos of both species and their hybrids. A close correlation has been noted between the time of parturition in mammals (e.g., Freund, 1930), hatching in birds (e.g., Murphy, 1914;Waterman, 1936) or metamorphosis in amphibians (Schwind, 1933(Schwind, , 1937Triplett, 1958) and the development of the ability to react immunologically to implanted or injected foreign materials. This difference in results could be explained in one or both of two ways.…”

Section: Discussionmentioning

confidence: 93%

Tissue Specificity in Embryonic and Adult Cymatogaster Aggregata Studied by Scale Transplantation

Triplett

Barrymore

1960

The Biological Bulletin

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An incompatibility manifested in heteroplastic parabiosis or grafting in Amblystoma due to a toxin of cutaneous origin

Humphrey

Burns

1939

J. Exp. Zool.

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Tissue reactions after homoplastic and heteroplastic transplantation of eyes in the anuran amphibla

Cited by 10 publications

References 23 publications

Technical Feasibility of Whole-eye Vascular Composite Allotransplantation: A Systematic Review

Technical Feasibility of Whole-eye Vascular Composite Allotransplantation: A Systematic Review

Tissue Specificity in Embryonic and Adult Cymatogaster Aggregata Studied by Scale Transplantation

An incompatibility manifested in heteroplastic parabiosis or grafting in Amblystoma due to a toxin of cutaneous origin

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