Tissue reaction to three subcutaneously implanted local hemostatic agents

Evaluation of antibiotic releasing porous polymethylmethacrylate space maintainers in an infected composite tissue defect model

“…Although gelatin cannot be excluded as a cause of dehiscence, it is perhaps a less likely culprit as previous studies have not shown dehiscence when gelatin is implanted in the oral and maxillofacial region, though these studies are not extensive. [23,24] Previous studies have shown that antibiotics, while intended to target bacteria, can have detrimental effects on viability and function of host cells in vitro. [25,26] This toxic effect seen in vitro could lead to breakdown of the soft tissue, fenestration, and dehiscence in vivo.…”

Oxidized cellulose: an unusual cause of post hysterectomy hemorrhage

“…If left in situ degradation is expected to commence within 24-48 h and will be surrounded by inflammatory granulation tissue at day 7; complete degradation usually occur between 4 and 8 weeks. 6,7 Therefore patients with oxidized cellulose placed during surgery may present postoperatively with the haemostatic material still present. This is a rare case of a local tissue reaction to oxidized cellulose mimicking pelvic sepsis.…”

“…9 It is important to document in notes when oxidized cellulose is used despite typical radiological appearances being reported. 7 Some guidelines recommend using it sparingly where its use is indispensible, as many such cases have been attributed to use in excess. 8 The Society of Obstetricians and Gynaecologists of Canada recommends using oxidized cellulose for patients who are at high risk of forming clinically significant adhesions.…”

Oxidized cellulose (Surgicel) based reaction post thyroidectomy mimicking an abscess: A case report

“…If left in situ degradation is expected to commence within 24-48 h and will be surrounded by inflammatory granulation tissue at day 7; complete degradation will usually occur between 4 and 8 weeks. 4,5 Surgicel has been reported as mimicking pseudocancer; abscess formation and granuloma. [2][3][4][5][6][7][8][9][10][11][12] The majority can be described by cell mediated type 4 delayed hypersensitivity and peritoneal histiocytic reactions.…”

“…10,11 The bulk of these cases presented with pain or on routine follow up imaging between 6 and 52 weeks. [2][3][4][5][6][7][8][9][10][11][12] The reported case is the first reported complication to Surgicel in the head and neck surgical field. We believe that this was a type four hypersensitivity reaction based on the timing of the event and the absence of any systemic symptoms.…”