Tissue Reaction following Intratracheal Application of Roentgen Contrast Media in Rats

Larsen, Lars Erik; Grant, Derek; Walday, Per

doi:10.1177/0284185195036s39932

Cited by 4 publications

(11 citation statements)

References 11 publications

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“…This effect was indicated by a lack of improvement of Pa,O 2 and low TLC35, V5 and Gruenwald index values and was more prominent when surfactant was dissolved in higher concentrations of saline-iodixanol. This data contrasts with the findings of LARSEN et al [25] concerning the effects of iodixanol. An important factor contributing to this contrast is the difference in methodology used.…”

Section: Discussioncontrasting

confidence: 99%

“…All the previous studies used animals with healthy lungs [17-24, 30, 31]. The same was true for LARSEN et al [25] who used rats with healthy lungs and showed that iodixanol did not cause tissue damage or lead to respiratory complications. This study was performed on rats with injured lungs who needed mechanical ventilation with high pressures and an Fi,O 2 of 1.0 to survive.…”

Section: Discussionmentioning

confidence: 78%

“…In this study, iodixanol was used as a contrast agent because it has been reported to be a safe agent when aspirated or directly instilled in the lungs [25]. Aspiration of a contrast media used for the roentgen examination of the upper gastrointestinal tract may cause severe respiratory insuffficiency.…”

Section: Discussionmentioning

confidence: 99%

“…As a result, it has been established that although some of these contrast media are not suitable to use for intrabronchial diagnostic procedures, other nonionic media did not cause harm to the respiratory system [17][18][19][20][21][22][23][24]31]. Similarly, LARSEN et al [25] reported that nonionic iso-osmolar contrast media, including iodixanol, when instilled intratracheally did not induce lung tissue damage or lead to respiratory complications.…”

Section: Discussionmentioning

confidence: 99%

“…However, it has been shown that nonionic and isotonic agents are well tolerated and cause fewer pulmonary complications than ionic and hyperosmolar agents [17-19, 23, 24]. LARSEN et al [25] reported that single intratracheal instillation of the nonionic, iso-osmolar, dimeric contrast medium iodixanol was unlikely to cause any significant tissue damage or lead to respiratory complications in healthy rat lungs. However, there is no data on the effect of contrast media when instilled or accidentally ingested into the ARDS lung.…”

mentioning

confidence: 99%

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Iodixanol inhibits exogenous surfactant therapy in rats with acute respiratory distress syndrome

Kesecioğlu¹,

Schultz²,

Haitsma³

et al. 2002

European Respiratory Journal

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Optimal alveolar distribution of exogenous surfactant is an important determinant of its beneficial effect. This distribution can be determined by suspending surfactant in a radiological contrast medium before intratracheal instillation, followed by radiological imaging. Iodixanol is reported to be a safe contrast medium that causes no lung injury when instilled intratracheally.In this study, the effects of surfactant suspended in saline were compared with surfactant suspended either in 4:1 saline-iodixanol (64 mg iodine?mL -1 ) or in 1:1 salineiodixanol (160 mg iodine?mL -1 ), on oxygenation and lung mechanics in a rat model of adult respiratory distress syndrome (ARDS) induced by lung lavage.After the induction of ARDS, surfactant instillation improved oxygenation, total lung volume at inflation with a distending pressure of 35 cmH 2 O, lung volume at transpulmonary pressure of 5 cmH 2 O and Gruenwald index. The effects of surfactant suspended in 4:1 saline-iodixanol were similar to those of surfactant alone. However, instillation of surfactant suspended in 1:1 saline-iodixanol resulted in significantly lower values in all measured parameters. Surface tension was the lowest in surfactant suspended in saline alone and addition of iodixanol led to an increase in surface tension in a dose-dependent manner.In conclusion, iodixanol at the higher dose caused an inhibition of the exogenous surfactant effect, characterized as a lack of improvement in oxygen tension in arterial blood, low total lung compliance, volume at 5 cmH 2 O end-expiration and Gruenwald index. This effect of iodixanol was probably due to its high surface tension, especially if a high concentration was used. Surfactant suspended in a lower concentration of iodixanol seems a better alternative, allowing for radiological imaging of the distribution of surfactant when intratracheally instilled.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 78%

Section: Discussionmentioning

confidence: 99%