Tissue platinum after clinical treatment with cisplatin or carboplatin in tumor-bearing patients

Abstract

Tissue platinum (Pt) levels were measured in tumor-bearing patients treated with either cisplatin or carboplatin. Cisplatin was given by intra-arterial, intraperitoneal, and intravenous (iv) administrations. After death, vertebrae and intervertebral disks were removed from eight human subjects, and livers and kidneys were removed from the half of them. When cisplatin was administered intraperitoneally, Pt of the liver was higher than that of the kidney, and a high content of Pt was detected in the vertebra by comparing with the other administration methods. At the intra-arterial administration of cisplatin, Pt was mainly accumulated in the kidney. At the iv administration of cisplatin, a high level of Pt was found in the vertebra and intervertebral disk, especially at the highest value at 10.31 micrograms/g in the intervertebral disk of one case, whereas a low level of Pt was detected in the liver. On the contrary, it was found that the iv administration of carboplatin did not result in high accumulations of Pt in the liver, kidney, intervertebral disk, and vertebra. Therefore, Pt is accumulated in different organs, depending on the way cisplatin is administered, but Pt is accumulated least in them by the administration of carboplatin.

Pharmacokinetics and tissue distribution of novel platinum containing anticancer agent BP‐C1 studied in rabbits using sector field inductively coupled plasma mass spectrometry

“…reported blood plasma pharmacokinetics and tissue distribution of cisplatin, carboplatin and 5 experimental anti‐cancer agents; main deposition was found for kidney for investigated agents. Noteworthy, in most distribution studies, which concern platinum‐containing drugs, mainly intravenous (for human‐based designs) or also intra‐peritoneal (for non‐clinical studies) routes of administration are employed . That is why media such as skin and muscle tissue are not investigated as usual.…”

Atomic Absorption Spectrometry Analysis of Trace Elements in Degenerated Intervertebral Disc Tissue

“…Minami et al [ 8 ] analyzed platinum levels in bone and IVD from cisplatin-treated ovarian cancer patients, and found that intradiscal metal accumulation after exposure exceeded bone accumulation by up to 4.3-fold. Other observations have also shown that in some cases TE concentrations can be higher in disc or bone tissue than in internal organs, such as liver and kidneys [ 9 ].…”