Tissue plasminogen activator in saliva of hypertensives treated with angiotensin converting enzyme inhibitors or calcium antagonists

Musumeci, V; Zappacosta, Bruno; Zuppi, Cecilia; Bizzi, G; Salvo, S. Di; Sacchi, Ada; Miani, C

doi:10.1097/00004872-199312050-00154

Journal of Hypertension

1993

DOI: 10.1097/00004872-199312050-00154

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Tissue plasminogen activator in saliva of hypertensives treated with angiotensin converting enzyme inhibitors or calcium antagonists

V Musumeci

Bruno Zappacosta²,

Cecilia Zuppi³

et al.

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2012

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“…15 Advantageous to scientists, several serum biomarkers associated with inflammation, atherosclerosis, plaque stability and myocardial damage are known and can appear in oral fluids. 16-21 However, a factor not yet well understood is which oral fluid would best reflect serum levels of these important biomarkers. To address this, we hypothesized that unstimulated whole saliva (UWS) would reflect myocardial status better than sublingual swabs (LS) or gingival swabs (GS).…”

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confidence: 99%

Oral fluids that detect cardiovascular disease biomarkers

Foley¹,

Sneed²,

Steinhubl³

et al. 2012

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

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Objective To determine the utility of oral fluids for assessment of coronary and cardiovascular (CVD) health. Study Design Twenty-nine patients with pre-existing CVD disease underwent an invasive cardiac procedure (alcohol septal ablation or percutaneous coronary intervention) and provided unstimulated whole saliva (UWS), sublingual swabs (LS), gingival swabs (GS) and serum at 0, 8, 16, 24, 48 hr. Concentrations of 13 relevant biomarkers were determined and correlated with levels in serum and the oral fluids. Results Concentrations of the majority of biomarkers were higher in UWS than LS and GS. Coronary and CVD disease biomarkers in UWS correlated better with serum than LS and GS based on group status and measures of time effect. Seven biomarkers demonstrated time effect changes consistent with serum biomarkers, including C-reactive protein and troponin I. Conclusions Changes in serum biomarker profiles are reflected in oral fluids suggesting that oral fluid biomarkers could aid in the assessment of cardiac ischemia/necrosis.

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mentioning

confidence: 99%

Oral fluids that detect cardiovascular disease biomarkers

Foley¹,

Sneed²,

Steinhubl³

et al. 2012

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

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“…30 Support for the use of saliva for the detection of CVD and myocardial infarction is built upon the framework that many serum biomarkers associated with inflammation, atherosclerosis, plaque stability and myocardial damage are known and appear in oral fluids. 4, 9, 31–35 However, only a limited number of studies have demonstrated correlations between serum and salivary biomarkers of CVD. 14, 33, 36 Thus, additional research is required if we are to gain a greater understanding of the clinical utility of saliva compared to serum with respect to CVD and myocardial infarction assessment.…”

mentioning

confidence: 99%

Salivary biomarkers associated with myocardial necrosis: results from an alcohol septal ablation model

Foley

Sneed

Steinhubl

et al. 2012

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

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Objective To determine if salivary biomarkers demonstrate utility for identifying aspects of myocardial necrosis. Methods Twenty-one patients undergoing alcohol septal ablation (ASA) for treatment of hypertrophic cardiomyopathy provided serum and unstimulated whole saliva at baseline and incremental time points post-ASA. Samples were analyzed for seven biomarkers related to myocardial damage, inflammation and tissue remodeling using immunosorbent assays. Levels were compared to baseline and levels observed in 97 healthy controls. Results Biomarkers of myocardial damage and inflammation (i.e., troponin I, creatine kinase-MB, myoglobin, C-reactive protein) rose in serum 2 to 812-fold after ASA (p<0.01). Significant elevations of 2 to 3.5-fold were observed with C-reactive protein and troponin I in saliva (p<0.02). Significant correlations between levels in serum and saliva were observed for C-reactive protein, matrix metalloproteinase-9, and myeloperoxidase (p < 0.001). Conclusions Select salivary biomarkers reflect changes that occur during, and subsequent to, myocardial necrosis caused by ASA.

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Tissue plasminogen activator in saliva of hypertensives treated with angiotensin converting enzyme inhibitors or calcium antagonists

Cited by 2 publications

References 0 publications

Oral fluids that detect cardiovascular disease biomarkers

Oral fluids that detect cardiovascular disease biomarkers

Salivary biomarkers associated with myocardial necrosis: results from an alcohol septal ablation model

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