Tissue phantom for optical diagnostics based on a suspension of microspheres with a fractal size distribution

Abstract

We demonstrate experimentally the possibility of reproducing the phase function, absorption, and scattering coefficients of a real biological tissue (adult brain white matter and liver) using a suspension of polystyrene microspheres with a fractal size distribution. The design of a light scattering goniometer with a cylindrical cell in air is discussed, and phase function measurements using the device are described. The scattering coefficient is measured using transmission spectrophotometry and the absorption and reduced scattering coefficients are measured using a time-resolved method. A good match between real tissue and phantom parameters is demonstrated.

Alternative Contrast Mechanism in Optical Coherence Tomography: Temporal Speckle Synchronization Effects

“…The absorption of polystyrene is negligible in near infrared range [35], thus scattering is the main determinant of light transport in this phantom model. Assuming that the scattering volume is defined by the Gaussian profile of the illuminating laser beam and the system's coherence length [36], there would be a large number of identical particles within the resolution element of the system. In other words, each analysed pair of pixel intensities within the polystyrene suspension ROI (see Figure 4) Alternative Contrast Mechanism in Optical Coherence Tomography: Temporal Speckle Synchronization Effects shape.…”

Estimation of optical abnormalities in breast phantom by diffuse equation

“…The routine of image reconstruction can be explained as the iteration method of BIM code, in the other word, the BIM code executes many times until the numerical reflectance fluences come close to the experimental data [2,12,13]. The image reconstruction is achieved through an iterative procedure where an objective function consisting of the difference between the measured and the modeled data is minimized.…”

Metal nanoparticles of different shapes influence on optical properties of multilayered biological tissues

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