Tissue Perfusion Diagnostic Classification Using a Spatio-temporal Analysis of Contrast Ultrasound Image Sequences

Williams, Quentin; Noble, J. Alison; Ehlgen, Alexander; Becher, Harald

doi:10.1007/11505730_19

Cited by 5 publications

(1 citation statement)

References 11 publications

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“…Multidimensional techniques such as Principal Components Analysis (PCA) and Factor Analysis (FA) have been proven effective at identifying time-intensity curves from series of images [3] [4]. The dual blood supply of the liver makes factor analysis a good tool candidate for improving the interpretability of these screenings.…”

Section: Introductionmentioning

confidence: 99%

Data Weighting for Principal Component Noise Reduction in Contrast Enhanced Ultrasound

Lueck

Burns

Martel

2006

Medical Image Computing and Computer-Assisted Intervention – MICCAI 2006

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Pulse inversion ultrasound is a mechanism for preferentially displaying contrast agent in blood vessels while suppressing signal from tissue. We seek a method for identifying and segmenting areas of the liver with similar statistically significant time intensity curves. As a first step in this process, a method of weighting Rayleigh distributed ultrasound image data before principal components analysis is presented. Simulation studies show that relative mean squared error can be reduced by 14% when the correct number of dimensions in selected. Our method is tested on an in vitro ultrasound phantom showing slightly increased error suppression, and is demonstrated on a clinical liver scan, showing decreased correlation between signals in the low intensity range.

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Section: Introductionmentioning

confidence: 99%

Data Weighting for Principal Component Noise Reduction in Contrast Enhanced Ultrasound

Lueck

Burns

Martel

2006

Medical Image Computing and Computer-Assisted Intervention – MICCAI 2006

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Cardiology Meets Image Analysis: Just an Application or Can Image Analysis Usefully Impact Cardiology Practice?

Noble

2005

Computer Vision for Biomedical Image Applications

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High resolution contrast ultrasound and NADH fluorescence imaging of myocardial perfusion in excised rat hearts

Kay

Swift

Sangave

et al. 2008

2008 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society

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Simultaneous imaging of myocardial flow and hypoxia could be vital for identifying acute ischemic mechanisms that may trigger an arrhythmia. We have studied the distribution of flow and hypoxia in excised locally ischemic rat hearts using simultaneous contrast ultrasound imaging and beta-nicotinamide adenine dinucleotide (NADH) fluorescence imaging. Local ischemia was induced by controlling flow within a major coronary artery. Intra-myocardial flow was imaged using contrast high-resolution ultrasound (linear probe; 13-6 MHz). An ultrasound contrast agent (UCA) was used to highlight the ischemic border. We observed distinct borders between two perfusion beds. UCA images showed high contrast borders of flow. The progression of UCA through the tissue was clearly visible. Intramyocardial regions of flow overlap could be identified by superimposing images of UCA from two perfusion zones. Borders between hypoxic and normoxic tissue were clearly revealed by increased NADH fluorescence. Hypoxic borders were oriented along borders of flow. In summary, simultaneous ultrasound and NADH imaging of excised hearts from small animals provide high fidelity images for characterizing the distribution of flow and hypoxic tissue during acute localized ischemia.

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Tissue Perfusion Diagnostic Classification Using a Spatio-temporal Analysis of Contrast Ultrasound Image Sequences

Cited by 5 publications

References 11 publications

Data Weighting for Principal Component Noise Reduction in Contrast Enhanced Ultrasound

Data Weighting for Principal Component Noise Reduction in Contrast Enhanced Ultrasound

Cardiology Meets Image Analysis: Just an Application or Can Image Analysis Usefully Impact Cardiology Practice?

High resolution contrast ultrasound and NADH fluorescence imaging of myocardial perfusion in excised rat hearts

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