Tissue oxygenation in peripheral muscles and functional capacity in cystic fibrosis: a cross‐sectional study

Abstract

New Findings What is the central question of this study?How do peripheral muscle tissue oxygenation and physical conditioning levels of children and adolescents with cystic fibrosis compare to demographically matched controls? What is the main finding and its importance?Children and adolescents with cystic fibrosis consumed more oxygen, more quickly and exhibited slower recovery, demonstrating that there may have been deficiencies in oxygen supply related to both oxygen uptake and oxygen transport. Abstract Cystic fibrosis affects skeletal muscle performance and functional capacity. However, it is currently unclear how peripheral muscle behaviour is affected, especially in children and adolescents. To examine this, we compared tissue oxygenation of children and adolescents with cystic fibrosis against healthy volunteers. We also evaluated the functional capacity of participants via the modified shuttle test (MST) and assessed for associations between performance and near‐infrared spectroscopy. A total of 124 participants enrolled. Participants were divided into either the cystic fibrosis group (CFG) or the healthy group (HG). Statistical comparisons between groups were evaluated with the Mann–Whitney U test and associations with functional capacity were evaluated using Spearman's correlation coefficient. CFG volunteers scored lower on the MST compared to the HG. They walked shorter distances (P = 0.001) with less efficiency because they performed the tests with a less efficient walking economy (P = 0.001) and a greater deoxyhaemoglobin concentration (P = 0.001). Further, they experienced reduced tissue oxygen saturation (P = 0.037) faster than the HG. As a result, they presented lower respiratory (P = 0.001) and lower heart (P = 0.001) rate values at the end of the MST, with a longer post‐test heart rate recovery time (P = 0.005). There was a significant association between deoxygenation time and functional capacity. The CFG consumed more oxygen, more quickly, with a slower recovery, reflecting impairments in the dynamics of muscle oxygen extraction. The results suggest differences in functional capacity and haemodynamic recovery in children and adolescents with cystic fibrosis.

Wearing a Surgical Face Mask Has Minimal Effect on Performance and Physiological Measures during High-Intensity Exercise in Youth Ice-Hockey Players: A Randomized Cross-Over Trial

“…However, we did find that tissue oxygenation in the quadriceps was lower in the masked versus sham condition for the submaximal "shifts" in males and the maximal "shift" in females. While these decreases in muscle tissue oxygenation were statistically lower in the masked vs. sham condition, the absolute difference between masked and unmasked conditions was quite small (0.4-2.8%) and within the range observed in previous research in adults during masked and unmasked exercise [15], as well as in research involving children of a similar age during exercise without wearing masks [27]. Thus, any differences are likely to have minimal clinical importance.…”

Comparison of the modified shuttle walk test in children with cystic fibrosis and healthy controls

“…Of the investigations that used the MSWT in children with CF (Coelho et al., 2007, 2020; Cox et al., 2006; del Corral et al., 2020; Pérez et al., 2014; Urquhart et al., 2012; Vendrusculo et al., 2019; Vendrusculo et al., 2020), the present study had the lowest average age and smallest age range, thus confirming the sample as exclusively pediatric. Research by Vendrusculo et al.…”

“…Of the investigations that used the MSWT in children with CF (Coelho et al, 2007(Coelho et al, , 2020Cox et al, 2006;del Corral et al, 2020;Pérez et al, 2014;Urquhart et al, 2012;Vendrusculo et al, 2019;Vendrusculo et al, 2020), the present study had the lowest average It is important to note that, although our results showed no relationship between distance walked and age, some of the younger participants had difficulty understanding the MSWT and showed a lack of motivation to perform the test. This behavior may have compromised the actual exercise capacity of some children, since studies have shown that performance in this population depends on motivation and age (Bento et al, 2017).…”

Active video gaming in primary ciliary dyskinesia: a randomized controlled trial

“…PCD patients have reduced peak oxygen consumption due to decreased PF and PAL [ 6 ]. Peripheral muscle tissue oxygenation is associated with functional capacity in CLD [ 25 ]. Our results showed a 46.6 m and 48.12 m increase in the 6MWD and ISWD, respectively, with AVGs.…”