Tissue oxygen tension monitoring of organ perfusion: rationale, methodologies, and literature review

Santis, Vincenzo De; Singer, Mervyn

doi:10.1093/bja/aev162

Cited by 50 publications

(37 citation statements)

References 94 publications

(75 reference statements)

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“…Comparably, much less attention has been put onto pO 2 under clinical conditions. pO 2 can be used to describe the partial pressure of oxygen within the interstitial space of a particular tissue, representing the balance between local oxygen delivery and consumption at any given time [12]. The concept of pO 2 should be of great importance as well, especially in blood-thinning regions or inside solid tumors, where limited vessels exist to transmit oxygen, or diffusion-limited effects block oxygen transmission into the solid tumors.…”

Section: Introductionmentioning

confidence: 99%

Photoacoustic Imaging in Oxygen Detection

Cao

Qiu

et al. 2017

Applied Sciences

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Oxygen level, including blood oxygen saturation (sO 2 ) and tissue oxygen partial pressure (pO 2 ), are crucial physiological parameters in life science. This paper reviews the importance of these two parameters and the detection methods for them, focusing on the application of photoacoustic imaging in this scenario. sO 2 is traditionally detected with optical spectra-based methods, and has recently been proven uniquely efficient by using photoacoustic methods. pO 2 , on the other hand, is typically detected by PET, MRI, or pure optical approaches, yet with limited spatial resolution, imaging frame rate, or penetration depth. Great potential has also been demonstrated by employing photoacoustic imaging to overcome the existing limitations of the aforementioned techniques.

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Section: Introductionmentioning

confidence: 99%

Photoacoustic Imaging in Oxygen Detection

Cao

Qiu

et al. 2017

Applied Sciences

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“…To construct bacteria biosensors that can distinguish unique organ signatures, we chose oxygen, pH and lactate as physiological indicators, as they are predominantly found throughout the body (32)(33)(34)(35)(36). To sense oxygen, we utilized a hypoxia-sensing promoter (pPepT) that is primarily regulated by the transcriptional activator, fumarate and nitrate reduction regulatory protein (FNR) (30,37,38) (Fig.…”

mentioning

confidence: 99%

Multiplexed biosensors for precision bacteria tropism in vivo

Chien

Harimoto

Kepecs

et al. 2019

Preprint

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The engineering of microbes spurs biotechnological innovations, but requires control mechanisms to confine growth within defined environments for translation. Here we engineer bacterial growth tropism to sense and grow in response to specified oxygen, pH, and lactate signatures. Coupling biosensors to drive essential gene expression reveals engineered bacterial localization within upper or lower gastrointestinal tract. Multiplexing biosensors in an AND logicgate architecture reduced bacterial off-target colonization in vivo.

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“…The tissue oxygenation represents the balance between the local oxygen delivery and consumption, which relates to both the organ's metabolic activity and its blood flow (1). Near-infrared radiation is capable of transmitting through the body tissues due to the property which is scarcely absorbed by water and hemoglobin, and the scatter of the radiation is less than that of ultraviolet or visible radiation (2).…”

Section: Introductionmentioning

confidence: 99%

Tissue oxygenation index reflects changes in forearm blood flow after brief ischemia

et al. 2017

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: Whether the near-infrared spectroscopy (NIRS) technology correctly detects the changes in oxygenation related to ischemia and reperfusion of organs and tissues other than brain remains unclear. The present study examined how different tissue oxygenation parameters derived from NIRS reflect the changes in the forearm blood flow (FBF) according to the brief ischemia and the subsequent reperfusion, and whether values of these parameters move in parallel with the medial and lateral sides of FBF. Thirteen volunteers underwent the prospective observational study. The tissue oxygenation index (TOI), regional saturation of oxygen (rSO2), skin tissue oxygenation (StO2), and FBF values were evaluated in the forearm. Medial rSO2 values at 1 to 3 minutes after the termination of brief ischemia were higher than lateral rSO2 and respective TOI values. FBF and StO2 values quickly increased according to the cessation of brief ischemia, whereas the medial and lateral values did not differ during and after the brief ischemia. TOI and StO2, but not rSO2, reflected changes in FBF of both medial and lateral sides simultaneously in response to the reperfusion after brief ischemia. The muscle tissue oxygenation during reperfusion favors the use of TOI and StO2, but not rSO2, as the surrogate parameter.

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Tissue oxygen tension monitoring of organ perfusion: rationale, methodologies, and literature review

Cited by 50 publications

References 94 publications

Photoacoustic Imaging in Oxygen Detection

Photoacoustic Imaging in Oxygen Detection

Multiplexed biosensors for precision bacteria tropism in vivo

Tissue oxygenation index reflects changes in forearm blood flow after brief ischemia

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