Tissue‐of‐origin for cancers determines HIF‐1 activation induced phenotypic heterogeneity
Shaofei Liu,
Yamin Liu,
Xihua Qiu
et al.
Abstract:Hypoxia‐inducible factor‐1 (HIF‐1) is the master regulator of cellular response to hypoxia, and is activated in many cancers contributing to many steps in the metastatic cascade by acting as a key transcription co‐regulator for a large number of downstream genes. Presence of hypoxia within a tumor is spatially nonuniform, and can also by dynamic. Further, although HIF‐1 is primarily stabilized and activated by lack of molecular O2, its stability is also affected by other factors present in the tumor microenvir… Show more
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