Tissue O2 Supply Under Normal and Pathological Conditions

Radical-scavenging activity of butylated hydroxytoluene (BHT) and its metabolites

“…In contrast, phenoxyl radicals can easily react with oxygen at high oxygen tensions, and consequently may be regenerated to the parent phenolic compounds and/or undergo much more oxidation because oxygen is a biradical. In living organisms, the partial pressure of oxygen may be rather low (Kessler et al, 1984;Burton and Ingold, 1984). Pryor et al previously reported that menadione, a quinone, or beta-carotene, a polyene, did not behave as antioxidants in their system under aerobic conditions, since the induction period was too small to measure, suggesting that the kinetic study of quinones and polyenes might be difficult.…”

“…We thought that these differences may be associated with the oxygen levels in the different experimental systems. The oxygen tension under a 15 Torr oxygen atmosphere is similar to that in many tissues (Kessler et al, 1984;Burton and Ingold, 1984), suggesting that oxygen is scarce in living cells. Previous quantitative in vitro studies were performed under aerobic conditions, and the efficiency of antioxidants may differ considerably between aerobic and anaerobic conditions.…”

Regulation of capillary blood flow and oxygen supply in skeletal muscle in dogs during hypoxaemia.

“…7 Kessler et al (1984) and Hoper (1984). The question not yet answered, however, is, where does the increased blood flow from the femoral artery (see Fig.…”

Establishment of a human fibroblast cell line producing tumor necrosis factor α (KMST-6/TNF) and growth inhibitory effects of its conditioned medium on malignant cells in culture

“…For example, modes of oxygen tension histograms in liver, brain, and skeletal muscle lie within a range of 15-30 mm Hg ( 2 4 % 02) (Kessler et al, 1984). In the present experiments, the KMST-6/TNF CM was effective even under 1% oxygen tension, suggesting that this CM may be effective for in vivo administration.…”