Tissue necrosis after canine bothropic envenoming: a case report

Júnior, Rui Seabra Ferreira; Barraviera, Benedito

doi:10.1590/s0104-79302001000200011

Cited by 5 publications

(9 citation statements)

References 4 publications

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“…The necrotic action, also called proteolytic, results from the direct citotoxic action in tissues by venom proteolytic fractions, which induce release of vasoactive substances, such as bradykynin and histamine, causing extensive local reaction including pain, edema, congestion, hemorrhage, and necrosis (13,32,40,41,65,71,74). These lesions can be potentialized by secondary infections (9,12,13).…”

Section: Bothrops Envenomingmentioning

confidence: 99%

“…Edema at bite site (Figure 3) is the most evident symptom of Bothrops envenoming; its severity is directly proportional to the time elapsed since venom injection (32,41).…”

Section: Clinical Signsmentioning

confidence: 99%

“…Pain is quite evident, especially at bite site, preventing the animals from moving with great difficulty (19,31,32).…”

Section: Clinical Signsmentioning

confidence: 99%

“…Mortality by Bothrops envenoming is low, but major sequelae can limit the animal's physical capacity if it does not receive appropriate treatment (32).…”

Section: Sequelae and Complicationsmentioning

confidence: 99%

“…According to Bicudo (19), statistics about domestic envenomings are scarce in veterinary literature (32).…”

Section: Introductionmentioning

confidence: 99%

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Management of venomous snakebites in dogs and cats in Brazil

Ferreira¹,

Barravieira²

2004

J. Venom. Anim. Toxins incl. Trop. Dis

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Snake envenoming is a major problem both to veterinary and human medicine in tropical countries due to high incidence, severity, and sequelae. In Brazil, most envenomings involving animals are caused by Bothrops and Crotalus snakes; these are the highest risk to animals. This study reports on Bothrops and Crotalus envenomings in dogs, the main species responsible for epidemiology, pathogenesis, venom action, clinical signs, sequelae and complications, clinical pathology, necropsy findings, diagnosis, and treatment. Veterinarians must be capable of identifying the snake not only by observing its characteristics but also symptom evolution

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Section: Bothrops Envenomingmentioning

confidence: 99%

“…Edema at bite site (Figure 3) is the most evident symptom of Bothrops envenoming; its severity is directly proportional to the time elapsed since venom injection (32,41).…”

Section: Clinical Signsmentioning

confidence: 99%

“…Pain is quite evident, especially at bite site, preventing the animals from moving with great difficulty (19,31,32).…”

Section: Clinical Signsmentioning

confidence: 99%

“…Mortality by Bothrops envenoming is low, but major sequelae can limit the animal's physical capacity if it does not receive appropriate treatment (32).…”

Section: Sequelae and Complicationsmentioning

confidence: 99%

“…According to Bicudo (19), statistics about domestic envenomings are scarce in veterinary literature (32).…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Management of venomous snakebites in dogs and cats in Brazil

Ferreira¹,

Barravieira²

2004

J. Venom. Anim. Toxins incl. Trop. Dis

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Repurposed drugs and their combinations prevent morbidity-inducing dermonecrosis caused by diverse cytotoxic snake venoms

Hall,

Rasmussen,

Crittenden

et al. 2023

Nat Commun

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Morbidity from snakebite envenoming affects approximately 400,000 people annually. Tissue damage at the bite-site often leaves victims with catastrophic life-long injuries and is largely untreatable by current antivenoms. Repurposed small molecule drugs that inhibit specific snake venom toxins show considerable promise for tackling this neglected tropical disease. Using human skin cell assays as an initial model for snakebite-induced dermonecrosis, we show that the drugs 2,3-dimercapto-1-propanesulfonic acid (DMPS), marimastat, and varespladib, alone or in combination, inhibit the cytotoxicity of a broad range of medically important snake venoms. Thereafter, using preclinical mouse models of dermonecrosis, we demonstrate that the dual therapeutic combinations of DMPS or marimastat with varespladib significantly inhibit the dermonecrotic activity of geographically distinct and medically important snake venoms, even when the drug combinations are delivered one hour after envenoming. These findings strongly support the future translation of repurposed drug combinations as broad-spectrum therapeutics for preventing morbidity caused by snakebite.

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Diagnóstico e tratamento de acidente ofídico por serpente do gênero Bothrops em cão

Alves¹,

Pereira²,

Barreto³

et al. 2020

Vet Not

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Refere-se como acidente ofídico todo quadro de envenenamento decorrente da inoculação de veneno, através de presas de serpentes. O veneno das espécies do gênero Bothrops, ao ser inoculado no animal, causa sinais clínicos graves que, se não tratados o mais rapidamente possível, podem levar o animal ao óbito. O gênero Bothrops (jararacas) está distribuído por todo o território nacional sendo responsável pela maioria dos acidentes ofídicos no país. Diante disso, o objetivo do presente relato foi descrever o diagnóstico e tratamento hospitalar bem sucedido de acidente botrópico em cão.

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Tissue necrosis after canine bothropic envenoming: a case report

Cited by 5 publications

References 4 publications

Management of venomous snakebites in dogs and cats in Brazil

Management of venomous snakebites in dogs and cats in Brazil

Repurposed drugs and their combinations prevent morbidity-inducing dermonecrosis caused by diverse cytotoxic snake venoms

Diagnóstico e tratamento de acidente ofídico por serpente do gênero Bothrops em cão

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