Tissue Microarray Assessment of Selenoprotein P Expression in Gastric Adenocarcinoma

Wang, Q; Gong, Lin; Dong, Rui; Qiao, Qing; Xl, He; Yk, Chu; Xl, Du; Yang, Yixin; Zang, Li; Nan, Jing; Lin, Chin‐Teng; Lu, J. Y.

doi:10.1177/147323000903700120

Cited by 9 publications

(8 citation statements)

References 16 publications

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“…[41][42][43][44][45][46][47] The quantitative analysis of serum SeP in this study using ELISA revealed a marked decrease in SeP levels in HCC group as compared to CLD and healthy control groups (p < 0.01). These results confirmed the findings of Li et al 48 who reported that SeP mRNA expression was significantly lower in HCC tissues compared to that of normal liver and cirrhosis, suggesting that SeP might play a role in the occurrence and development of HCC.…”

Section: Discussionmentioning

confidence: 99%

Role of microRNA-7 and selenoprotein P in hepatocellular carcinoma

et al. 2017

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Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). IntroductionHepatocellular carcinoma (HCC) represents the fifth most common cancer and the third most leading cause of cancer-related deaths worldwide. 1 High morbidity observed in HCC is majorly attributed to the lack of early detection markers and poor prognosis. Hence, exploration of novel frontiers in HCC diagnosis and therapeutics remains to be high priority research areas. 2,3 HCC represents a public health problem in Egypt. It constitutes 70.48% of all liver tumors among Egyptians, representing the second most common malignancy after bladder cancer in men and breast cancer in women and the second most common cause of death in men. 4,5 Alpha-fetoprotein (AFP) is the most widely used tumor biomarker for HCC diagnosis. However, it has low sensitivity and specificity. This highlights the need for other methods that would be minimally invasive, simple, and reliable. 6 MicroRNAs (miRNAs) are a class of short non-coding RNAs, which play a central role in sequence specific posttranscriptional gene attenuation. 7 They are involved in various fundamental cellular processes as well as carcinogenesis. Moreover, miRNAs are highly stable in serum due to their resistance to RNase, extreme pH, and temperature. Therefore, they have been identified as candidate AbstractThere is an obvious need to diagnose hepatocellular carcinoma using novel non-invasive and sensitive biomarkers. In this regard, the aim of this study was to evaluate and correlate both relative quantification of microRNA-7 using quantitative real time polymerase chain reaction and quantitative analysis of selenoprotein P using enzyme-linked immunosorbent assay in sera of hepatocellular carcinoma patients, chronic liver disease patients, as well as normal healthy subjects in order to establish a new diagnostic biomarker with a valid non-invasive technique. In addition, this study aimed to investigate whether changes in selenium supply affect microRNA-7 expression and selenoprotein P levels in human hepatocarcinoma cell line (HepG2). The results showed a highly significant decrease in serum microRNA-7 relative quantification values and selenoprotein P levels in malignant group in comparison with benign and control groups. The best cutoff for serum microRNA-7 and selenoprotein P to discriminate hepatocellular carcinoma group from benign and control groups was 0.06 and 4.30 mg/L, respectively. Furthermore, this study showed that changes in selenium supply to HepG2 cell line can alter the microRNA-7 profile and are paralleled by changes in the concentration of its target protein (selenoprotein P). Hence, serum microRNA-7 ...

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Section: Discussionmentioning

confidence: 99%

Role of microRNA-7 and selenoprotein P in hepatocellular carcinoma

et al. 2017

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“…Core annular flow with the water-in-oil emulsion in the core surrounded by a water layer developed at high water fractions and mixture velocities. The formation of core annular flow in the experiments of Wang et al [25] can be linked to the self-lubricated bitumen froth reported in Joseph et al [20] and Sanders et al [24] In these studies, the formation of core annular flow requires high flow rates under which the water migrates into the wall region of high shear.…”

Section: Literature Reviewmentioning

confidence: 82%

“…Also, the free water fraction of self-lubricated bitumen froth was less than 10 % of the total froth volume, which is much lower than the water fraction that would normally be considered feasible for stable waterlubricated transport of viscous crude oils. [24] Wang et al [25] experimentally investigated the concurrent flow of heavy crude and water in a horizontal steel pipe. The crude oil (viscosity around 628 mPa Á s at 60 8C) and water were collected from an oil field.…”

Section: Literature Reviewmentioning

confidence: 99%

“…Water-in-oil emulsion has been reported to have increased effective mixture viscosity with increase of water content, which can also result in higher pressure gradient with increase in water content. [25] When discontinuous water streams can be observed, the streams of water partially lubricate the pipe and contribute to a reduced average pressure gradient. Figure 5b shows a typical pressure trend for the majority of experimental runs.…”

Section: Inversion Occurrencementioning

confidence: 99%

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An experimental investigation of high‐viscosity oil‐water flow in a horizontal pipe

2017

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An experimental investigation on high‐viscosity oil‐water flow in a horizontal pipe (I.D. = 26 mm) has been conducted. The oil viscosity investigated varied between 3800 and 16 000 mPa · s. Flow patterns observed in experiments are presented and flow pattern maps are reported. The inversion from oil‐continuous to annular‐water‐continuous is discussed. The average pressure gradient of oil‐continuous two‐phase flow can be reduced before the inversion to annular‐water‐continuous flow due to partial lubrication from discontinuous water streams. The stable water‐lubricated flow develops at a lower input water volume fraction with increase of the superficial oil velocity. An empirical criterion for the formation of stable water‐lubricated flow was proposed in terms of the oil phase Froude number and the input water volume fraction. The friction factor of water‐lubricated flow can be one to two orders of magnitude higher than that of single‐phase water flow and has a faster decrease with increase of the Reynolds number than that of single‐phase turbulent flow. These are linked to the oil fouling on the pipe wall. Models for the prediction of the pressure gradient of core flow proposed by different authors in the literature were evaluated with the experimental data.

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“…In this sense, the increased SELENOP in M2 macrophages may offset the loss of SELENOP in tumor cells and support metastasis by supplying this in a paracrine manner, although this has not been tested experimentally. This may depend also on the location of cancer as a study of gastric adenocarcinoma found that SELENOP expression was low in cancer tissues compared with control tissues and was related to the degree of gastric adenocarcinoma differentiation but not to tumor node metastasis stage (Wang et al, 2009). …”

Section: Other Potential Roles For Selenoproteins In Metastasismentioning

confidence: 99%

Selenoproteins and Metastasis

Marciel

Hoffmann

2017

Advances in Cancer Research

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Cancer survival is largely impacted by the dissemination of cancer cells from the original tumor site to secondary tissues or organs through metastasis. Targets for anti-metastatic therapies have recently become a focus of research, but progress will require a better understanding of the molecular mechanisms driving metastasis. Selenoproteins play important roles in many of the cellular activities underlying metastasis including cell adhesion, matrix degradation and migration, invasion into the blood and extravasation into secondary tissues, and subsequent proliferation into metastatic tumors along with the angiogenesis required for growth. In this review the roles identified for different selenoproteins in these steps and how they may promote or inhibit metastatic cancers is discussed. These roles include selenoenzyme modulation of redox tone and detoxification of reactive oxygen species, calcium homeostasis and unfolded protein responses regulated by endoplasmic reticulum selenoproteins, and the multiple physiological responses influenced by other selenoproteins.

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Tissue Microarray Assessment of Selenoprotein P Expression in Gastric Adenocarcinoma

Cited by 9 publications

References 16 publications

Role of microRNA-7 and selenoprotein P in hepatocellular carcinoma

Role of microRNA-7 and selenoprotein P in hepatocellular carcinoma

An experimental investigation of high‐viscosity oil‐water flow in a horizontal pipe

Selenoproteins and Metastasis

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