Tissue mechanics during temporal summation of sequentially cuff pressure‐induced pain in healthy volunteers and patients with painful osteoarthritis

Manafi-Khanian, Bahram; Petersen, Kristian Kjær; Arendt-Nielsen, Lars

doi:10.1002/ejp.1006

Cited by 3 publications

(4 citation statements)

References 35 publications

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“…In the process of pain chronification structural reorganization of synapses, cells and circuits also occur at various anatomical and temporal scales 19,21 . These system-wide changes leave chronic pain patients with a completely altered nociceptive system; often with localized and widespread hyperalgesia 21,22 , dysfunctional descending pain control [23][24][25] facilitated temporal summation of pain 24,[26][27][28] , and occasionally even allodynia 20 . Fortunately, the neuroplasticity that underlies these dysfunctional changes leaves hope that the pathologies can be diminished, or even reversed, by treatments specifically targeting these mechanisms.…”

Section: Neuroplasticity and Painmentioning

confidence: 99%

“…21,25,222,234,236,238 . In the present work, the dynamic QST was assessed with userindependent cuff pressure algometry, which has shown excellent reliability 27,[238][239][240][241][242] . An illustration of the cuff pressure algometry setup is shown in Fig.…”

Section: Modulating Central Pain Mechanisms In Healthy Pain-free Subj...mentioning

confidence: 99%

“…The up-stream mechanism of TSP refers to the progressive increase in neuronal output during a train of identical afferent nociceptive stimuli 21,27 . Facilitation of temporal summation is a result of endogenous upregulation of the central integrative mechanism and is considered a measure of increased central gain of pain 21,234 .…”

Section: Temporal Summation Of Painmentioning

confidence: 99%

“…Facilitation of temporal summation is a result of endogenous upregulation of the central integrative mechanism and is considered a measure of increased central gain of pain 21,234 . Facilitated TSP has been demonstrated in various pain conditions, including osteoarthritis 27,244,245 , post-operative pain 26,246 , fibromyalgia 247 , neuropathic pain 248 and more 21,24,249,250 . TSP is assessed by applying ten short-lasting stimuli at PTT level with 0.5 Hz frequency 234,240 .…”

Section: Temporal Summation Of Painmentioning

confidence: 99%

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Modulating the somatosensory system using high-definition transcranial direct current stimulation

Kold¹

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Section: Neuroplasticity and Painmentioning

confidence: 99%

Section: Modulating Central Pain Mechanisms In Healthy Pain-free Subj...mentioning

confidence: 99%

Section: Temporal Summation Of Painmentioning

confidence: 99%

Section: Temporal Summation Of Painmentioning

confidence: 99%

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Modulating the somatosensory system using high-definition transcranial direct current stimulation

Kold¹

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Reliability of measurements for sub-painful and painful perception on artificial electrical stimulations

Chan

Peng

Chan

2018

International Journal of Psychophysiology

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Modulation of Exercise-Induced Hypoalgesia Following an Exercise Intervention in Healthy Subjects

et al. 2020

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Background Exercise is recommended to promote and maintain health and as treatment for more than 25 diseases and pain conditions. Exercise-induced hypoalgesia (EIH), a measure of descending pain inhibitory control, has been found to be impaired in some chronic pain conditions, but it is currently unclear if EIH is modifiable. This study investigated whether a long-term exercise intervention could modulate EIH in healthy subjects. Methods In 38 healthy subjects, EIH was assessed as change in pressure pain threshold (PPT) after a three-minute isometric wall squat within the first week and after approximately seven weeks of military training (MT). Further, temporal summation of pain (TSP) and Knee injury and Osteoarthritis Outcome Score (KOOS) were assessed. Physical performance capacity was assessed using the Endurance 20-m shuttle run fitness test (20MSR). Hypoalgesic (EIH > 0.0 kPa) and hyperalgesic (EIH ≤ 0.0 kPa) subgroups were defined based on baseline EIH. Change in EIH following MT was used as the primary outcome. Results Increased EIH (P = 0.008), PPT (P < 0.003), and 20MSR (P < 0.001) were found following MT, with no changes in TSP and KOOS (P > 0.05). Subjects with a hyperalgesic EIH response at baseline (26% of the participants) presented significantly improved EIH following MT (P = 0.010). Finally, an association between 20MRS change and EIH change was found (r = 0.369, P = 0.023). Conclusions MT increased EIH, especially in subjects who demonstrated a hyperalgesic response at baseline. Improvement in physical performance capacity was associated with an improvement in EIH, indicating that improvement in physical performance capacity may improve central pain mechanisms.

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Tissue mechanics during temporal summation of sequentially cuff pressure‐induced pain in healthy volunteers and patients with painful osteoarthritis

Abstract: The temporal summation of pain during sequential cuff stimulation is inexplicable by the time-dependent response of mechanical stress and strain in soft tissue.

Cited by 3 publications

References 35 publications

Modulating the somatosensory system using high-definition transcranial direct current stimulation

Modulating the somatosensory system using high-definition transcranial direct current stimulation

Reliability of measurements for sub-painful and painful perception on artificial electrical stimulations

Modulation of Exercise-Induced Hypoalgesia Following an Exercise Intervention in Healthy Subjects

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