Tissue levels of adiponectin, tumour necrosis factor‐alpha, soluble intercellular adhesion molecule‐1 and heart‐type fatty acid‐binding protein in human coronary atherosclerotic plaques

Abstract

The data are in accord with those in prior publications on the detection and quantification of various inflammatory cytokines in atherosclerotic plaques. Our results indicate that diabetic state and smoking, in addition to other physiopathological mechanisms, may create a chronic inflammatory situation in the atherosclerotic process.

The associations between serum leptin, adiponectin and intercellular adhesion molecule-1 in hypercholesterolemic patients

“…These results are consistent with the previous human studies demonstrating the negative correlation between plasma adiponectin and ICAM-1 and positive correlation between plasma leptin and ICAM-1 (Kent et al, 2004). Karaduman et al (2006 )reported that ICAM-1 levels were negatively correlated with adiponectin levels from human coronary atherosclerotic plaque.…”

Adiponectin and Vulnerable Atherosclerotic Plaques

“…Adiponectin partakes in inflammatory factor propagation by adhesion molecule expression (39). Inhibition of the TNF-induced activation of nuclear factor kappa-B-dependent proinflammatory cAMP pathway (35,36) reduces the expression of adhesion molecules such as vascular cell adhesion molecule-1, intercellular adhesion molecule-1, and E selectin (39,(108)(109)(110), all of which have been detected in atherosclerotic lesions (111). Local adiponectin to intima and adventitia of endothelial wall suppresses the expression of vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 in vascular walls, suggesting that adiponectin improves atherosclerosis in part by inhibition of the expression of these inflammatory molecules in vivo (112).…”

Implication of lipocalin-2 and visfatin levels in patients with coronary heart disease

“…Lower serum adiponectin levels have been reported in patients with coronary heart disease (CHD) (2,3) and have been shown to be a risk factor for cardiovascular events (4). In addition, it has recently been suggested that IL-6, TNF-a, leptin, and adiponectin may not only be just markers of inflammation and cardiovascular (CV) risk but are also likely to play a pathogenic role in atheromatous plaque (5,6).…”