Tissue levels of adiponectin in breast cancer patients

Abstract

Our results suggest that the high tissue adiponectin levels significantly detected in breast cancer patients and associated with an increased risk for breast cancer.

Associations of Single Nucleotide Polymorphisms in the Adiponectin Gene with Adiponectin Levels and Cardio-Metabolic Risk Factors in Patients with Cancer

“…The recent finding of increased levels of tissue adiponectin in breast cancer patients compared to controls gives further support to our finding of an association between an SNP that causes higher adiponectin levels and cancer [39]. The study by Karaduman et al, also reported that, women with high levels of tissue adiponectin are at increased risk of developing breast cancer than women with low tissue adiponectin levels [39]. Another recent study has reported that serum adiponectin levels were higher in advanced than organ confined prostate cancer [40].…”

“…Furthermore, different SNPs in adiponectin gene can give rise to more than one allelic messenger ribose nucleic acid (mRNA) forms which in turn possess different biological functions as a result of differences in primary or higher order structures that interact with other cellular components [38]. The recent finding of increased levels of tissue adiponectin in breast cancer patients compared to controls gives further support to our finding of an association between an SNP that causes higher adiponectin levels and cancer [39]. The study by Karaduman et al, also reported that, women with high levels of tissue adiponectin are at increased risk of developing breast cancer than women with low tissue adiponectin levels [39].…”

The Relationship between Adiponectin and Breast Cancer

“…Adiponectin also inhibits nuclear factor-Kβ activation, which is effective in the development of breast cancer (15). For these reasons, various studies have shown the relationship between decreased adiponectin levels and breast cancer (16,17). Although the relationship between plasma adiponectin levels and breast cancer in postmenopausal patients has been demonstrated, the relationship between adiponectin levels and cancer in premenopausal women has not been clearly displayed (18)(19)(20).…”

Associations between Adiponectin and Two Different Cancers: Breast and Colon

“…In breast cancer it is likely that obesity is often related to estrogen reseptor status (Kang et al, 2007;Grossmann et al, 2008;Karaduman et al, 2007). In 2008, Grossmann ME and colleagues revealed that estrogen receptor positive MCF-7 and T47D cells were inhibited at lower adiponectin concentrations than ER-negative SK-BR-3 cells (Grossmann et al,2008).…”