Tissue-Level Dynamics and Redox State of Coenzyme Q10 in Rats After Intravenous Injection of Ubiquinol

Kalenikova, E. I.; Gorodetskaya, E. A.; Obolenskaya, O. N.; Shapoval, N. S.; Медведев, О. С.

doi:10.1007/s11094-018-1882-6

Cited by 7 publications

(4 citation statements)

References 17 publications

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“…However, the amount of endogenous CoQ10 was also depleted in the contralateral hemisphere, most likely because the brain is a common functioning system and pathological ischemic processes affect both hemispheres. In previous pharmacokinetic studies on an innovative dosage form of ubiquinol, it was shown that four days after a single intravenous administration, the level of coenzyme Q10 in the brain remains significantly increased [13]. Intravenous administration of ubiquinone and ubiquinol resulted in the restoration of total coenzyme Q10 level in the brain in both hemispheres to the value of native animals.…”

Section: Discussionmentioning

confidence: 98%

“…In the The obtained data convincingly indicate that without treatment, the area of brain damage continues to increase in the delayed period after ischemia within at least four days, perhaps because of the penumbra zone growing, which opens up additional opportunities for therapeutic action, for example, repeated administration of neuroprotective substances. According to the data published earlier, it was shown that after a single injection of ubiquinol, elevated coenzyme Q10 levels persisted in the brain (by 60%) and in the liver (20-times) at least for four days [13]. Most likely a single injection of ubiquinol is sufficient to limit brain damage in the delayed period.…”

Section: Coq10 Brain Levelmentioning

confidence: 94%

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Intravenous Administration of Coenzyme Q10 in Acute Period of Cerebral Ischemia Decreases Mortality by Reducing Brain Necrosis and Limiting Its Increase within 4 Days in Rat Stroke Model

et al. 2020

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Oxidative stress plays a key role in the pathogenesis of ischemic stroke. Coenzyme Q10 has a multi-targeting effect and may protect the brain against ischemic damage. The aim of our study was to evaluate the neuroprotective potential of ubiquinol by its intravenous administration. The study was performed on rats; a stroke was modeled by occlusion of the middle cerebral artery. On days 1 and 4 after ischemia, the neurological deficit and volume of the brain lesion were determined by MRI and TTC staining. Intravenous administration of coenzyme Q10 led to a decrease in rat mortality rate, improvement in neurological status, and decrease in the brain necrosis area in acute and delayed period after cerebral ischemia. A single intravenous administration of ubiquinol led to a limitation of the size of the brain damage for at least four days after ischemia. Thus, intravenous administration of coenzyme Q10 has a persistent neuroprotective potential. This finding suggests a possible therapeutic role of ubiquinol in acute ischemic conditions.

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Section: Discussionmentioning

confidence: 98%

Section: Coq10 Brain Levelmentioning

confidence: 94%

Intravenous Administration of Coenzyme Q10 in Acute Period of Cerebral Ischemia Decreases Mortality by Reducing Brain Necrosis and Limiting Its Increase within 4 Days in Rat Stroke Model

et al. 2020

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“…The ubiquinol reverse reduction activates endogenous regeneration systems (tocopherol and ascorbate) (Gille et al, 2008). The ratio between oxidized and reduced CoQ10 species is a biomarker for oxidative stress in vivo (Kalenikova et al, 2018). The ubiquinone therapeutic effectiveness has been reported in many diseases affecting this pathogenetic factor (Chan et al, 2015).…”

Section: Biosynthesis Of Coq and Its Neuroprotective/antioxidant E Ec...mentioning

confidence: 99%

Neuroprotective effects of coenzyme Q10 on neurological diseases: a review article

Bagheri,

Haddadi,

Saki

et al. 2023

Front. Neurosci.

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Neurological disorders affect the nervous system. Biochemical, structural, or electrical abnormalities in the spinal cord, brain, or other nerves lead to different symptoms, including muscle weakness, paralysis, poor coordination, seizures, loss of sensation, and pain. There are many recognized neurological diseases, like epilepsy, Alzheimer's disease (AD), Parkinson's disease (PD), multiple sclerosis (MS), stroke, autosomal recessive cerebellar ataxia 2 (ARCA2), Leber's hereditary optic neuropathy (LHON), and spinocerebellar ataxia autosomal recessive 9 (SCAR9). Different agents, such as coenzyme Q10 (CoQ10), exert neuroprotective effects against neuronal damage. Online databases, such as Scopus, Google Scholar, Web of Science, and PubMed/MEDLINE were systematically searched until December 2020 using keywords, including review, neurological disorders, and CoQ10. CoQ10 is endogenously produced in the body and also can be found in supplements or foods. CoQ10 has antioxidant and anti-inflammatory effects and plays a role in energy production and mitochondria stabilization, which are mechanisms, by which CoQ10 exerts its neuroprotective effects. Thus, in this review, we discussed the association between CoQ10 and neurological diseases, including AD, depression, MS, epilepsy, PD, LHON, ARCA2, SCAR9, and stroke. In addition, new therapeutic targets were introduced for the next drug discoveries.

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“…Êàê ïîêàçàíî ðàíåå, CoQ10 ñïîñîáåí ïðîíèêàòü ÷åðåç ÃÝÁ [30,40,53]. È êðîìå òîãî, åñòü èññëåäîâàíèÿ, ïîäòâåðaeäàþùèå, ÷òî åãî ðàñïðåäåëåíèå â ðàçíûõ ñòðóêòóðàõ ìîçãà ðàçëè÷íî.…”

Section: êëåòêè íåéðîâàñêóëÿðíîé åäèíèöû ãîëîâíîãî ìîçãà êàê ïîòåíöèà...unclassified

Митохондрии клеток церебрального эндотелия как потенциальная мишень для нейропротекторного действия коэнзима Q<sub>10</sub>

Шаповал¹,

Медведев²,

Моргун³

et al. 2020

Эксп. и клин. фармакол.

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Клетки церебрального эндотелия выстилают сосуды головного мозга и образуют гематоэнцефалический барьер, отделяющий центральную нервную систему от циркулирующей крови. В настоящее время показано, что нарушение нормального функционирования клеток церебрального эндотелия способно приводить к различным патологиям, в том числе и к развитию нейродегенеративных заболеваний. Доказано, что коэнзим Q10 обладает нейропротекторным действием и является перспективным препаратом для лечения и профилактики ряда заболеваний, вызванных митохондриальными нарушениями. Изучение действия коэнзима Q10 на клетки церебрального эндотелия является важным и интересным направлением в нейрофармакологии, открывающим новые перспективы для решения вопроса управления проницаемостью ГЭБ, предотвращения развития нейровоспаления и нейродегенерации.

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Tissue-Level Dynamics and Redox State of Coenzyme Q10 in Rats After Intravenous Injection of Ubiquinol

Cited by 7 publications

References 17 publications

Intravenous Administration of Coenzyme Q10 in Acute Period of Cerebral Ischemia Decreases Mortality by Reducing Brain Necrosis and Limiting Its Increase within 4 Days in Rat Stroke Model

Intravenous Administration of Coenzyme Q10 in Acute Period of Cerebral Ischemia Decreases Mortality by Reducing Brain Necrosis and Limiting Its Increase within 4 Days in Rat Stroke Model

Neuroprotective effects of coenzyme Q10 on neurological diseases: a review article

Митохондрии клеток церебрального эндотелия как потенциальная мишень для нейропротекторного действия коэнзима Q<sub>10</sub>

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