Tissue iron quantification in chronic liver diseases using MRI shows a relationship between iron accumulation in liver, spleen, and bone marrow

França, Manuela; Martí‐Bonmatí, Luis; Porto, Graça; Silva, Sara; Guimarães, Susana; Vizcaíno, José R.; Miranda, Helena Pessegueiro

doi:10.1016/j.crad.2017.07.022

Cited by 26 publications

(25 citation statements)

References 28 publications

(30 reference statements)

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“…The distinction between the different iron distribution patterns is an important aspect in the differential diagnosis of iron overload disorders; therefore, R2* of the spleen and the pancreas should also be reported and, if possible, evaluated as pathological or not [52].…”

Section: How To Report?mentioning

confidence: 99%

Practical guide to quantification of hepatic iron with MRI

Henninger

Alústiza²,

Garbowski

et al. 2019

Eur Radiol

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Our intention is to demystify the MR quantification of hepatic iron (i.e., the liver iron concentration) and give you a step-by-step approach by answering the most pertinent questions. The following article should be more of a manual or guide for every radiologist than a classic review article, which just summarizes the literature. Furthermore, we provide important background information for professional communication with clinicians. The information regarding the physical background is reduced to a minimum. After reading this article, you should be able to perform adequate MR measurements of the LIC with 1.5-T or 3.0-T scanners.Key Points• MRI is widely accepted as the primary approach to non-invasively determine liver iron concentration (LIC).• This article is a guide for every radiologist to perform adequate MR measurements of the LIC.• When using R2* relaxometry, some points have to be considered to obtain correct measurements—all explained in this article.

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Section: How To Report?mentioning

confidence: 99%

Practical guide to quantification of hepatic iron with MRI

Henninger

Alústiza²,

Garbowski

et al. 2019

Eur Radiol

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show abstract

“…Iron is essential for many cellular and molecular process including cell growth, oxygen utilization, various enzymatic activities, and responses of immune systems, but excess iron load is harmful, leading to cellular dysfunction by catalyzing the formation of toxic free radicals (Zhuang, Han, & Yang, ). Abnormal iron accumulation could cause widespread organ damage including liver, heart, brain, renal, and bone (Franca et al, ). Case reports and clinical studies revealed that osteoporosis and bone fracture occur frequently in patients with diseases related to iron overload, such as hemoglobinopathies, hereditary hemochromatosis and sickle cell disease (Baldini et al, ; Valenti et al, ).…”

Section: Introductionmentioning

confidence: 99%

Icariin protects against iron overload‐induced bone loss via suppressing oxidative stress

Jing

Chen

et al. 2018

Journal Cellular Physiology

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Iron overload is common in patients with diseases such as hemoglobinopathies, hereditary hemochromatosis or elderly men and postmenopausal women. This disorder is frequently associated with bone loss and recently has been considered as an independent risk factor for osteoporosis. By excess reactive oxygen species (ROS) production through Fenton reaction, iron could induce osteoblast apoptosis, inhibit osteoblast osteogenic differentiation. Moreover, Iron could also promote osteoclasts differentiation and bone absorption. The goal of the study is to investigate whether icariin could reverse iron overload‐induced bone loss in vitro and in vivo. Icariin is the major active ingredient of Herba Epimedii and has antioxidant, antiosteoporosis functions. In the current study, we demonstrated that oral administration of icariin significantly prevented bone loss in iron overloaded mice. Icariin could protect against iron overload‐induced mitochondrial membrane potential dysfunction and ROS production, promote osteoblast survival and reverse the reduction of Runx2, alkaline phosphatase, and osteopontin expression induced by iron overload. Icariin also inhibited osteoclasts differentiation and function. Moreover, we also found that icariin remarkably reduced iron accumulation in bone marrow, suggesting that icariin has the ability to regulate systemic iron metabolism in vivo. These results indicated that icariin could be a potential natural resource for developing medicines to prevent or treat iron overload‐induced osteoporosis.

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“…We have recently implemented a 3 Tesla multi‐echo chemical shift‐encoded gradient‐echo magnetic resonance (MECSE‐MR) sequence, with high accuracy to simultaneously quantify liver steatosis, assessed as proton density fat fraction (PDFF), and iron overload, assessed by R2* measurements (Martí‐Bonmatí et al , ; França et al , ,b). The same images also allow evaluation of the distribution of iron deposits in different abdominal tissues (França et al , b). This method might be useful for predicting mobilizable total body iron stores (TBIS) during IPh and for assessing liver iron re‐accumulation in MPh.…”

Section: Regression Results Regression Results Showing Different Tesmentioning

confidence: 99%

Optimizing the management of hereditary haemochromatosis: the value of MRI R2* quantification to predict and monitor body iron stores

et al. 2017

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Tissue iron quantification in chronic liver diseases using MRI shows a relationship between iron accumulation in liver, spleen, and bone marrow

Cited by 26 publications

References 28 publications

Practical guide to quantification of hepatic iron with MRI

Practical guide to quantification of hepatic iron with MRI

Icariin protects against iron overload‐induced bone loss via suppressing oxidative stress

Optimizing the management of hereditary haemochromatosis: the value of MRI R2* quantification to predict and monitor body iron stores

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