Tissue inhibitor of metalloproteinases from human bone marrow stromal cell line KM 102 has erythroid‐potentiating activity, suggesting its possibly bifunctional role in the hematopoietic microenvironment

Hayakawa, Taro; Yamashita, Kyoko; Kishi, Jun-Ichi; Harigaya, Kenichi

doi:10.1016/0014-5793(90)80989-v

Cited by 48 publications

(25 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…4 To what extent the pleiotropic effects of TIMP-1 produced in the hematopoietic microenvironment influence normal hematopoiesis and/or the development of hematological malignancies remains unknown. Our results attempt to evidence that TIMP-1, as a BM microenvironment constituent, is involved in the erythroid cell physiology.…”

Section: Discussionmentioning

confidence: 99%

“…2 Besides their MMPs inhibitory activity, TIMPs and in particular TIMP-1 exhibit other biological functions in cell survival, differentiation and proliferation. 3 TIMP-1 has first been described for its erythroid potentiating activity and then proposed as an important regulator of erythropoiesis 4 able to stimulate the proliferation of K562 leukemia cells 5 and both early and late erythroid committed stem cells from human bone marrow (BM). 6 However, Hayakawa et al 7 have demonstrated that TIMP-1 also exhibited mitogenic activity in other cells and proposed TIMP-1 as a new cell-growth factor.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Tissue inhibitor of metalloproteinase-1 promotes hematopoietic differentiation via caspase-3 upstream the MEKK1/MEK6/p38α pathway

Dassé

Bridoux

Baranek³

et al. 2007

Leukemia

View full text Add to dashboard Cite

Besides its matrix metalloproteinases inhibitory activity, TIMP-1 exhibits other biological activities such as cell survival and proliferation. The intracellular signalling pathway elicited by TIMP-1 begins to be elucidated. We have shown previously that the caspase-3 and the p38a MAP kinase were activated during TIMP-1-induced UT-7 cells erythroid differentiation. In this study, we demonstrated that TIMP-1 differentiating effect can be extended to the IL-3-dependent myeloid murine 32D cell line and human erythroid progenitors derived from cord blood CD34 þ cells. By performing small interfering RNA transfection and using chemical inhibitors, we evidenced that caspase-3 was involved in TIMP-1 differentiating effect. We then identified the MEKK1 kinase as a caspase-3 substrate and demonstrated that the MEKK1/MEK6/p38a pathway was activated downstream the caspase-3 in TIMP-1-induced hematopoietic differentiation.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Tissue inhibitor of metalloproteinase-1 promotes hematopoietic differentiation via caspase-3 upstream the MEKK1/MEK6/p38α pathway

Dassé

Bridoux

Baranek³

et al. 2007

Leukemia

View full text Add to dashboard Cite

show abstract

“…TIMPs are believed to play a role in such diverse phenomena as erythropoiesis (Gasson et al, 1985;Hayakawa et al, 1990;Stetler-Stevenson et al, 1992b), bone resorption (Hill et al, 19931, ovulation (Curry et al, 19901, placentation (Lala and Graham, 1990;Graham and Lala, 19911, mammary gland involution (Talhouk et al, 1992), arthritic destruction of cartilage (Pelletier et al, 1990;Dean et al, 1989b) and the local and systemic spread of malignant tumors (Liotta and Stetler-Stevenson, 1990). High levels of TIMP-1 in the corpus luteum of pregnancy may play a role in the maintenance of pregnancy (Nomura et al, 1989).…”

Section: Introductionmentioning

confidence: 99%

Gene encoding a novel murine tissue inhibitor of metalloproteinases (TIMP), TIMP‐3, is expressed in developing mouse epithelia, cartilage, and muscle, and is located on mouse chromosome 10

Apte

Hayashi

Seldin

et al. 1994

Developmental Dynamics

129

View full text Add to dashboard Cite

Remodeling of the extracellular matrix (ECM) is an essential component of normal development and is also involved in the pathogenesis of arthritis and the spread of cancer. The matrix metalloproteinases and their natural inhibitors, the tissue inhibitors of metalloproteinases (TIMPs), play an important role in this context. We have isolated mouse cDNA clones encoding a novel member of the TIMP family, designated TIMP-3. We have assigned the Timp-3 locus to the [Cl-D11 region of mouse chromosome 10 using both genetic and cytogenetic methods. The conceptual translation product of the Timp-3 cDNA shows a high degree of similarity with ChIMP-3, a recently cloned chicken metalloproteinase inhibitor, as well as significant structural similarity with the amino acid sequences of the previously isolated members of this family, TIMP-1 and TIMP-2. The pattern of expression of Timp-3 in the developing mouse embryo is distinct from that previously reported for Timp-1. Timp-3 is expressed in cartilage and skeletal muscle, in myocardium, in the skin, oral and nasal epithelium, in the newborn mouse liver, in the epithelium of some tubular structures such as the developing bronchial tree, oesophagus, colon, urogenital sinus, bile duct, in the kidney, salivary glands, and in the choroid plexus of the brain. The patterns of Timp-3 expression in surface epithelia and in the epithelial lining of many tubular organs suggests that TIMP-3 may be involved in regulating ECM remodeling during the folding of epithelia and during the formation, branching, and expansion of epithelial tubes. In the mouse placenta, expression is seen in the trophoblast, raising the possibility that TIMP-3 may be involved in regulating trophoblastic invasion of the uterus. We propose a role for TIMP-3 in musculoskeletal and cardiac development, in the morphogenesis of certain epithelial structures, and placental implantation.

show abstract

“…However, in addition to blocking MMP activity, TIMPs have also been shown to exert growth factor activities that are independent of their enzymatic inhibitory function. [4][5][6][7][8][9][10] We have previously reported on the high-level expression of TIMP-1 by normal activated tonsillar B cells and centroblast-like Burkitt lymphoma cell lines. 11 TIMP-1 expression is operative at a specific stage in B-cell development and is associated with the germinal center phenotype that occurs with the generation of lymphoblasts.…”

Section: Introductionmentioning

confidence: 99%

Tissue inhibitor of metalloproteinases 1 regulation of interleukin-10 in B-cell differentiation and lymphomagenesis

Guédez

Mansoor

Birkedal-Hansen

et al. 2001

Blood

View full text Add to dashboard Cite

Tissue inhibitor of metalloproteinases from human bone marrow stromal cell line KM 102 has erythroid‐potentiating activity, suggesting its possibly bifunctional role in the hematopoietic microenvironment

Cited by 48 publications

References 38 publications

Tissue inhibitor of metalloproteinase-1 promotes hematopoietic differentiation via caspase-3 upstream the MEKK1/MEK6/p38α pathway

Tissue inhibitor of metalloproteinase-1 promotes hematopoietic differentiation via caspase-3 upstream the MEKK1/MEK6/p38α pathway

Gene encoding a novel murine tissue inhibitor of metalloproteinases (TIMP), TIMP‐3, is expressed in developing mouse epithelia, cartilage, and muscle, and is located on mouse chromosome 10

Tissue inhibitor of metalloproteinases 1 regulation of interleukin-10 in B-cell differentiation and lymphomagenesis

Contact Info

Product

Resources

About