Tissue inhibitor of metalloprotease-1 (TIMP-1) serum level may predict progression of hip osteoarthritis

Chevalier, Xavier; Conrozier, T; Gehrmann, Mathias; Claudepierre, Pascal; Mathieu, Pierre; Unger, Sigrun; Vignon, E.

doi:10.1053/joca.2000.0389

Cited by 40 publications

(27 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The strong induction of both MMPs and TIMP-1 suggests a role in tissue remodeling. Increased expression of both MMPs and TIMP-1 have been observed in human OA (40,41).…”

Section: Discussionmentioning

confidence: 98%

Basic FGF mediates an immediate response of articular cartilage to mechanical injury

Vincent¹,

Hermansson²,

Bolton³

et al. 2002

Proc. Natl. Acad. Sci. U.S.A.

205

228

View full text Add to dashboard Cite

The extracellularly regulated kinase (ERK), one of the three types of mitogen-activated kinases, was rapidly activated after cutting porcine articular cartilage either when maintained as explants or in situ. Cutting released a soluble ERK-activating factor from the cartilage, which was purified and identified by MS as basic fibroblast growth factor (bFGF). Experiments with neutralizing Abs to bFGF and an FGFR1 tyrosine kinase inhibitor showed that this growth factor was the major ERK-activating factor released after injury. Treating cartilage with the heparin-degrading enzyme heparitinase also caused release of bFGF, suggesting the presence of an extracellular store that is sequestered in the matrix and released upon damage. Basic FGF induced the synthesis of a number of chondrocyte proteins including matrix metalloproteinases 1 and 3, tissue inhibitor of metalloproteinases-1, and glycoprotein 38, which were identified by MS. The strong induction of matrix metalloproteinases and tissue inhibitor of metalloproteinases-1 suggests that bFGF could have a role in remodeling damaged tissue.

show abstract

“…The strong induction of both MMPs and TIMP-1 suggests a role in tissue remodeling. Increased expression of both MMPs and TIMP-1 have been observed in human OA (40,41).…”

Section: Discussionmentioning

confidence: 98%

Basic FGF mediates an immediate response of articular cartilage to mechanical injury

Vincent¹,

Hermansson²,

Bolton³

et al. 2002

Proc. Natl. Acad. Sci. U.S.A.

205

228

View full text Add to dashboard Cite

show abstract

“…Eleven ''progression'' studies [7-9, 15, 17, 24, 29, 30, 35, 37, 39] investigated the association of 13 different biomarker levels with the progression of hip OA. Of the 11 studies, four looked at progression of known hip OA [9,15,37,39]; three studies investigated the progression to incident hip OA from unspecified prearthritic hip disease [8,17,29]; and four studies investigated both OA progression and incidence [7,24,30,35]. Duration of followup to evaluate OA progression ranged from 1 year to 15 years.…”

Section: Literature Searchmentioning

confidence: 99%

What Is the Utility of Biomarkers for Assessing the Pathophysiology of Hip Osteoarthritis? A Systematic Review

Nepple

Thomason

et al. 2015

Clinical Orthopaedics &Amp; Related Research

View full text Add to dashboard Cite

show abstract

“…Despite numerous attempts to elucidate pathogenetic factors, the origin and the complex nature of rapidly destructive hip OA still remain unclear [3,7]. Radiographic findings in this disease can mimic those of other disorders, such as septic arthritis, rheumatoid and seronegative arthritis and primary osteonecrosis with secondary OA [21].…”

Section: Discussionmentioning

confidence: 99%

“…Accordingly, urinary levels of type II collagen C-telopeptide (CTX-II) have been reported to be significantly higher in patients with rapidly destructive hip OA than in patients with slowly progressive hip OA [8]. Increased levels of matrix metalloproteinases (MMP-3 and -9) and decreased levels of tissue inhibitor of matrix metalloproteinases (TIMP) in serum and joint fluid have pointed to a basic involvement of MMP in the pathogenesis of rapidly destructive hip OA [3,12,16]. Serum levels of C-terminal cross-linking telopeptide of collagen type I (ICTP) have been shown to reflect degradation of collagen type I in various bone pathologies, including rheumatoid arthritis [10], neuroosteoarthropathy of the foot [18] and aseptic loosening after total hip arthroplasty (THA) [24].…”

Section: Introductionmentioning

confidence: 99%

Elevated levels of serum type I collagen C-telopeptide in patients with rapidly destructive osteoarthritis of the hip

Berger

Kröner

Stiegler

et al. 2004

International Orthopaedics (SICOT)

View full text Add to dashboard Cite

We compared type I collagen degradation using serum cross-linking C-terminal telopeptide (ICTP) in 18 patients with rapidly destructive osteoarthrosis and in 20 patients with slowly progressive osteoarthrosis of the hip. The diagnosis was established by clinical examination and radiographic evaluation. Total hip arthroplasty was performed in all patients. Serum levels of ICTP, bone-specific alkaline phosphatase, osteocalcin and N-terminal propeptide were studied. Patients with rapidly destructive osteoarthrosis had higher mean (SD) serum ICTP levels than patients with slowly progressive osteoarthrosis [13.2 (5.6) versus 3.7 ng/ml (1.4), p=0.001] whereas no significant difference of all other markers was seen between the groups. Elevation of ICTP levels correlated significantly with decreased joint-space width assessed by radiographs of the hip (p=0.01). Our data suggest that rapidly destructive hip osteoarthrosis is associated with elevated serum ICTP levels, reflecting increased collagen type I degradation.Résumé Nous avons comparé la dégradation du collagène type I en utilisant le cross-linking du telopeptide Terminal C (ICTP) chez 18 malades avearthrose rapidement destructrice et chez 20 malades avecarthrose lentement progressive de la hanche. Le diagnostic a été établi par examen clinique et évaluation radiographique. L'arthroplastie totale de la hanche a été exécuté chez tous les malades. Le niveau sérique d'ICTP, des phosphatases alcalines osseuse spécifiques, de l'ostéocalcine, et du propeptide N-Terminal a été étudié. Les malades avec arthrose rapidement destructrice avaient une moyenne du niveau d'ICTP nettement plus haute que les malades avec arthrose lentement progressive [13.2 (5.6) vs 3.7 ng/ml (1.4), p=0.001], alors qu'aucune différence notable de tous les autres marqueurs n'a été notée entre les groupes. L'élévation de niveau de l› ICTP était en corrélation avec la hauteur de l'interligne articulaire apprécié par des radiographies (p=0.01). Nos données suggèrent que l'arthrose rapidement destructive est associé à une élévation sérique de l'ICTP reflétant une augmentation de la dé-gradation du collagène de type I.

show abstract

Tissue inhibitor of metalloprotease-1 (TIMP-1) serum level may predict progression of hip osteoarthritis

Abstract: TIMP-1 serum level may serve to predict the evolution of patients with hip OA.

Cited by 40 publications

References 32 publications

Basic FGF mediates an immediate response of articular cartilage to mechanical injury

Basic FGF mediates an immediate response of articular cartilage to mechanical injury

What Is the Utility of Biomarkers for Assessing the Pathophysiology of Hip Osteoarthritis? A Systematic Review

Elevated levels of serum type I collagen C-telopeptide in patients with rapidly destructive osteoarthritis of the hip

Contact Info

Product

Resources

About